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Article: Peritoneal adipocytes and their role in inflammation during peritoneal dialysis
Title | Peritoneal adipocytes and their role in inflammation during peritoneal dialysis |
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Authors | |
Issue Date | 2010 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/mi/index.html |
Citation | Mediators Of Inflammation, 2010, v. 2010, article no. 495416 How to Cite? |
Abstract | Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD. © 2010 K. N. Lai and J. C. K. Leung. |
Persistent Identifier | http://hdl.handle.net/10722/163316 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.043 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lai, KN | en_HK |
dc.contributor.author | Leung, JCK | en_HK |
dc.date.accessioned | 2012-09-05T05:29:58Z | - |
dc.date.available | 2012-09-05T05:29:58Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Mediators Of Inflammation, 2010, v. 2010, article no. 495416 | en_HK |
dc.identifier.issn | 0962-9351 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163316 | - |
dc.description.abstract | Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD. © 2010 K. N. Lai and J. C. K. Leung. | en_HK |
dc.language | eng | en_US |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/mi/index.html | - |
dc.relation.ispartof | Mediators of Inflammation | en_HK |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.mesh | Adipocytes - Cytology - Physiology | en_US |
dc.subject.mesh | Adipokines - Physiology | en_US |
dc.subject.mesh | Adipose Tissue - Physiology | en_US |
dc.subject.mesh | Antigens, Cd - Analysis | en_US |
dc.subject.mesh | Endothelial Cells - Cytology - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inflammation - Etiology - Physiopathology | en_US |
dc.subject.mesh | Leptin - Physiology | en_US |
dc.subject.mesh | Peritoneal Dialysis - Adverse Effects | en_US |
dc.subject.mesh | Peritonitis - Physiopathology | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Rna, Messenger - Genetics | en_US |
dc.subject.mesh | Regeneration | en_US |
dc.subject.mesh | Stem Cells - Cytology - Physiology | en_US |
dc.title | Peritoneal adipocytes and their role in inflammation during peritoneal dialysis | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lai, KN: knlai@hku.hk | en_HK |
dc.identifier.email | Leung, JCK: jckleung@hku.hk | en_HK |
dc.identifier.authority | Lai, KN=rp00324 | en_HK |
dc.identifier.authority | Leung, JCK=rp00448 | en_HK |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1155/2010/495416 | en_HK |
dc.identifier.pmid | 20454534 | - |
dc.identifier.scopus | eid_2-s2.0-77952535604 | en_HK |
dc.identifier.hkuros | 180806 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77952535604&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 2010 | en_HK |
dc.identifier.isi | WOS:000278510000001 | - |
dc.publisher.place | United States | - |
dc.identifier.scopusauthorid | Lai, KN=7402135706 | en_HK |
dc.identifier.scopusauthorid | Leung, JCK=7202180349 | en_HK |
dc.identifier.issnl | 0962-9351 | - |