Article: Disorders of glucose metabolism in sleep-disordered breathing

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TitleDisorders of glucose metabolism in sleep-disordered breathing
AuthorsLui, MMS1
Ip, MSM1
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cchm
CitationClinics In Chest Medicine, 2010, v. 31 n. 2, p. 271-285 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ccm.2010.02.001
AbstractDespite proliferating literature, the exact relationship between obstructive sleep apnea (OSA) and alterations in glucose metabolism is still controversial. There is growing evidence to suggest that OSA imposes adverse effects on glucose metabolism, but the translation into clinical effect is not well delineated. Many potential mechanisms are being explored, mostly relating to peripheral tissue response to insulin and more recently regarding pancreatic β cell function of insulin secretion. The effect of OSA on glucose metabolism is likely to be influenced by many personal characteristics. Age, degree of adiposity, lifestyle, comorbidities, and even the stage of glucose disorder itself may modify the relationship between OSA and glucose metabolism. In the biologic system of the human body, all these interact to culminate in clinically relevant outcomes. © 2010 Elsevier Inc.
ISSN0272-5231
2011 Impact Factor: 3.284
2011 SCImago Journal Rankings: 0.265
DOIhttp://dx.doi.org/10.1016/j.ccm.2010.02.001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLui, MMS
dc.contributor.authorIp, MSM
dc.date.accessioned2012-09-05T05:29:58Z
dc.date.available2012-09-05T05:29:58Z
dc.date.issued2010
dc.description.abstractDespite proliferating literature, the exact relationship between obstructive sleep apnea (OSA) and alterations in glucose metabolism is still controversial. There is growing evidence to suggest that OSA imposes adverse effects on glucose metabolism, but the translation into clinical effect is not well delineated. Many potential mechanisms are being explored, mostly relating to peripheral tissue response to insulin and more recently regarding pancreatic β cell function of insulin secretion. The effect of OSA on glucose metabolism is likely to be influenced by many personal characteristics. Age, degree of adiposity, lifestyle, comorbidities, and even the stage of glucose disorder itself may modify the relationship between OSA and glucose metabolism. In the biologic system of the human body, all these interact to culminate in clinically relevant outcomes. © 2010 Elsevier Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationClinics In Chest Medicine, 2010, v. 31 n. 2, p. 271-285 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ccm.2010.02.001
dc.identifier.doihttp://dx.doi.org/10.1016/j.ccm.2010.02.001
dc.identifier.epage285
dc.identifier.issn0272-5231
2011 Impact Factor: 3.284
2011 SCImago Journal Rankings: 0.265
dc.identifier.issue2
dc.identifier.pmid20488286
dc.identifier.scopuseid_2-s2.0-77952928098
dc.identifier.spage271
dc.identifier.urihttp://hdl.handle.net/10722/163317
dc.identifier.volume31
dc.languageeng
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cchm
dc.publisher.placeUnited States
dc.relation.ispartofClinics in Chest Medicine
dc.relation.referencesReferences in Scopus
dc.subject.meshAnoxia - Physiopathology
dc.subject.meshAutonomic Nervous System - Physiopathology
dc.subject.meshBlood Glucose - Analysis
dc.subject.meshContinuous Positive Airway Pressure
dc.subject.meshCytokines - Metabolism
dc.subject.meshDiabetes Mellitus - Metabolism
dc.subject.meshDiabetes Mellitus, Type 2 - Metabolism
dc.subject.meshFatty Acid-Binding Proteins - Physiology
dc.subject.meshHumans
dc.subject.meshInsulin Resistance
dc.subject.meshSleep Apnea Syndromes - Metabolism
dc.subject.meshSleep Apnea, Obstructive - Metabolism - Therapy
dc.subject.meshSleep Deprivation - Physiopathology
dc.titleDisorders of glucose metabolism in sleep-disordered breathing
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong