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Article: Extranodal natural-killer/T-cell lymphoma, nasal type

TitleExtranodal natural-killer/T-cell lymphoma, nasal type
Authors
Issue Date2010
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ah/
Citation
Advances In Hematology, 2010, v. 2010, article no. 627401 How to Cite?
AbstractThe World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia. Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America. Histopathological and immunophenotypical hallmarks include angiocentricity, angiodestruction, expression of cytoplasmic CD3 epsilon (ε), CD56, and cytotoxic molecules and evidence of Epstein-Barr virus (EBV) infection. Early stage disease, in particular for localized lesion in the nasal region, is treated with chemotherapy and involved-field radiotherapy. On the other hand, multiagent chemotherapy is the mainstay of treatment for advanced or disseminated disease. L-asparaginase-containing regimens have shown promise in treating this condition. The role of autologous hematopoietic stem cell transplantation is yet to be clearly defined. Allogeneic hematopoietic stem cell transplantation, with the putative graft-versus-lymphoma effect, offers a potentially curative option in patients with advanced disease. © 2010 Harinder Gill et al.
Persistent Identifierhttp://hdl.handle.net/10722/163368
ISSN
2015 SCImago Journal Rankings: 0.892
References

 

DC FieldValueLanguage
dc.contributor.authorGill, Hen_US
dc.contributor.authorLiang, RHSen_US
dc.contributor.authorTse, Een_US
dc.date.accessioned2012-09-05T05:30:38Z-
dc.date.available2012-09-05T05:30:38Z-
dc.date.issued2010en_US
dc.identifier.citationAdvances In Hematology, 2010, v. 2010, article no. 627401en_US
dc.identifier.issn1687-9104en_US
dc.identifier.urihttp://hdl.handle.net/10722/163368-
dc.description.abstractThe World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia. Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America. Histopathological and immunophenotypical hallmarks include angiocentricity, angiodestruction, expression of cytoplasmic CD3 epsilon (ε), CD56, and cytotoxic molecules and evidence of Epstein-Barr virus (EBV) infection. Early stage disease, in particular for localized lesion in the nasal region, is treated with chemotherapy and involved-field radiotherapy. On the other hand, multiagent chemotherapy is the mainstay of treatment for advanced or disseminated disease. L-asparaginase-containing regimens have shown promise in treating this condition. The role of autologous hematopoietic stem cell transplantation is yet to be clearly defined. Allogeneic hematopoietic stem cell transplantation, with the putative graft-versus-lymphoma effect, offers a potentially curative option in patients with advanced disease. © 2010 Harinder Gill et al.en_US
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ah/en_US
dc.relation.ispartofAdvances in Hematologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleExtranodal natural-killer/T-cell lymphoma, nasal typeen_US
dc.typeArticleen_US
dc.identifier.emailTse, E:ewctse@hku.hken_US
dc.identifier.emailLiang, RHS:rliang@hku.hken_US
dc.identifier.authorityTse, E=rp00471en_US
dc.identifier.authorityLiang, RHS=rp00345en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1155/2010/627401en_US
dc.identifier.scopuseid_2-s2.0-79952226950en_US
dc.identifier.hkuros207912-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952226950&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2010en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTse, E=7005019454en_US
dc.identifier.scopusauthoridGill, H=36113286500en_US
dc.identifier.scopusauthoridLiang, RHS=26643224900en_US
dc.identifier.citeulike8627049-

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