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Article: Long-term clinical outcomes after intravascular brachytherapy for instent restenosis and de novo coronary artery lesions in percutaneous coronary intervention

TitleLong-term clinical outcomes after intravascular brachytherapy for instent restenosis and de novo coronary artery lesions in percutaneous coronary intervention
Authors
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/carrev
Citation
Cardiovascular Revascularization Medicine, 2011, v. 12 n. 3, p. 152-157 How to Cite?
AbstractBackground: We examined the long term clinical outcomes after administration of intravascular brachytherapy (IVBT) for instent restenosis (ISR) and de novo coronary artery lesions in percutaneous coronary intervention (PCI). Methods and Materials: From May 2000 to August 2004, 129 symptomatic patients with ISR and de novo coronary artery lesions were treated with intravascular beta radiation after successful PCI. The primary end-point was major adverse cardiac event (MACE), i.e., a composite of all-cause death, myocardial infarction and target lesion revascularization (TLR) within 5 years of follow-up. Results: The mean age of patients was 64+10 years with a male predominance (78%). The majority of patients had diffuse bare metal instent restenotic lesions and 19 patients (15%) had de novo coronary artery lesions. From hospital discharge to follow-up at 5 years (mean follow-up period 75.3. +17.7 months), the annual consecutive MACE rates were 16.3%, 13.4%, 8%, 12.2% and 6.6% respectively and were mainly driven by the need for TLR. Left anterior descending artery (LAD) as target vessel of PCI was an independent predictor of long term MACE (OR: 3.5; 95% confidence interval:1.2-10.6; P=03). There were six cases of stent thrombosis (cumulative incidence of 4.7%) with case fatality rate of 33% (2/6). Conclusion: MACE rates remained high post IVBT at 5 years of follow-up and were mainly driven by the need for TLR. LAD as target vessel of PCI was an independent predictor of long term MACE. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/163376
ISSN
2015 SCImago Journal Rankings: 0.583
References

 

DC FieldValueLanguage
dc.contributor.authorHo, HHen_US
dc.contributor.authorKwok, OHen_US
dc.contributor.authorJim, MHen_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorPong, Ven_US
dc.contributor.authorChow, WHen_US
dc.date.accessioned2012-09-05T05:30:41Z-
dc.date.available2012-09-05T05:30:41Z-
dc.date.issued2011en_US
dc.identifier.citationCardiovascular Revascularization Medicine, 2011, v. 12 n. 3, p. 152-157en_US
dc.identifier.issn1553-8389en_US
dc.identifier.urihttp://hdl.handle.net/10722/163376-
dc.description.abstractBackground: We examined the long term clinical outcomes after administration of intravascular brachytherapy (IVBT) for instent restenosis (ISR) and de novo coronary artery lesions in percutaneous coronary intervention (PCI). Methods and Materials: From May 2000 to August 2004, 129 symptomatic patients with ISR and de novo coronary artery lesions were treated with intravascular beta radiation after successful PCI. The primary end-point was major adverse cardiac event (MACE), i.e., a composite of all-cause death, myocardial infarction and target lesion revascularization (TLR) within 5 years of follow-up. Results: The mean age of patients was 64+10 years with a male predominance (78%). The majority of patients had diffuse bare metal instent restenotic lesions and 19 patients (15%) had de novo coronary artery lesions. From hospital discharge to follow-up at 5 years (mean follow-up period 75.3. +17.7 months), the annual consecutive MACE rates were 16.3%, 13.4%, 8%, 12.2% and 6.6% respectively and were mainly driven by the need for TLR. Left anterior descending artery (LAD) as target vessel of PCI was an independent predictor of long term MACE (OR: 3.5; 95% confidence interval:1.2-10.6; P=03). There were six cases of stent thrombosis (cumulative incidence of 4.7%) with case fatality rate of 33% (2/6). Conclusion: MACE rates remained high post IVBT at 5 years of follow-up and were mainly driven by the need for TLR. LAD as target vessel of PCI was an independent predictor of long term MACE. © 2011 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/carreven_US
dc.relation.ispartofCardiovascular Revascularization Medicineen_US
dc.subject.meshAgeden_US
dc.subject.meshAngioplasty, Balloon, Coronary - Adverse Effects - Instrumentation - Mortalityen_US
dc.subject.meshBrachytherapy - Adverse Effectsen_US
dc.subject.meshCoronary Restenosis - Etiology - Mortality - Radiotherapyen_US
dc.subject.meshCoronary Stenosis - Radiotherapy - Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshKaplan-Meier Estimateen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Infarction - Etiologyen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshProsthesis Designen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStentsen_US
dc.subject.meshThrombosis - Etiologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleLong-term clinical outcomes after intravascular brachytherapy for instent restenosis and de novo coronary artery lesions in percutaneous coronary interventionen_US
dc.typeArticleen_US
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.carrev.2010.08.003en_US
dc.identifier.pmid21640933-
dc.identifier.scopuseid_2-s2.0-79957877564en_US
dc.identifier.hkuros208708-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957877564&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue3en_US
dc.identifier.spage152en_US
dc.identifier.epage157en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, HH=35209997400en_US
dc.identifier.scopusauthoridKwok, OH=7004955826en_US
dc.identifier.scopusauthoridJim, MH=6603860344en_US
dc.identifier.scopusauthoridSiu, CW=7006550690en_US
dc.identifier.scopusauthoridPong, V=26025247300en_US
dc.identifier.scopusauthoridChow, WH=7402281062en_US

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