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Article: KCNQ1 and type 2 diabetes: Study in Hubei Han Chinese and meta-analysis in East Asian populations

TitleKCNQ1 and type 2 diabetes: Study in Hubei Han Chinese and meta-analysis in East Asian populations
Authors
KeywordsAssociation
KCNQ1
Single nucleotide polmorphism
Type 2 diabetes
Issue Date2010
Citation
Genes And Genomics, 2010, v. 32 n. 4, p. 327-334 How to Cite?
AbstractRecent genome-wide association studies in East Asian poulations reported the association of KCNQ1 variants with type 2 diabetes. In the present study, we first investigated the association between rs2237892 in KCNQ1 and type 2 diabetes in a Hubei Han Chinese population (223 type 2 diabetes patients and 201 controls). The frequencies of CC genotype and C allele in type 2 diabetes patients were significantly higher than those of controls group (CC: 51.6% vs 39.3%, P=0.001; C: 72.2% vs 61.2%, P=0.001). The odds ratio for the risk allele C was 1.65 (95%CI 1.23-2.2, P=0.001). Then, we systematically reviewed the association of SNPs (rs2237892, rs2237895, rs2237897, rs2074196) in KCNQ1 with type 2 diabetes risk in a meta-analysis. Significant heterogeneity between studies was found for SNPs rs2237892 and rs2237897. Combined odds ratios of the rs2237892 C, rs2237895 C, rs2237897 C, rs2074196 G allele were 1.35 (95% CI 1.29-1.41, P<0.0001), 1.27 (95%CI 1.23-1.32, P<0.0001), 1.32 (95%CI 1.21-1.43, P<0.0001), 1.30 (95%CI 1.25-1.35, P<0.0001) respectively. Our results and meta-analysis demonstrated that KCNQ1 polymorphisms were reproducibly associated with the risk of type 2 diabetes in Han Chinese and East Asian populations. © 2010 The Genetics Society of Korea and Springer Netherlands.
Persistent Identifierhttp://hdl.handle.net/10722/163333
ISSN
2015 Impact Factor: 0.692
2015 SCImago Journal Rankings: 0.332
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDehwah, MASen_HK
dc.contributor.authorZhang, Sen_HK
dc.contributor.authorQu, Ken_HK
dc.contributor.authorHuang, Hen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorHuang, Qen_HK
dc.date.accessioned2012-09-05T05:30:08Z-
dc.date.available2012-09-05T05:30:08Z-
dc.date.issued2010en_HK
dc.identifier.citationGenes And Genomics, 2010, v. 32 n. 4, p. 327-334en_HK
dc.identifier.issn1976-9571en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163333-
dc.description.abstractRecent genome-wide association studies in East Asian poulations reported the association of KCNQ1 variants with type 2 diabetes. In the present study, we first investigated the association between rs2237892 in KCNQ1 and type 2 diabetes in a Hubei Han Chinese population (223 type 2 diabetes patients and 201 controls). The frequencies of CC genotype and C allele in type 2 diabetes patients were significantly higher than those of controls group (CC: 51.6% vs 39.3%, P=0.001; C: 72.2% vs 61.2%, P=0.001). The odds ratio for the risk allele C was 1.65 (95%CI 1.23-2.2, P=0.001). Then, we systematically reviewed the association of SNPs (rs2237892, rs2237895, rs2237897, rs2074196) in KCNQ1 with type 2 diabetes risk in a meta-analysis. Significant heterogeneity between studies was found for SNPs rs2237892 and rs2237897. Combined odds ratios of the rs2237892 C, rs2237895 C, rs2237897 C, rs2074196 G allele were 1.35 (95% CI 1.29-1.41, P<0.0001), 1.27 (95%CI 1.23-1.32, P<0.0001), 1.32 (95%CI 1.21-1.43, P<0.0001), 1.30 (95%CI 1.25-1.35, P<0.0001) respectively. Our results and meta-analysis demonstrated that KCNQ1 polymorphisms were reproducibly associated with the risk of type 2 diabetes in Han Chinese and East Asian populations. © 2010 The Genetics Society of Korea and Springer Netherlands.en_HK
dc.languageengen_US
dc.relation.ispartofGenes and Genomicsen_HK
dc.subjectAssociationen_HK
dc.subjectKCNQ1en_HK
dc.subjectSingle nucleotide polmorphismen_HK
dc.subjectType 2 diabetesen_HK
dc.titleKCNQ1 and type 2 diabetes: Study in Hubei Han Chinese and meta-analysis in East Asian populationsen_HK
dc.typeArticleen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailHuang, Q: qyhuang@hotmail.comen_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityHuang, Q=rp00521en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s13258-010-0020-yen_HK
dc.identifier.scopuseid_2-s2.0-77956577895en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956577895&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue4en_HK
dc.identifier.spage327en_HK
dc.identifier.epage334en_HK
dc.identifier.isiWOS:000281669200005-
dc.identifier.scopusauthoridDehwah, MAS=24070520600en_HK
dc.identifier.scopusauthoridZhang, S=36699057700en_HK
dc.identifier.scopusauthoridQu, K=36698871300en_HK
dc.identifier.scopusauthoridHuang, H=14627541100en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridHuang, Q=7403630787en_HK

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