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Article: Prediction of response to cardiac resynchronization therapy combining two different three-dimensional analyses of left ventricular dyssynchrony

TitlePrediction of response to cardiac resynchronization therapy combining two different three-dimensional analyses of left ventricular dyssynchrony
Authors
Issue Date2011
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
The American Journal of Cardiology, 2011, v. 108 n. 5, p. 711-717 How to Cite?
AbstractTriplane tissue synchronization imaging (TSI) and real-time 3-dimensional echocardiography (RT3DE) provide different characterizations of left ventricular (LV) mechanics and dyssynchrony. Triplane TSI assesses differences in time to peak systolic segmental myocardial tissue velocities, whereas RT3DE evaluates differences in time to minimum end-systolic regional volumes. Whether an approach using the 2 3D techniques predicts better significant reverse remodeling after cardiac resynchronization therapy (CRT) remains unknown. In 166 patients (mean age 66 +/- 9 years, 78% men) treated with CRT, baseline LV dyssynchrony was assessed using RT3DE and triplane TSI. LV dyssynchrony was defined by a systolic dyssynchrony index >/=6.4% when assessed with RT3DE and SD of time to peak velocity of 12 segments (Ts-SD-12) >/=33 ms with triplane TSI. CRT response was defined by >/=15% decrease in LV end-systolic volume at 6-month follow-up. Mean LV dyssynchrony using Ts-SD-12 was 48 +/- 26 ms and mean systolic dyssynchrony index was 8.51 +/- 3.81%. Response to CRT was observed in 86.3% of patients showing LV dyssynchrony with the 2 methods. In contrast, 97% of patients who did not show significant LV dyssynchrony with any of the techniques were nonresponders (p <0.001). Importantly, systolic dyssynchrony index and LV dyssynchrony using Ts-SD-12 were independent predictors of response to CRT (p <0.001 for each technique). Assessment of LV dyssynchrony with the 2 techniques showed incremental value for prediction of significant LV reverse remodeling over its assessment with only 1 technique (chi-square 90.18, p <0.001). In conclusion, the combined use of 2 different 3D techniques to assess LV dyssynchrony permits accurate prediction of response to CRT.
Persistent Identifierhttp://hdl.handle.net/10722/163391
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAuger, Den_US
dc.contributor.authorBertini, Men_US
dc.contributor.authorMarsan, NAen_US
dc.contributor.authorHoke, Uen_US
dc.contributor.authorEwe, SHen_US
dc.contributor.authorThijssen, Jen_US
dc.contributor.authorWitkowski, TGen_US
dc.contributor.authorYiu, KHen_US
dc.contributor.authorNG, ACTen_US
dc.contributor.authorvan de Wall, EEen_US
dc.contributor.authorSchalij, MJen_US
dc.contributor.authorBax, JJen_US
dc.contributor.authorDelgado, Ven_US
dc.date.accessioned2012-09-05T05:30:51Z-
dc.date.available2012-09-05T05:30:51Z-
dc.date.issued2011en_US
dc.identifier.citationThe American Journal of Cardiology, 2011, v. 108 n. 5, p. 711-717en_US
dc.identifier.issn0002-9149en_US
dc.identifier.urihttp://hdl.handle.net/10722/163391-
dc.description.abstractTriplane tissue synchronization imaging (TSI) and real-time 3-dimensional echocardiography (RT3DE) provide different characterizations of left ventricular (LV) mechanics and dyssynchrony. Triplane TSI assesses differences in time to peak systolic segmental myocardial tissue velocities, whereas RT3DE evaluates differences in time to minimum end-systolic regional volumes. Whether an approach using the 2 3D techniques predicts better significant reverse remodeling after cardiac resynchronization therapy (CRT) remains unknown. In 166 patients (mean age 66 +/- 9 years, 78% men) treated with CRT, baseline LV dyssynchrony was assessed using RT3DE and triplane TSI. LV dyssynchrony was defined by a systolic dyssynchrony index >/=6.4% when assessed with RT3DE and SD of time to peak velocity of 12 segments (Ts-SD-12) >/=33 ms with triplane TSI. CRT response was defined by >/=15% decrease in LV end-systolic volume at 6-month follow-up. Mean LV dyssynchrony using Ts-SD-12 was 48 +/- 26 ms and mean systolic dyssynchrony index was 8.51 +/- 3.81%. Response to CRT was observed in 86.3% of patients showing LV dyssynchrony with the 2 methods. In contrast, 97% of patients who did not show significant LV dyssynchrony with any of the techniques were nonresponders (p <0.001). Importantly, systolic dyssynchrony index and LV dyssynchrony using Ts-SD-12 were independent predictors of response to CRT (p <0.001 for each technique). Assessment of LV dyssynchrony with the 2 techniques showed incremental value for prediction of significant LV reverse remodeling over its assessment with only 1 technique (chi-square 90.18, p <0.001). In conclusion, the combined use of 2 different 3D techniques to assess LV dyssynchrony permits accurate prediction of response to CRT.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_US
dc.relation.ispartofThe American Journal of Cardiologyen_US
dc.subject.meshCardiac Resynchronization Therapyen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshEchocardiography, Three-Dimensional - methodsen_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshVentricular Dysfunction, Left - physiopathology - therapy - ultrasonographyen_US
dc.titlePrediction of response to cardiac resynchronization therapy combining two different three-dimensional analyses of left ventricular dyssynchronyen_US
dc.typeArticleen_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.authorityYiu, KH=rp01490en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.amjcard.2011.04.023en_US
dc.identifier.pmid21714949-
dc.identifier.scopuseid_2-s2.0-80051808637en_US
dc.identifier.hkuros205926-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051808637&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume108en_US
dc.identifier.issue5en_US
dc.identifier.spage711en_US
dc.identifier.epage717en_US
dc.identifier.isiWOS:000294751000017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDelgado, V=24172709900en_US
dc.identifier.scopusauthoridBax, JJ=35379683700en_US
dc.identifier.scopusauthoridSchalij, MJ=7007083597en_US
dc.identifier.scopusauthoridVan Der Wall, EE=7101764510en_US
dc.identifier.scopusauthoridNg, ACT=15726084000en_US
dc.identifier.scopusauthoridYiu, KH=35172267800en_US
dc.identifier.scopusauthoridWitkowski, TG=7003737196en_US
dc.identifier.scopusauthoridThijssen, J=36461837900en_US
dc.identifier.scopusauthoridEwe, SH=23993827400en_US
dc.identifier.scopusauthoridHoke, U=49663102100en_US
dc.identifier.scopusauthoridMarsan, NA=23035780700en_US
dc.identifier.scopusauthoridBertini, M=22033600300en_US
dc.identifier.scopusauthoridAuger, D=35723808000en_US
dc.identifier.citeulike9486328-

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