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Article: Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong

TitleGenetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong
Authors
Issue Date2010
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJH
Citation
European Journal Of Haematology, 2010, v. 85 n. 6, p. 492-495 How to Cite?
AbstractThe genetic basis of chronic lymphocytic leukemia (CLL) has not been fully elucidated to date. Although it is the most common haematological malignancy in Caucasians, it is uncommon among Asians. A recent genome-wide scan of CLL in Caucasians, which was carried out in the UK, identified six variants showing strong association. We attempted to replicate these findings in 71 patients with CLL and 1273 controls in Hong Kong Chinese. Three of the six variants were significantly associated with CLL. The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study. Polymorphisms in SP140 and ACOXL were also associated with risk of CLL. Further, the mean allele frequencies of the six variants were moderately (59%) to extremely (0.5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/163344
ISSN
2015 Impact Factor: 2.544
2015 SCImago Journal Rankings: 1.180
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLan, Qen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorChanock, Sen_US
dc.contributor.authorTse, Jen_US
dc.contributor.authorWong, KFen_US
dc.contributor.authorShen, Men_US
dc.contributor.authorSiu, LPen_US
dc.contributor.authorYuenger, Jen_US
dc.contributor.authorYeager, Men_US
dc.contributor.authorHosgood Iii, HDen_US
dc.contributor.authorPurdue, MPen_US
dc.contributor.authorLiang, Ren_US
dc.contributor.authorRothman, Nen_US
dc.date.accessioned2012-09-05T05:30:20Z-
dc.date.available2012-09-05T05:30:20Z-
dc.date.issued2010en_US
dc.identifier.citationEuropean Journal Of Haematology, 2010, v. 85 n. 6, p. 492-495en_US
dc.identifier.issn0902-4441en_US
dc.identifier.urihttp://hdl.handle.net/10722/163344-
dc.description.abstractThe genetic basis of chronic lymphocytic leukemia (CLL) has not been fully elucidated to date. Although it is the most common haematological malignancy in Caucasians, it is uncommon among Asians. A recent genome-wide scan of CLL in Caucasians, which was carried out in the UK, identified six variants showing strong association. We attempted to replicate these findings in 71 patients with CLL and 1273 controls in Hong Kong Chinese. Three of the six variants were significantly associated with CLL. The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study. Polymorphisms in SP140 and ACOXL were also associated with risk of CLL. Further, the mean allele frequencies of the six variants were moderately (59%) to extremely (0.5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese. © 2010 John Wiley & Sons A/S.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJHen_US
dc.relation.ispartofEuropean Journal of Haematologyen_US
dc.subject.meshAllelesen_US
dc.subject.meshAntigens, Nuclear - Geneticsen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequency - Geneticsen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon Regulatory Factors - Geneticsen_US
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell - Epidemiology - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTranscription Factors - Geneticsen_US
dc.titleGenetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0609.2010.01518.xen_US
dc.identifier.pmid20731705-
dc.identifier.scopuseid_2-s2.0-78349240663en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78349240663&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume85en_US
dc.identifier.issue6en_US
dc.identifier.spage492en_US
dc.identifier.epage495en_US
dc.identifier.isiWOS:000284165600004-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridLan, Q=23970641100en_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridChanock, S=7006047196en_US
dc.identifier.scopusauthoridTse, J=35068838000en_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US
dc.identifier.scopusauthoridShen, M=7401466176en_US
dc.identifier.scopusauthoridSiu, LP=7006651153en_US
dc.identifier.scopusauthoridYuenger, J=6508185395en_US
dc.identifier.scopusauthoridYeager, M=35379327500en_US
dc.identifier.scopusauthoridHosgood III, HD=15019273100en_US
dc.identifier.scopusauthoridPurdue, MP=6701653966en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridRothman, N=34572851700en_US

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