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Article: Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients

TitleVariation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients
Authors
KeywordsCaucasian
Chinese
Genetic association study
IgA nephropathy
IGHMBP2
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
Nephrology Dialysis Transplantation, 2010, v. 25 n. 5, p. 1547-1554 How to Cite?
AbstractBackground. IgA nephropathy is a major cause of end-stage renal disease worldwide. Its aetiology is poorly understood but there is good evidence for a major genetic component, although to date, no gene has been conclusively identified. We describe a new UK multicentre DNA collection assembled to investigate this. A Japanese genome-wide analysis recently reported that common genetic variation in immunoglobulin mu-binding protein 2 (IGHMBP2) was associated with IgA nephropathy. We sought to replicate this using the new UK collection, and through an independent parallel analysis of a Han Chinese population.Methods. In the UK collection, haplotype-tagging (tag) single-nucleotide polymorphisms (SNPs) and haplotypes were analysed in a case-control study (349 cases, 605 controls) and family-based analysis (162 complete and 23 partially complete family trios), which was performed using the transmission disequilibrium test. In parallel, 663 cases of IgA nephropathy and 663 controls from a Chinese population were analysed: coding and flanking regions of the gene were re-sequenced in a subset, and SNP and haplotype association analysis was performed in the whole collection using the identified tagSNPs and all the coding and exonic flanking SNPs.Results. Case-control studies in UK and Chinese populations, and family-based tests in the UK population provided no evidence for association between variation in IGHMBP2 and IgA nephropathy. The A allele of SNP G34448A was not present in the UK collection. It was present but not associated with the disease in the Chinese population.Conclusion. Variation in IGHMBP2 does not confer significant susceptibility to IgA nephropathy in UK Caucasian or Chinese Han populations. © The Author 2009. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163311
ISSN
2015 Impact Factor: 4.085
2015 SCImago Journal Rankings: 1.780
ISI Accession Number ID
References
Errata

 

DC FieldValueLanguage
dc.contributor.authorLou, Ten_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorGale, DPen_HK
dc.contributor.authorRees, AJen_HK
dc.contributor.authorRhodes, Ben_HK
dc.contributor.authorFeehally, Jen_HK
dc.contributor.authorLi, Cen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorLi, Ren_HK
dc.contributor.authorHuang, Wen_HK
dc.contributor.authorHu, Ben_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorMaxwell, PHen_HK
dc.date.accessioned2012-09-05T05:29:57Z-
dc.date.available2012-09-05T05:29:57Z-
dc.date.issued2010en_HK
dc.identifier.citationNephrology Dialysis Transplantation, 2010, v. 25 n. 5, p. 1547-1554en_HK
dc.identifier.issn0931-0509en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163311-
dc.description.abstractBackground. IgA nephropathy is a major cause of end-stage renal disease worldwide. Its aetiology is poorly understood but there is good evidence for a major genetic component, although to date, no gene has been conclusively identified. We describe a new UK multicentre DNA collection assembled to investigate this. A Japanese genome-wide analysis recently reported that common genetic variation in immunoglobulin mu-binding protein 2 (IGHMBP2) was associated with IgA nephropathy. We sought to replicate this using the new UK collection, and through an independent parallel analysis of a Han Chinese population.Methods. In the UK collection, haplotype-tagging (tag) single-nucleotide polymorphisms (SNPs) and haplotypes were analysed in a case-control study (349 cases, 605 controls) and family-based analysis (162 complete and 23 partially complete family trios), which was performed using the transmission disequilibrium test. In parallel, 663 cases of IgA nephropathy and 663 controls from a Chinese population were analysed: coding and flanking regions of the gene were re-sequenced in a subset, and SNP and haplotype association analysis was performed in the whole collection using the identified tagSNPs and all the coding and exonic flanking SNPs.Results. Case-control studies in UK and Chinese populations, and family-based tests in the UK population provided no evidence for association between variation in IGHMBP2 and IgA nephropathy. The A allele of SNP G34448A was not present in the UK collection. It was present but not associated with the disease in the Chinese population.Conclusion. Variation in IGHMBP2 does not confer significant susceptibility to IgA nephropathy in UK Caucasian or Chinese Han populations. © The Author 2009. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/en_HK
dc.relation.ispartofNephrology Dialysis Transplantationen_HK
dc.subjectCaucasianen_HK
dc.subjectChineseen_HK
dc.subjectGenetic association studyen_HK
dc.subjectIgA nephropathyen_HK
dc.subjectIGHMBP2en_HK
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshDatabases, Geneticen_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlomerulonephritis, Iga - Geneticsen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshTranscription Factors - Geneticsen_US
dc.titleVariation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/ndt/gfp661en_HK
dc.identifier.pmid20031928-
dc.identifier.scopuseid_2-s2.0-77951694421en_HK
dc.identifier.hkuros180808-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951694421&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1547en_HK
dc.identifier.epage1554en_HK
dc.identifier.isiWOS:000276994400033-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.erratumdoi:10.1093/ndt/gfq312-
dc.identifier.scopusauthoridLou, T=7004047319en_HK
dc.identifier.scopusauthoridZhang, J=7601342172en_HK
dc.identifier.scopusauthoridGale, DP=22634019700en_HK
dc.identifier.scopusauthoridRees, AJ=7201968937en_HK
dc.identifier.scopusauthoridRhodes, B=24076981400en_HK
dc.identifier.scopusauthoridFeehally, J=7005075936en_HK
dc.identifier.scopusauthoridLi, C=26663041900en_HK
dc.identifier.scopusauthoridLi, Y=8930727500en_HK
dc.identifier.scopusauthoridLi, R=55491291300en_HK
dc.identifier.scopusauthoridHuang, W=10041590500en_HK
dc.identifier.scopusauthoridHu, B=36087575900en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLam, MF=35300050600en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridWang, Y=36088373700en_HK
dc.identifier.scopusauthoridMaxwell, PH=35399996300en_HK

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