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Article: Peritoneal adipocytes and their role in inflammation during peritoneal dialysis

TitlePeritoneal adipocytes and their role in inflammation during peritoneal dialysis
Authors
Issue Date2010
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/mi/index.html
Citation
Mediators Of Inflammation, 2010, v. 2010, article no. 495416 How to Cite?
AbstractAdipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD. © 2010 K. N. Lai and J. C. K. Leung.
Persistent Identifierhttp://hdl.handle.net/10722/163316
ISSN
2015 Impact Factor: 3.418
2015 SCImago Journal Rankings: 1.370
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLeung, JCKen_HK
dc.date.accessioned2012-09-05T05:29:58Z-
dc.date.available2012-09-05T05:29:58Z-
dc.date.issued2010en_HK
dc.identifier.citationMediators Of Inflammation, 2010, v. 2010, article no. 495416en_HK
dc.identifier.issn0962-9351en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163316-
dc.description.abstractAdipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD. © 2010 K. N. Lai and J. C. K. Leung.en_HK
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/mi/index.html-
dc.relation.ispartofMediators of Inflammationen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdipocytes - Cytology - Physiologyen_US
dc.subject.meshAdipokines - Physiologyen_US
dc.subject.meshAdipose Tissue - Physiologyen_US
dc.subject.meshAntigens, Cd - Analysisen_US
dc.subject.meshEndothelial Cells - Cytology - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation - Etiology - Physiopathologyen_US
dc.subject.meshLeptin - Physiologyen_US
dc.subject.meshPeritoneal Dialysis - Adverse Effectsen_US
dc.subject.meshPeritonitis - Physiopathologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRegenerationen_US
dc.subject.meshStem Cells - Cytology - Physiologyen_US
dc.titlePeritoneal adipocytes and their role in inflammation during peritoneal dialysisen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1155/2010/495416en_HK
dc.identifier.pmid20454534-
dc.identifier.scopuseid_2-s2.0-77952535604en_HK
dc.identifier.hkuros180806-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952535604&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2010en_HK
dc.identifier.isiWOS:000278510000001-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK

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