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Article: Disorders of glucose metabolism in sleep-disordered breathing
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TitleDisorders of glucose metabolism in sleep-disordered breathing
 
AuthorsLui, MMS1
Ip, MSM1
 
Issue Date2010
 
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cchm
 
CitationClinics In Chest Medicine, 2010, v. 31 n. 2, p. 271-285 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ccm.2010.02.001
 
AbstractDespite proliferating literature, the exact relationship between obstructive sleep apnea (OSA) and alterations in glucose metabolism is still controversial. There is growing evidence to suggest that OSA imposes adverse effects on glucose metabolism, but the translation into clinical effect is not well delineated. Many potential mechanisms are being explored, mostly relating to peripheral tissue response to insulin and more recently regarding pancreatic β cell function of insulin secretion. The effect of OSA on glucose metabolism is likely to be influenced by many personal characteristics. Age, degree of adiposity, lifestyle, comorbidities, and even the stage of glucose disorder itself may modify the relationship between OSA and glucose metabolism. In the biologic system of the human body, all these interact to culminate in clinically relevant outcomes. © 2010 Elsevier Inc.
 
ISSN0272-5231
2013 Impact Factor: 2.168
2013 SCImago Journal Rankings: 0.905
 
DOIhttp://dx.doi.org/10.1016/j.ccm.2010.02.001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLui, MMS
 
dc.contributor.authorIp, MSM
 
dc.date.accessioned2012-09-05T05:29:58Z
 
dc.date.available2012-09-05T05:29:58Z
 
dc.date.issued2010
 
dc.description.abstractDespite proliferating literature, the exact relationship between obstructive sleep apnea (OSA) and alterations in glucose metabolism is still controversial. There is growing evidence to suggest that OSA imposes adverse effects on glucose metabolism, but the translation into clinical effect is not well delineated. Many potential mechanisms are being explored, mostly relating to peripheral tissue response to insulin and more recently regarding pancreatic β cell function of insulin secretion. The effect of OSA on glucose metabolism is likely to be influenced by many personal characteristics. Age, degree of adiposity, lifestyle, comorbidities, and even the stage of glucose disorder itself may modify the relationship between OSA and glucose metabolism. In the biologic system of the human body, all these interact to culminate in clinically relevant outcomes. © 2010 Elsevier Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinics In Chest Medicine, 2010, v. 31 n. 2, p. 271-285 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ccm.2010.02.001
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ccm.2010.02.001
 
dc.identifier.epage285
 
dc.identifier.issn0272-5231
2013 Impact Factor: 2.168
2013 SCImago Journal Rankings: 0.905
 
dc.identifier.issue2
 
dc.identifier.pmid20488286
 
dc.identifier.scopuseid_2-s2.0-77952928098
 
dc.identifier.spage271
 
dc.identifier.urihttp://hdl.handle.net/10722/163317
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cchm
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinics in Chest Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnoxia - Physiopathology
 
dc.subject.meshAutonomic Nervous System - Physiopathology
 
dc.subject.meshBlood Glucose - Analysis
 
dc.subject.meshContinuous Positive Airway Pressure
 
dc.subject.meshCytokines - Metabolism
 
dc.subject.meshDiabetes Mellitus - Metabolism
 
dc.subject.meshDiabetes Mellitus, Type 2 - Metabolism
 
dc.subject.meshFatty Acid-Binding Proteins - Physiology
 
dc.subject.meshHumans
 
dc.subject.meshInsulin Resistance
 
dc.subject.meshSleep Apnea Syndromes - Metabolism
 
dc.subject.meshSleep Apnea, Obstructive - Metabolism - Therapy
 
dc.subject.meshSleep Deprivation - Physiopathology
 
dc.titleDisorders of glucose metabolism in sleep-disordered breathing
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong