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Article: Evaluation of performance of measurement of faecal α 1- antitrypsin clearance and technetium-99m human serum albumin scintigraphy in protein-losing enteropathy

TitleEvaluation of performance of measurement of faecal α 1- antitrypsin clearance and technetium-99m human serum albumin scintigraphy in protein-losing enteropathy
Authors
Issue Date2011
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 2011, v. 84 n. 3, p. 199-206 How to Cite?
AbstractBackground and Aim: Our study aimed to compare the performance of faecal α 1-antitrypsin clearance (AATC) and radiolabelled human serum albumin (HSA) scintigraphy in protein-losing enteropathy (PLE). Methods: Patients studied by both AATC and technetium-99m ( 99mTc)-labelled HSA scintigraphy were recruited and categorized into PLE and non-PLE groups based on clinical and laboratory findings. The performance of AATC and 99mTc-labelled HSA scintigraphy was evaluated using clinical diagnosis of PLE as a gold standard. Results: 29 patients were recruited and 13 patients were considered to have definite PLE (PLE group). In the PLE group, all patients had a positive HSA scinigraphy and 10 (77%) had demonstrable positive tracing in the early phase. Conversely, only 6 of them (46%) had elevated AATC level (>13 m/day). Results of 99mTc-labelled HSA scan (but not AATC) showed significant agreement with the clinical diagnosis (κ 0.35, p = 0.013). 99mTc-labelled HSA scintigraphy carried higher sensitivity (100 vs. 46%) and negative predictive value (100 vs. 63%) compared to AATC in diagnosing PLE. The correlation between the results of these two investigations was only modest (κ 0.27, p = 0.04). The area under the receiver operating characteristic curve of AATC level showed no optimal diagnostic cut-off for PLE. Conclusion: 99mTc-labelled HSA scintigraphy was superior to AATC in diagnosing PLE. © 2011 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/163386
ISSN
2015 Impact Factor: 1.884
2015 SCImago Journal Rankings: 0.953
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChau, TNen_US
dc.contributor.authorMok, MYen_US
dc.contributor.authorChan, EYTen_US
dc.contributor.authorLuk, WHen_US
dc.contributor.authorLai, KBen_US
dc.contributor.authorLi, FTWen_US
dc.contributor.authorLeung, VKSen_US
dc.contributor.authorWong, Ren_US
dc.date.accessioned2012-09-05T05:30:48Z-
dc.date.available2012-09-05T05:30:48Z-
dc.date.issued2011en_US
dc.identifier.citationDigestion, 2011, v. 84 n. 3, p. 199-206en_US
dc.identifier.issn0012-2823en_US
dc.identifier.urihttp://hdl.handle.net/10722/163386-
dc.description.abstractBackground and Aim: Our study aimed to compare the performance of faecal α 1-antitrypsin clearance (AATC) and radiolabelled human serum albumin (HSA) scintigraphy in protein-losing enteropathy (PLE). Methods: Patients studied by both AATC and technetium-99m ( 99mTc)-labelled HSA scintigraphy were recruited and categorized into PLE and non-PLE groups based on clinical and laboratory findings. The performance of AATC and 99mTc-labelled HSA scintigraphy was evaluated using clinical diagnosis of PLE as a gold standard. Results: 29 patients were recruited and 13 patients were considered to have definite PLE (PLE group). In the PLE group, all patients had a positive HSA scinigraphy and 10 (77%) had demonstrable positive tracing in the early phase. Conversely, only 6 of them (46%) had elevated AATC level (>13 m/day). Results of 99mTc-labelled HSA scan (but not AATC) showed significant agreement with the clinical diagnosis (κ 0.35, p = 0.013). 99mTc-labelled HSA scintigraphy carried higher sensitivity (100 vs. 46%) and negative predictive value (100 vs. 63%) compared to AATC in diagnosing PLE. The correlation between the results of these two investigations was only modest (κ 0.27, p = 0.04). The area under the receiver operating characteristic curve of AATC level showed no optimal diagnostic cut-off for PLE. Conclusion: 99mTc-labelled HSA scintigraphy was superior to AATC in diagnosing PLE. © 2011 S. Karger AG, Basel.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIGen_US
dc.relation.ispartofDigestionen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChilden_US
dc.subject.meshFeces - Chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOrganotechnetium Compounds - Diagnostic Useen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshProtein-Losing Enteropathies - Etiology - Metabolism - Radionuclide Imagingen_US
dc.subject.meshRoc Curveen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSerum Albumin - Diagnostic Use - Metabolismen_US
dc.subject.meshYoung Adulten_US
dc.subject.meshAlpha 1-Antitrypsin - Analysis - Metabolismen_US
dc.titleEvaluation of performance of measurement of faecal α 1- antitrypsin clearance and technetium-99m human serum albumin scintigraphy in protein-losing enteropathyen_US
dc.typeArticleen_US
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_US
dc.identifier.authorityMok, MY=rp00490en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000327914en_US
dc.identifier.pmid21757911-
dc.identifier.scopuseid_2-s2.0-79960258894en_US
dc.identifier.hkuros235706-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960258894&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume84en_US
dc.identifier.issue3en_US
dc.identifier.spage199en_US
dc.identifier.epage206en_US
dc.identifier.isiWOS:000295987400005-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridChau, TN=7102000078en_US
dc.identifier.scopusauthoridMok, MY=7006024184en_US
dc.identifier.scopusauthoridChan, EYT=7401994013en_US
dc.identifier.scopusauthoridLuk, WH=8229666500en_US
dc.identifier.scopusauthoridLai, KB=36614177400en_US
dc.identifier.scopusauthoridLi, FTW=36466648100en_US
dc.identifier.scopusauthoridLeung, VKS=7102336049en_US
dc.identifier.scopusauthoridWong, R=7402127302en_US

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