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Article: Effect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation
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TitleEffect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation
 
AuthorsChan, HT2
So, LT2
Li, SW3
Siu, CW2
Lau, CP2
Tse, HF2 1
 
Issue Date2011
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
 
CitationJournal Of Cardiovascular Pharmacology, 2011, v. 58 n. 1, p. 87-90 [How to Cite?]
DOI: http://dx.doi.org/10.1097/FJC.0b013e31821cd888
 
AbstractIt has been established that herbal intake affects the anticoagulation effects of warfarin, but the long-term impact on anticoagulation control is unclear. We sought to investigate the effect of concomitant herbal intake on anticoagulation control in patients with nonvalvular atrial fibrillation (AF) treated with warfarin. The effects of common herbs were determined by monitoring the international normalized ratio in 250 patients with AF (69 ± 10 years, 50% male). All the patients had been prescribed warfarin therapy for at least 6 months before enrollment, and their dietary intake, including the type and the frequency of common herbs, was recorded using a standardized questionnaire. Up to 50% of the patients reported consumption of foods with herbal ingredients, including garlic (80.4%), ginger (74.8%), green tea (50.4%), and papaya (55.2%) but rarely herbal drugs such as danshen (1.2%), dong guai (0.8%), fenugreek (1.2%), psyllium seed (0.4%), and ginseng (4%). Infrequent users (1 kind of herb for <4 times per week and nonusers) were more likely to have an international normalized ratio within the optimal therapeutic range (2.0-3.0) than frequent users (>1 kind of herb for ↰¥ 4 times per week) (58.1% vs 51.1%, P = 0.046). In conclusion, the patients with AF treated with warfarin had little knowledge about the potential interaction of herbal substances in foods with warfarin. The patients who consumed common herbs at least 4 times per week had suboptimal anticoagulation control with warfarin. © 2011 by Lippincott Williams & Wilkins.
 
ISSN0160-2446
2013 Impact Factor: 2.111
 
DOIhttp://dx.doi.org/10.1097/FJC.0b013e31821cd888
 
ISI Accession Number IDWOS:000292682000013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, HT
 
dc.contributor.authorSo, LT
 
dc.contributor.authorLi, SW
 
dc.contributor.authorSiu, CW
 
dc.contributor.authorLau, CP
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2012-09-05T05:30:48Z
 
dc.date.available2012-09-05T05:30:48Z
 
dc.date.issued2011
 
dc.description.abstractIt has been established that herbal intake affects the anticoagulation effects of warfarin, but the long-term impact on anticoagulation control is unclear. We sought to investigate the effect of concomitant herbal intake on anticoagulation control in patients with nonvalvular atrial fibrillation (AF) treated with warfarin. The effects of common herbs were determined by monitoring the international normalized ratio in 250 patients with AF (69 ± 10 years, 50% male). All the patients had been prescribed warfarin therapy for at least 6 months before enrollment, and their dietary intake, including the type and the frequency of common herbs, was recorded using a standardized questionnaire. Up to 50% of the patients reported consumption of foods with herbal ingredients, including garlic (80.4%), ginger (74.8%), green tea (50.4%), and papaya (55.2%) but rarely herbal drugs such as danshen (1.2%), dong guai (0.8%), fenugreek (1.2%), psyllium seed (0.4%), and ginseng (4%). Infrequent users (1 kind of herb for <4 times per week and nonusers) were more likely to have an international normalized ratio within the optimal therapeutic range (2.0-3.0) than frequent users (>1 kind of herb for ↰¥ 4 times per week) (58.1% vs 51.1%, P = 0.046). In conclusion, the patients with AF treated with warfarin had little knowledge about the potential interaction of herbal substances in foods with warfarin. The patients who consumed common herbs at least 4 times per week had suboptimal anticoagulation control with warfarin. © 2011 by Lippincott Williams & Wilkins.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 2011, v. 58 n. 1, p. 87-90 [How to Cite?]
DOI: http://dx.doi.org/10.1097/FJC.0b013e31821cd888
 
dc.identifier.doihttp://dx.doi.org/10.1097/FJC.0b013e31821cd888
 
dc.identifier.epage90
 
dc.identifier.hkuros187309
 
dc.identifier.hkuros208719
 
dc.identifier.isiWOS:000292682000013
 
dc.identifier.issn0160-2446
2013 Impact Factor: 2.111
 
dc.identifier.issue1
 
dc.identifier.pmid21558883
 
dc.identifier.scopuseid_2-s2.0-79960415771
 
dc.identifier.spage87
 
dc.identifier.urihttp://hdl.handle.net/10722/163387
 
dc.identifier.volume58
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Cardiovascular Pharmacology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshAtrial Fibrillation - Blood - Drug Therapy
 
dc.subject.meshCohort Studies
 
dc.subject.meshFollow-Up Studies
 
dc.subject.meshHerb-Drug Interactions - Physiology
 
dc.subject.meshHumans
 
dc.subject.meshInternational Normalized Ratio - Methods
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPlant Preparations - Blood - Therapeutic Use
 
dc.subject.meshQuestionnaires
 
dc.subject.meshTime Factors
 
dc.subject.meshWarfarin - Blood - Therapeutic Use
 
dc.titleEffect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation
 
dc.typeArticle
 
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<contributor.author>Tse, HF</contributor.author>
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<description.abstract>It has been established that herbal intake affects the anticoagulation effects of warfarin, but the long-term impact on anticoagulation control is unclear. We sought to investigate the effect of concomitant herbal intake on anticoagulation control in patients with nonvalvular atrial fibrillation (AF) treated with warfarin. The effects of common herbs were determined by monitoring the international normalized ratio in 250 patients with AF (69 &#177; 10 years, 50% male). All the patients had been prescribed warfarin therapy for at least 6 months before enrollment, and their dietary intake, including the type and the frequency of common herbs, was recorded using a standardized questionnaire. Up to 50% of the patients reported consumption of foods with herbal ingredients, including garlic (80.4%), ginger (74.8%), green tea (50.4%), and papaya (55.2%) but rarely herbal drugs such as danshen (1.2%), dong guai (0.8%), fenugreek (1.2%), psyllium seed (0.4%), and ginseng (4%). Infrequent users (1 kind of herb for &lt;4 times per week and nonusers) were more likely to have an international normalized ratio within the optimal therapeutic range (2.0-3.0) than frequent users (&gt;1 kind of herb for &#195;&#162;&#226;&#8364; &#176;&#194;&#165; 4 times per week) (58.1% vs 51.1%, P = 0.046). In conclusion, the patients with AF treated with warfarin had little knowledge about the potential interaction of herbal substances in foods with warfarin. The patients who consumed common herbs at least 4 times per week had suboptimal anticoagulation control with warfarin. &#169; 2011 by Lippincott Williams &amp; Wilkins.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Tung Wah Hospital