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Article: Relationship of adipocyte fatty acid-binding protein to adiponectin ratio with femoral intima-media thickness and endothelium-dependent vasodilation in patients with newly-diagnosed type 2 diabetes mellitus

TitleRelationship of adipocyte fatty acid-binding protein to adiponectin ratio with femoral intima-media thickness and endothelium-dependent vasodilation in patients with newly-diagnosed type 2 diabetes mellitus
Authors
Issue Date2010
Publisher中華醫學會. The Journal's web site is located at http://zhyx.chinajournal.net.cn/
Citation
Zhonghua Yi Xue Za Zhi, 2010, v. 90 n. 4, p. 231-235 How to Cite?
AbstractOBJECTIVE: To explore the relationship between plasma adipocyte fatty acid-binding protein (A-FABP), adiponectin (APN) levels and A-FABP/APN ratio with femoral intima-media thickness (FA-IMT) and endothelium-dependent vasodilation in patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: Plasma A-FABP and APN in 133 patients with newly diagnosed T2DM were measured by enzyme-linked immunosorbent assays. FA-IMT, endothelium-dependent and independent vasodilation of brachial artery was measured by high-resolution vascular ultrasound. Upper quartile of FA-IMT was regarded as a criterion of elevated FA-IMT, defined as early atherosclerosis (AS). The patients were subdivided into low FA-IMT group (FA-IMT < 0.60 mm, n = 34), middle FA-IMT group (0.60 mm /= 0.80 mm, n = 33). RESULTS: Plasma A-FABP/APN ratio was higher in early AS group than in low IMT control group [A-FABP/APN x 1000, 3.9(2.8 approximately 6.1) vs 2.9(1.8 approximately 5.7), P < 0.05]. FA-IMT correlated positively with plasma A-FABP/APN ratio (r = 0.216, P = 0.006) and negatively with APN (r = -0.179, P = 0.020). After adjusted for age, gender and BMI, FA-IMT still correlated positively with plasma A-FABP/APN ratio (r = 0.217, P = 0.007) and negatively with APN (r = -0.172, P = 0.026). Endothelium-dependent vasodilation correlated negatively with plasma A-FABP/APN ratio (r = -0.166, P = 0.028). After adjusted for age, gender and BMI, endothelium-dependent vasodilation still correlated negatively with plasma A-FABP/APN ratio (r = -0.153, P = 0.042). CONCLUSION: Plasma A-FABP/APN ratio is closely associated with FA-IMT and endothelium-dependent vasodilation. Plasma A-FABP/APN ratio may be a better clinical marker of AS and endothelial dysfunction than A-FABP or APN alone in patients with newly diagnosed T2DM.
Persistent Identifierhttp://hdl.handle.net/10722/163318
ISSN
2015 SCImago Journal Rankings: 0.134

 

DC FieldValueLanguage
dc.contributor.authorXiao, Yen_US
dc.contributor.authorYao, Len_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorZhong, Hen_US
dc.contributor.authorChen, XYen_US
dc.contributor.authorTang, WLen_US
dc.contributor.authorLiu, SPen_US
dc.contributor.authorXu, AMen_US
dc.contributor.authorZhou, ZGen_US
dc.date.accessioned2012-09-05T05:29:59Z-
dc.date.available2012-09-05T05:29:59Z-
dc.date.issued2010en_US
dc.identifier.citationZhonghua Yi Xue Za Zhi, 2010, v. 90 n. 4, p. 231-235en_US
dc.identifier.issn0376-2491en_US
dc.identifier.urihttp://hdl.handle.net/10722/163318-
dc.description.abstractOBJECTIVE: To explore the relationship between plasma adipocyte fatty acid-binding protein (A-FABP), adiponectin (APN) levels and A-FABP/APN ratio with femoral intima-media thickness (FA-IMT) and endothelium-dependent vasodilation in patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: Plasma A-FABP and APN in 133 patients with newly diagnosed T2DM were measured by enzyme-linked immunosorbent assays. FA-IMT, endothelium-dependent and independent vasodilation of brachial artery was measured by high-resolution vascular ultrasound. Upper quartile of FA-IMT was regarded as a criterion of elevated FA-IMT, defined as early atherosclerosis (AS). The patients were subdivided into low FA-IMT group (FA-IMT < 0.60 mm, n = 34), middle FA-IMT group (0.60 mm </= FA-IMT < 0.73 mm, n = 33), high FA-IMT group (0.73 mm </= FA-IMT < 0.80 mm, n = 33) and early AS group (FA-IMT >/= 0.80 mm, n = 33). RESULTS: Plasma A-FABP/APN ratio was higher in early AS group than in low IMT control group [A-FABP/APN x 1000, 3.9(2.8 approximately 6.1) vs 2.9(1.8 approximately 5.7), P < 0.05]. FA-IMT correlated positively with plasma A-FABP/APN ratio (r = 0.216, P = 0.006) and negatively with APN (r = -0.179, P = 0.020). After adjusted for age, gender and BMI, FA-IMT still correlated positively with plasma A-FABP/APN ratio (r = 0.217, P = 0.007) and negatively with APN (r = -0.172, P = 0.026). Endothelium-dependent vasodilation correlated negatively with plasma A-FABP/APN ratio (r = -0.166, P = 0.028). After adjusted for age, gender and BMI, endothelium-dependent vasodilation still correlated negatively with plasma A-FABP/APN ratio (r = -0.153, P = 0.042). CONCLUSION: Plasma A-FABP/APN ratio is closely associated with FA-IMT and endothelium-dependent vasodilation. Plasma A-FABP/APN ratio may be a better clinical marker of AS and endothelial dysfunction than A-FABP or APN alone in patients with newly diagnosed T2DM.en_US
dc.languageengen_US
dc.publisher中華醫學會. The Journal's web site is located at http://zhyx.chinajournal.net.cn/en_US
dc.relation.ispartofZhonghua yi xue za zhien_US
dc.subject.meshAdiponectin - Blooden_US
dc.subject.meshAgeden_US
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Pathology - Physiopathologyen_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshEndothelium-Dependent Relaxing Factors - Blooden_US
dc.subject.meshFatty Acid-Binding Proteins - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFemoral Artery - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleRelationship of adipocyte fatty acid-binding protein to adiponectin ratio with femoral intima-media thickness and endothelium-dependent vasodilation in patients with newly-diagnosed type 2 diabetes mellitusen_US
dc.typeArticleen_US
dc.identifier.emailXu, AM:amxu@hkucc.hku.hken_US
dc.identifier.authorityXu, AM=rp00485en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid20356535-
dc.identifier.scopuseid_2-s2.0-77953266049en_US
dc.identifier.volume90en_US
dc.identifier.issue4en_US
dc.identifier.spage231en_US
dc.identifier.epage235en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridXiao, Y=36464707600en_US
dc.identifier.scopusauthoridYao, L=36103474800en_US
dc.identifier.scopusauthoridLi, X=7501696265en_US
dc.identifier.scopusauthoridZhong, H=36103695600en_US
dc.identifier.scopusauthoridChen, XY=13308429200en_US
dc.identifier.scopusauthoridTang, WL=7403430885en_US
dc.identifier.scopusauthoridLiu, SP=9249830600en_US
dc.identifier.scopusauthoridXu, AM=7202655409en_US
dc.identifier.scopusauthoridZhou, ZG=8417885800en_US

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