File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Bone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population

TitleBone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population
Authors
KeywordsBone mineral density
Genetics
Linkage
Microsatellite
Osteoporosis
Issue Date2011
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htm
Citation
Journal Of Bone And Mineral Metabolism, 2011, v. 29 n. 1, p. 80-87 How to Cite?
AbstractGenome-wide linkage scans have identified a number of quantitative trait loci (QTLs) affecting bone mineral density (BMD), mainly in the Caucasian population. In this study, we aim to determine whether seven well-replicated QTLs also contribute to BMD variation in the southern Han Chinese population. Thirty-three microsatellite markers in the proximity of seven QTLs were genotyped in 1,459 subjects from 306 families ascertained through a proband with BMD Z-score equal to or less than -1.3 at either the lumbar spine or hip. Regression-based multipoint linkage analysis was performed. In the entire study population, good linkage evidence of total hip BMD to 7p14 [maximum log of odds (LOD) score (MLS) = 2.75; nominal P = 0.0002] and 1p36 (MLS = 1.6, P = 0.003) was revealed. In the subgroup analysis of 1,166 female subjects, MLS of 3.42, 2.65, 2.42, and 1.54 were obtained on 7p12 for total hip, lumbar spine, trochanter, and femoral neck BMD, respectively. A suggestive linkage signal was achieved at 7p14-15 with a MLS of 3.38 and 3.15 for trochanter and total hip BMD in the 678 premenopausal women, and at 7p12 for femoral neck and total hip BMD with MLS of 2.22 and 3.04 in postmenopausal women. Subgroup analysis of premenopausal women also provided additional evidence of suggestive linkage of total hip BMD to 1p36, with a MLS of 2.84 at 17.07 cM. Thus, linkage of BMD to 1p36 and 7p15-13 is confirmed in southern Chinese. Computational prioritization strategy and published genome-wide association studies suggested RERE and SFRP4 as two promising candidate genes in which variants responsible for the linkage signal may be identified by follow-up gene-wide association studies. © 2010 The Japanese Society for Bone and Mineral Research and Springer.
Persistent Identifierhttp://hdl.handle.net/10722/163362
ISSN
2015 Impact Factor: 2.312
2015 SCImago Journal Rankings: 0.775
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, HYGen_HK
dc.contributor.authorKung, WCAen_HK
dc.contributor.authorHuang, QYen_HK
dc.date.accessioned2012-09-05T05:30:34Z-
dc.date.available2012-09-05T05:30:34Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Bone And Mineral Metabolism, 2011, v. 29 n. 1, p. 80-87en_HK
dc.identifier.issn0914-8779en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163362-
dc.description.abstractGenome-wide linkage scans have identified a number of quantitative trait loci (QTLs) affecting bone mineral density (BMD), mainly in the Caucasian population. In this study, we aim to determine whether seven well-replicated QTLs also contribute to BMD variation in the southern Han Chinese population. Thirty-three microsatellite markers in the proximity of seven QTLs were genotyped in 1,459 subjects from 306 families ascertained through a proband with BMD Z-score equal to or less than -1.3 at either the lumbar spine or hip. Regression-based multipoint linkage analysis was performed. In the entire study population, good linkage evidence of total hip BMD to 7p14 [maximum log of odds (LOD) score (MLS) = 2.75; nominal P = 0.0002] and 1p36 (MLS = 1.6, P = 0.003) was revealed. In the subgroup analysis of 1,166 female subjects, MLS of 3.42, 2.65, 2.42, and 1.54 were obtained on 7p12 for total hip, lumbar spine, trochanter, and femoral neck BMD, respectively. A suggestive linkage signal was achieved at 7p14-15 with a MLS of 3.38 and 3.15 for trochanter and total hip BMD in the 678 premenopausal women, and at 7p12 for femoral neck and total hip BMD with MLS of 2.22 and 3.04 in postmenopausal women. Subgroup analysis of premenopausal women also provided additional evidence of suggestive linkage of total hip BMD to 1p36, with a MLS of 2.84 at 17.07 cM. Thus, linkage of BMD to 1p36 and 7p15-13 is confirmed in southern Chinese. Computational prioritization strategy and published genome-wide association studies suggested RERE and SFRP4 as two promising candidate genes in which variants responsible for the linkage signal may be identified by follow-up gene-wide association studies. © 2010 The Japanese Society for Bone and Mineral Research and Springer.en_HK
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htmen_HK
dc.relation.ispartofJournal of Bone and Mineral Metabolismen_HK
dc.subjectBone mineral densityen_HK
dc.subjectGeneticsen_HK
dc.subjectLinkageen_HK
dc.subjectMicrosatelliteen_HK
dc.subjectOsteoporosisen_HK
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFemur - Metabolismen_US
dc.subject.meshFemur Neck - Metabolismen_US
dc.subject.meshGenetic Linkage - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLumbar Vertebrae - Metabolismen_US
dc.subject.meshMicrosatellite Repeats - Geneticsen_US
dc.subject.meshQuantitative Trait Loci - Geneticsen_US
dc.titleBone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.emailKung, WCA: awckung@hku.hken_HK
dc.identifier.emailHuang, QY: qyhuang@hotmail.comen_HK
dc.identifier.authorityKung, WCA=rp00368en_HK
dc.identifier.authorityHuang, QY=rp00521en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00774-010-0195-yen_HK
dc.identifier.pmid20607328-
dc.identifier.scopuseid_2-s2.0-79951608072en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951608072&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue1en_HK
dc.identifier.spage80en_HK
dc.identifier.epage87en_HK
dc.identifier.isiWOS:000286119000010-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridLi, HYG=37665276800en_HK
dc.identifier.scopusauthoridKung, WCA=7102322339en_HK
dc.identifier.scopusauthoridHuang, QY=7403630787en_HK
dc.identifier.citeulike7475002-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats