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Article: Enteropathy-associated T-cell lymphoma: Clinical and histological findings from the international peripheral T-Cell lymphoma project

TitleEnteropathy-associated T-cell lymphoma: Clinical and histological findings from the international peripheral T-Cell lymphoma project
Authors
Issue Date2011
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 2011, v. 118 n. 1, p. 148-155 How to Cite?
AbstractFew large, international series of enteropathy-associated T-cell lymphoma (EATL) have been reported. We studied a cohort of 62 patients with EATL among 1153 patients with peripheral T-cell or natural killer (NK) - cell lymphoma from 22 centers worldwide. The diagnosis was made by a consensus panel of 4 expert hematopathologists using World Health Organization (WHO) criteria. Clinical correlations and survival analyses were performed. EATL comprised 5.4% of all lymphomas in the study and was most common in Europe (9.1%), followed by North America (5.8%) and Asia (1.9%). EATL type 1 was more common (66%) than type 2 (34%), and was especially frequent in Europe (79%). A clinical diagnosis of celiac sprue was made in 32.2% of the patients and was associated with both EATL type 1 and type 2. The median overall survival was only 10 months, and the median failure-free survival was only 6 months. The International Prognostic Index (IPI) was not as good a predictor of survival as the Prognostic Index for Peripheral T-Cell Lymphoma (PIT). Clinical sprue predicted for adverse survival independently of the PIT. Neither EATL subtype nor other biologic parameters accurately predicted survival. Our study confirms the poor prognosis of patients with EATL and the need for improved treatment options.
Persistent Identifierhttp://hdl.handle.net/10722/163384
ISSN
2014 Impact Factor: 10.452
2014 SCImago Journal Rankings: 5.246
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDelabie, Jen_US
dc.contributor.authorHolte, Hen_US
dc.contributor.authorVose, JMen_US
dc.contributor.authorUllrich, Fen_US
dc.contributor.authorJaffe, ESen_US
dc.contributor.authorSavage, KJen_US
dc.contributor.authorConnors, JMen_US
dc.contributor.authorRimsza, Len_US
dc.contributor.authorHarris, NLen_US
dc.contributor.authorMüllerHermelink, Ken_US
dc.contributor.authorRüdiger, Ten_US
dc.contributor.authorCoiffier, Ben_US
dc.contributor.authorGascoyne, RDen_US
dc.contributor.authorBerger, Fen_US
dc.contributor.authorTobinai, Ken_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorLiang, Ren_US
dc.contributor.authorMontserrat, Een_US
dc.contributor.authorHochberg, EPen_US
dc.contributor.authorPileri, Sen_US
dc.contributor.authorFederico, Men_US
dc.contributor.authorNathwani, Ben_US
dc.contributor.authorArmitage, JOen_US
dc.contributor.authorWeisenburger, DDen_US
dc.date.accessioned2012-09-05T05:30:44Z-
dc.date.available2012-09-05T05:30:44Z-
dc.date.issued2011en_US
dc.identifier.citationBlood, 2011, v. 118 n. 1, p. 148-155en_US
dc.identifier.issn0006-4971en_US
dc.identifier.urihttp://hdl.handle.net/10722/163384-
dc.description.abstractFew large, international series of enteropathy-associated T-cell lymphoma (EATL) have been reported. We studied a cohort of 62 patients with EATL among 1153 patients with peripheral T-cell or natural killer (NK) - cell lymphoma from 22 centers worldwide. The diagnosis was made by a consensus panel of 4 expert hematopathologists using World Health Organization (WHO) criteria. Clinical correlations and survival analyses were performed. EATL comprised 5.4% of all lymphomas in the study and was most common in Europe (9.1%), followed by North America (5.8%) and Asia (1.9%). EATL type 1 was more common (66%) than type 2 (34%), and was especially frequent in Europe (79%). A clinical diagnosis of celiac sprue was made in 32.2% of the patients and was associated with both EATL type 1 and type 2. The median overall survival was only 10 months, and the median failure-free survival was only 6 months. The International Prognostic Index (IPI) was not as good a predictor of survival as the Prognostic Index for Peripheral T-Cell Lymphoma (PIT). Clinical sprue predicted for adverse survival independently of the PIT. Neither EATL subtype nor other biologic parameters accurately predicted survival. Our study confirms the poor prognosis of patients with EATL and the need for improved treatment options.en_US
dc.languageengen_US
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_US
dc.relation.ispartofBlooden_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCeliac Disease - Classification - Mortality - Pathologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshConsensusen_US
dc.subject.meshEnteropathy-Associated T-Cell Lymphoma - Classification - Mortality - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInternationalityen_US
dc.subject.meshKiller Cells, Natural - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshT-Lymphocytes - Pathologyen_US
dc.subject.meshWorld Health Organizationen_US
dc.titleEnteropathy-associated T-cell lymphoma: Clinical and histological findings from the international peripheral T-Cell lymphoma projecten_US
dc.typeArticleen_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1182/blood-2011-02-335216en_US
dc.identifier.pmid21566094-
dc.identifier.scopuseid_2-s2.0-79960117770en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960117770&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume118en_US
dc.identifier.issue1en_US
dc.identifier.spage148en_US
dc.identifier.epage155en_US
dc.identifier.isiWOS:000292505900021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDelabie, J=7005309170en_US
dc.identifier.scopusauthoridHolte, H=7005680660en_US
dc.identifier.scopusauthoridVose, JM=35239028600en_US
dc.identifier.scopusauthoridUllrich, F=6701437438en_US
dc.identifier.scopusauthoridJaffe, ES=35392753200en_US
dc.identifier.scopusauthoridSavage, KJ=7005143534en_US
dc.identifier.scopusauthoridConnors, JM=7102927698en_US
dc.identifier.scopusauthoridRimsza, L=6603752603en_US
dc.identifier.scopusauthoridHarris, NL=7402548338en_US
dc.identifier.scopusauthoridMüllerHermelink, K=6602989280en_US
dc.identifier.scopusauthoridRüdiger, T=7004596094en_US
dc.identifier.scopusauthoridCoiffier, B=35395104000en_US
dc.identifier.scopusauthoridGascoyne, RD=7006757172en_US
dc.identifier.scopusauthoridBerger, F=35398977100en_US
dc.identifier.scopusauthoridTobinai, K=7005714992en_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridMontserrat, E=7102612356en_US
dc.identifier.scopusauthoridHochberg, EP=7003447051en_US
dc.identifier.scopusauthoridPileri, S=36041985800en_US
dc.identifier.scopusauthoridFederico, M=7101629810en_US
dc.identifier.scopusauthoridNathwani, B=35447962500en_US
dc.identifier.scopusauthoridArmitage, JO=7202699346en_US
dc.identifier.scopusauthoridWeisenburger, DD=7102337715en_US
dc.identifier.citeulike9564667-

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