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Article: Hematopoietic stem cell transplantation in natural killer cell lymphoma and leukemia

TitleHematopoietic stem cell transplantation in natural killer cell lymphoma and leukemia
Authors
Issue Date2010
Citation
International Journal Of Hematology, 2010, v. 92 n. 5, p. 702-707 How to Cite?
AbstractNatural killer (NK) cell lymphomas and leukemias are aggressive neoplasms. Clinically, they can be classified into nasal, non-nasal and lymphoma/leukemia subtypes. Treatment results are unfavorable. High-dose chemotherapy and hematopoietic stem cell transplantation (HSCT) may improve patient outcome. For autologous HSCT, a critical review of the literature shows that most patients with nasal NK cell lymphoma in complete remission (CR) appear to do well without HSCT. However, patients with refractory diseases and untreated relapses have poor outcome with HSCT. Therefore, identification of patients with nasal NK cell lymphoma in CR who are at high risk of relapse may be necessary before autologous HSCT can be recommended. Patients with disseminated nasal NK cell lymphoma, non-nasal NK cell lymphoma and NK cell leukemia have poor outcome with autologous HSCT. Allogeneic HSCT may be beneficial to these patients. Most of the reported cases have been performed from HLA-identical sibling donors, and data on alternative HSC sources including matched unrelated donors and umbilical cord blood are very limited. Continuous efforts should be devoted to risk stratification for identifying high-risk individuals for HSCT, and defining the optimal conditioning regimen for NK cell lymphomas. © 2010 The Japanese Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/163355
ISSN
2015 Impact Factor: 1.846
2015 SCImago Journal Rankings: 0.779
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:30:27Z-
dc.date.available2012-09-05T05:30:27Z-
dc.date.issued2010en_US
dc.identifier.citationInternational Journal Of Hematology, 2010, v. 92 n. 5, p. 702-707en_US
dc.identifier.issn0925-5710en_US
dc.identifier.urihttp://hdl.handle.net/10722/163355-
dc.description.abstractNatural killer (NK) cell lymphomas and leukemias are aggressive neoplasms. Clinically, they can be classified into nasal, non-nasal and lymphoma/leukemia subtypes. Treatment results are unfavorable. High-dose chemotherapy and hematopoietic stem cell transplantation (HSCT) may improve patient outcome. For autologous HSCT, a critical review of the literature shows that most patients with nasal NK cell lymphoma in complete remission (CR) appear to do well without HSCT. However, patients with refractory diseases and untreated relapses have poor outcome with HSCT. Therefore, identification of patients with nasal NK cell lymphoma in CR who are at high risk of relapse may be necessary before autologous HSCT can be recommended. Patients with disseminated nasal NK cell lymphoma, non-nasal NK cell lymphoma and NK cell leukemia have poor outcome with autologous HSCT. Allogeneic HSCT may be beneficial to these patients. Most of the reported cases have been performed from HLA-identical sibling donors, and data on alternative HSC sources including matched unrelated donors and umbilical cord blood are very limited. Continuous efforts should be devoted to risk stratification for identifying high-risk individuals for HSCT, and defining the optimal conditioning regimen for NK cell lymphomas. © 2010 The Japanese Society of Hematology.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Hematologyen_US
dc.subject.meshDrug Therapyen_US
dc.subject.meshHematopoietic Stem Cell Transplantationen_US
dc.subject.meshHumansen_US
dc.subject.meshKiller Cells, Natural - Pathologyen_US
dc.subject.meshLeukemia - Diagnosis - Therapyen_US
dc.subject.meshLymphoma - Diagnosis - Therapyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTransplantation, Autologousen_US
dc.subject.meshTransplantation, Homologousen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleHematopoietic stem cell transplantation in natural killer cell lymphoma and leukemiaen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12185-010-0724-4en_US
dc.identifier.pmid21107769-
dc.identifier.scopuseid_2-s2.0-78751591483en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78751591483&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume92en_US
dc.identifier.issue5en_US
dc.identifier.spage702en_US
dc.identifier.epage707en_US
dc.identifier.isiWOS:000285152900005-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.citeulike8337650-

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