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Article: Effect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation

TitleEffect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation
Authors
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 2011, v. 58 n. 1, p. 87-90 How to Cite?
AbstractIt has been established that herbal intake affects the anticoagulation effects of warfarin, but the long-term impact on anticoagulation control is unclear. We sought to investigate the effect of concomitant herbal intake on anticoagulation control in patients with nonvalvular atrial fibrillation (AF) treated with warfarin. The effects of common herbs were determined by monitoring the international normalized ratio in 250 patients with AF (69 ± 10 years, 50% male). All the patients had been prescribed warfarin therapy for at least 6 months before enrollment, and their dietary intake, including the type and the frequency of common herbs, was recorded using a standardized questionnaire. Up to 50% of the patients reported consumption of foods with herbal ingredients, including garlic (80.4%), ginger (74.8%), green tea (50.4%), and papaya (55.2%) but rarely herbal drugs such as danshen (1.2%), dong guai (0.8%), fenugreek (1.2%), psyllium seed (0.4%), and ginseng (4%). Infrequent users (1 kind of herb for <4 times per week and nonusers) were more likely to have an international normalized ratio within the optimal therapeutic range (2.0-3.0) than frequent users (>1 kind of herb for ↰¥ 4 times per week) (58.1% vs 51.1%, P = 0.046). In conclusion, the patients with AF treated with warfarin had little knowledge about the potential interaction of herbal substances in foods with warfarin. The patients who consumed common herbs at least 4 times per week had suboptimal anticoagulation control with warfarin. © 2011 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/163387
ISSN
2014 Impact Factor: 2.135
2014 SCImago Journal Rankings: 0.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, HTen_US
dc.contributor.authorSo, LTen_US
dc.contributor.authorLi, SWen_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2012-09-05T05:30:48Z-
dc.date.available2012-09-05T05:30:48Z-
dc.date.issued2011en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 2011, v. 58 n. 1, p. 87-90en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/163387-
dc.description.abstractIt has been established that herbal intake affects the anticoagulation effects of warfarin, but the long-term impact on anticoagulation control is unclear. We sought to investigate the effect of concomitant herbal intake on anticoagulation control in patients with nonvalvular atrial fibrillation (AF) treated with warfarin. The effects of common herbs were determined by monitoring the international normalized ratio in 250 patients with AF (69 ± 10 years, 50% male). All the patients had been prescribed warfarin therapy for at least 6 months before enrollment, and their dietary intake, including the type and the frequency of common herbs, was recorded using a standardized questionnaire. Up to 50% of the patients reported consumption of foods with herbal ingredients, including garlic (80.4%), ginger (74.8%), green tea (50.4%), and papaya (55.2%) but rarely herbal drugs such as danshen (1.2%), dong guai (0.8%), fenugreek (1.2%), psyllium seed (0.4%), and ginseng (4%). Infrequent users (1 kind of herb for <4 times per week and nonusers) were more likely to have an international normalized ratio within the optimal therapeutic range (2.0-3.0) than frequent users (>1 kind of herb for ↰¥ 4 times per week) (58.1% vs 51.1%, P = 0.046). In conclusion, the patients with AF treated with warfarin had little knowledge about the potential interaction of herbal substances in foods with warfarin. The patients who consumed common herbs at least 4 times per week had suboptimal anticoagulation control with warfarin. © 2011 by Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAtrial Fibrillation - Blood - Drug Therapyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHerb-Drug Interactions - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInternational Normalized Ratio - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPlant Preparations - Blood - Therapeutic Useen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWarfarin - Blood - Therapeutic Useen_US
dc.titleEffect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillationen_US
dc.typeArticleen_US
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/FJC.0b013e31821cd888en_US
dc.identifier.pmid21558883en_US
dc.identifier.scopuseid_2-s2.0-79960415771en_US
dc.identifier.hkuros187309-
dc.identifier.hkuros208719-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960415771&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume58en_US
dc.identifier.issue1en_US
dc.identifier.spage87en_US
dc.identifier.epage90en_US
dc.identifier.isiWOS:000292682000013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, HT=22633582100en_US
dc.identifier.scopusauthoridSo, LT=46062374700en_US
dc.identifier.scopusauthoridLi, SW=13807028100en_US
dc.identifier.scopusauthoridSiu, CW=7006550690en_US
dc.identifier.scopusauthoridLau, CP=7401968501en_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US

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