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Article: Upgrading pacemaker patients with right ventricular apical pacing to right ventricular septal pacing improves left ventricular performance and functional capacity

TitleUpgrading pacemaker patients with right ventricular apical pacing to right ventricular septal pacing improves left ventricular performance and functional capacity
Authors
Issue Date2009
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 2009, v. 20 n. 8, p. 901-905 How to Cite?
AbstractRight Ventricular Septal Pacing Upgrade. Background: Right ventricular (RV) apical pacing results in abnormal left ventricular (LV) electrical and mechanical activation and is associated with an increased risk of developing heart failure. Chronic RV septal pacing has been shown to be superior to RV apical pacing in newly implanted patients. However, whether RV septal pacing can reverse deleterious effects of RV apical pacing remain unclear. Methods: We evaluated the effects of RV septal pacing on LV performance and functional capacity before and at 18 months after device replacement in 12 patients with previously permanent RV apical pacing and in 12 control patients that continued RV apical pacing. All patients underwent radionuclide ventriculography and 6-minute hallwalk (6-MHW) test before replacement (baseline) and at 18 months afterward to determine changes in LV performance and functional capacity, respectively. Results: After RV septal upgraded, there was a significant decrease in paced QRS duration (171.2 ± 3.9 ms to 160.4 ± 3.5 ms, P = 0.0016), increase in LV ejection fraction (55.2 ± 2.6% vs 60.4 ± 2.9%, P = 0.0002), the peak ventricular filling rate (2.60 ± 0.13 s -1 vs 3.01 ± 0.14 s -1, P = 0.046), and 6-MHW (308.2 ± 31.6 m vs 355.5 ± 34.2 m, P = 0.015) at 18 months compared with baseline. No changes in these parameters were observed in the control group (P > 0.05). Conclusion: RV septal pacing upgraded improves LV systolic and diastolic function and functional capacity in patients with previously permanent RV apical pacing. These findings suggest that RV septal pacing can reverse the deleterious effects of RV apical pacing in patients who required permanent ventricular pacing. (J Cardiovasc Electrophysiol, Vol. 20, pp. 901-905, August 2009) © 2009 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/163261
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 1.863
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_US
dc.contributor.authorWong, KKen_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorZhang, XHen_US
dc.contributor.authorHo, WYen_US
dc.contributor.authorLau, CPen_US
dc.date.accessioned2012-09-05T05:29:17Z-
dc.date.available2012-09-05T05:29:17Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 2009, v. 20 n. 8, p. 901-905en_US
dc.identifier.issn1045-3873en_US
dc.identifier.urihttp://hdl.handle.net/10722/163261-
dc.description.abstractRight Ventricular Septal Pacing Upgrade. Background: Right ventricular (RV) apical pacing results in abnormal left ventricular (LV) electrical and mechanical activation and is associated with an increased risk of developing heart failure. Chronic RV septal pacing has been shown to be superior to RV apical pacing in newly implanted patients. However, whether RV septal pacing can reverse deleterious effects of RV apical pacing remain unclear. Methods: We evaluated the effects of RV septal pacing on LV performance and functional capacity before and at 18 months after device replacement in 12 patients with previously permanent RV apical pacing and in 12 control patients that continued RV apical pacing. All patients underwent radionuclide ventriculography and 6-minute hallwalk (6-MHW) test before replacement (baseline) and at 18 months afterward to determine changes in LV performance and functional capacity, respectively. Results: After RV septal upgraded, there was a significant decrease in paced QRS duration (171.2 ± 3.9 ms to 160.4 ± 3.5 ms, P = 0.0016), increase in LV ejection fraction (55.2 ± 2.6% vs 60.4 ± 2.9%, P = 0.0002), the peak ventricular filling rate (2.60 ± 0.13 s -1 vs 3.01 ± 0.14 s -1, P = 0.046), and 6-MHW (308.2 ± 31.6 m vs 355.5 ± 34.2 m, P = 0.015) at 18 months compared with baseline. No changes in these parameters were observed in the control group (P > 0.05). Conclusion: RV septal pacing upgraded improves LV systolic and diastolic function and functional capacity in patients with previously permanent RV apical pacing. These findings suggest that RV septal pacing can reverse the deleterious effects of RV apical pacing in patients who required permanent ventricular pacing. (J Cardiovasc Electrophysiol, Vol. 20, pp. 901-905, August 2009) © 2009 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_US
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCardiac Pacing, Artificial - Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPacemaker, Artificialen_US
dc.subject.meshRadionuclide Ventriculography - Methodsen_US
dc.subject.meshVentricular Dysfunction, Left - Physiopathology - Therapyen_US
dc.subject.meshVentricular Function, Left - Physiologyen_US
dc.subject.meshVentricular Function, Right - Physiologyen_US
dc.subject.meshVentricular Septum - Physiologyen_US
dc.titleUpgrading pacemaker patients with right ventricular apical pacing to right ventricular septal pacing improves left ventricular performance and functional capacityen_US
dc.typeArticleen_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1540-8167.2009.01470.xen_US
dc.identifier.pmid19490265-
dc.identifier.scopuseid_2-s2.0-68149105739en_US
dc.identifier.hkuros158534-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68149105739&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue8en_US
dc.identifier.spage901en_US
dc.identifier.epage905en_US
dc.identifier.isiWOS:000268457600011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US
dc.identifier.scopusauthoridWong, KK=7404758873en_US
dc.identifier.scopusauthoridSiu, CW=7006550690en_US
dc.identifier.scopusauthoridZhang, XH=16425051500en_US
dc.identifier.scopusauthoridHo, WY=25938053100en_US
dc.identifier.scopusauthoridLau, CP=7401968501en_US
dc.identifier.citeulike5430675-

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