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Article: Prenatal diagnosis of homozygous α-thalassemia: From an invasive to a noninvasive approach

TitlePrenatal diagnosis of homozygous α-thalassemia: From an invasive to a noninvasive approach
Authors
Keywordsα-thalassemia
Blood transfusion
Intrauterine
Preimplantation genetic diagnosis
Prenatal diagnosis
Ultrasound
Issue Date2009
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eog
Citation
Expert Review Of Obstetrics And Gynecology, 2009, v. 4 n. 3, p. 321-329 How to Cite?
AbstractThe birth of babies with homozygous α-thalassemia can be prevented by prenatal screening and diagnosis. Serial ultrasound examination of fetal cardio-thoracic ratio and placental thickness can exclude an affected pregnancy and, thus, reduce the need for an invasive test. Whether middle cerebral artery Doppler is useful in the prediction is not clear. 3D ultrasound examination, maternal blood-smear screening for fetal hemoglobin Barts cells and maternal serum markers for Down syndrome have also been investigated. In view of the recent data on the survival of affected fetuses after in utero transfusion, it is arguable whether the latter should be offered as an alternative to termination of pregnancy after prenatal diagnosis. Preimplantation genetic diagnosis is possible, particularly for couples with repeatedly affected pregnancies. © 2009 Expert Reviews Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/163312
ISSN
2015 SCImago Journal Rankings: 0.215
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, KYen_HK
dc.contributor.authorCheong, KBen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorTang, MHen_HK
dc.contributor.authorLau, ETen_HK
dc.date.accessioned2012-09-05T05:29:57Z-
dc.date.available2012-09-05T05:29:57Z-
dc.date.issued2009en_HK
dc.identifier.citationExpert Review Of Obstetrics And Gynecology, 2009, v. 4 n. 3, p. 321-329en_HK
dc.identifier.issn1747-4108en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163312-
dc.description.abstractThe birth of babies with homozygous α-thalassemia can be prevented by prenatal screening and diagnosis. Serial ultrasound examination of fetal cardio-thoracic ratio and placental thickness can exclude an affected pregnancy and, thus, reduce the need for an invasive test. Whether middle cerebral artery Doppler is useful in the prediction is not clear. 3D ultrasound examination, maternal blood-smear screening for fetal hemoglobin Barts cells and maternal serum markers for Down syndrome have also been investigated. In view of the recent data on the survival of affected fetuses after in utero transfusion, it is arguable whether the latter should be offered as an alternative to termination of pregnancy after prenatal diagnosis. Preimplantation genetic diagnosis is possible, particularly for couples with repeatedly affected pregnancies. © 2009 Expert Reviews Ltd.en_HK
dc.languageengen_US
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eogen_HK
dc.relation.ispartofExpert Review of Obstetrics and Gynecologyen_HK
dc.subjectα-thalassemiaen_HK
dc.subjectBlood transfusionen_HK
dc.subjectIntrauterineen_HK
dc.subjectPreimplantation genetic diagnosisen_HK
dc.subjectPrenatal diagnosisen_HK
dc.subjectUltrasounden_HK
dc.titlePrenatal diagnosis of homozygous α-thalassemia: From an invasive to a noninvasive approachen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.emailTang, MH: mhytang@hkucc.hku.hken_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.identifier.authorityTang, MH=rp01701en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1586/eog.09.1en_HK
dc.identifier.scopuseid_2-s2.0-77951735250en_HK
dc.identifier.hkuros180845-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951735250&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue3en_HK
dc.identifier.spage321en_HK
dc.identifier.epage329en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, KY=8247106900en_HK
dc.identifier.scopusauthoridCheong, KB=26321364700en_HK
dc.identifier.scopusauthoridLee, CP=7410149538en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridTang, MH=35362943900en_HK
dc.identifier.scopusauthoridLau, ET=36006491400en_HK

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