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- Publisher Website: 10.1093/carcin/bgp236
- Scopus: eid_2-s2.0-73949094187
- PMID: 19793799
- WOS: WOS:000272684700001
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Article: Role of notch signaling in colorectal cancer
Title | Role of notch signaling in colorectal cancer |
---|---|
Authors | |
Issue Date | 2009 |
Publisher | Oxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/ |
Citation | Carcinogenesis, 2009, v. 30 n. 12, p. 1979-1986 How to Cite? |
Abstract | Notch signaling is an important molecular pathway involved in the determination of cell fate. In recent years, this signaling has been frequently reported to play a critical role in maintaining progenitor/stem cell population as well as a balance between cell proliferation, differentiation and apoptosis. Thus, Notch signaling may be mechanistically involved carcinogenesis. Indeed, many studies have showed that Notch signaling is overexpressed or constitutively activated in many cancers including colorectal cancer (CRC). Consequently, inactivation of Notch signaling may constitute a novel molecular therapy for cancer. CRC is one of the most common malignancies but the current therapeutic approaches for advanced CRC are less efficient. Thus, novel therapeutic approaches are badly needed. In this review article, the authors reviewed the current understanding and research findings of the role of Notch signaling in CRC and discussed the possible Notch-targeting approaches in CRC. © The Author 2009. Published by Oxford University Press. |
Persistent Identifier | http://hdl.handle.net/10722/163289 |
ISSN | 2021 Impact Factor: 4.741 2020 SCImago Journal Rankings: 1.688 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Qiao, L | en_HK |
dc.contributor.author | Wong, BC | en_HK |
dc.date.accessioned | 2012-09-05T05:29:40Z | - |
dc.date.available | 2012-09-05T05:29:40Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Carcinogenesis, 2009, v. 30 n. 12, p. 1979-1986 | en_HK |
dc.identifier.issn | 0143-3334 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163289 | - |
dc.description.abstract | Notch signaling is an important molecular pathway involved in the determination of cell fate. In recent years, this signaling has been frequently reported to play a critical role in maintaining progenitor/stem cell population as well as a balance between cell proliferation, differentiation and apoptosis. Thus, Notch signaling may be mechanistically involved carcinogenesis. Indeed, many studies have showed that Notch signaling is overexpressed or constitutively activated in many cancers including colorectal cancer (CRC). Consequently, inactivation of Notch signaling may constitute a novel molecular therapy for cancer. CRC is one of the most common malignancies but the current therapeutic approaches for advanced CRC are less efficient. Thus, novel therapeutic approaches are badly needed. In this review article, the authors reviewed the current understanding and research findings of the role of Notch signaling in CRC and discussed the possible Notch-targeting approaches in CRC. © The Author 2009. Published by Oxford University Press. | en_HK |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/ | en_HK |
dc.relation.ispartof | Carcinogenesis | en_HK |
dc.title | Role of notch signaling in colorectal cancer | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Qiao, L: lq8688@hotmail.com | en_HK |
dc.identifier.email | Wong, BC: bcywong@hku.hk | en_HK |
dc.identifier.authority | Qiao, L=rp00513 | en_HK |
dc.identifier.authority | Wong, BC=rp00429 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1093/carcin/bgp236 | en_HK |
dc.identifier.pmid | 19793799 | - |
dc.identifier.scopus | eid_2-s2.0-73949094187 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-73949094187&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 30 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 1979 | en_HK |
dc.identifier.epage | 1986 | en_HK |
dc.identifier.isi | WOS:000272684700001 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Qiao, L=7202151719 | en_HK |
dc.identifier.scopusauthorid | Wong, BC=7402023340 | en_HK |
dc.identifier.issnl | 0143-3334 | - |