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- Publisher Website: 10.1016/j.bone.2009.03.676
- Scopus: eid_2-s2.0-67649651479
- PMID: 19371798
- WOS: WOS:000268206300020
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Article: The - 9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPα and FOXA1 binding is associated with osteoporosis
Title | The - 9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPα and FOXA1 binding is associated with osteoporosis |
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Authors | |
Keywords | Association Osteoporosis Sclerostin |
Issue Date | 2009 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone |
Citation | Bone, 2009, v. 45 n. 2, p. 289-294 How to Cite? |
Abstract | Accumulating evidence shows that genes that cause monogenic diseases also contribute to similar complex disease in the general population. We sought to determine whether the allelic variation in seven monogenic bone disease genes (CLCN7, TCIRGI, SOST, CA2, CSTK, TGFB1 and SLC26A2) contributes to osteoporosis/bone mineral density (BMD) variation in the normal Chinese population. We conducted a gene-wide tag SNP-based association study in 1243 Chinese subjects with low BMD (Z-scores ≤ - 1.28, equivalent to the lowest 10% of the population) and high BMD (Z-score ≥ + 1.0). Twenty-two tag SNPs were selected and genotyped by using the high-throughput Sequenom genotyping platform. Allelic and haplotype association tests were conducted by Haploview and binary logistic regression analyses. The - 9247 polymorphism rs1230399 in the upstream regulatory region of the sclerostin gene showed significant genotypic/allelic associations with spine, femoral neck, trochanter and total hip BMD (P = 0.03-0.004). The T-allele of rs1230399 increased the risk of osteoporosis (OR = 1.52, P = 0.005). Computational analysis showed that rs1230399 is located at the core consensus recognition site of two cooperating transcription factors C/EBPα and FOXA1 that modulate estrogen receptor function. T → C polymorphism abolishes the binding of both C/EBPα and FOXA1 to the sclerostin gene. Our data suggest a mechanistic link between rs1230399 and BMD through estrogen ERα/FOXA1 signaling pathways driven by long-distance enhancers. © 2009 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/163257 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.179 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huang, QY | en_HK |
dc.contributor.author | Li, GHY | en_HK |
dc.contributor.author | Kung, AWC | en_HK |
dc.date.accessioned | 2012-09-05T05:29:13Z | - |
dc.date.available | 2012-09-05T05:29:13Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Bone, 2009, v. 45 n. 2, p. 289-294 | en_HK |
dc.identifier.issn | 8756-3282 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163257 | - |
dc.description.abstract | Accumulating evidence shows that genes that cause monogenic diseases also contribute to similar complex disease in the general population. We sought to determine whether the allelic variation in seven monogenic bone disease genes (CLCN7, TCIRGI, SOST, CA2, CSTK, TGFB1 and SLC26A2) contributes to osteoporosis/bone mineral density (BMD) variation in the normal Chinese population. We conducted a gene-wide tag SNP-based association study in 1243 Chinese subjects with low BMD (Z-scores ≤ - 1.28, equivalent to the lowest 10% of the population) and high BMD (Z-score ≥ + 1.0). Twenty-two tag SNPs were selected and genotyped by using the high-throughput Sequenom genotyping platform. Allelic and haplotype association tests were conducted by Haploview and binary logistic regression analyses. The - 9247 polymorphism rs1230399 in the upstream regulatory region of the sclerostin gene showed significant genotypic/allelic associations with spine, femoral neck, trochanter and total hip BMD (P = 0.03-0.004). The T-allele of rs1230399 increased the risk of osteoporosis (OR = 1.52, P = 0.005). Computational analysis showed that rs1230399 is located at the core consensus recognition site of two cooperating transcription factors C/EBPα and FOXA1 that modulate estrogen receptor function. T → C polymorphism abolishes the binding of both C/EBPα and FOXA1 to the sclerostin gene. Our data suggest a mechanistic link between rs1230399 and BMD through estrogen ERα/FOXA1 signaling pathways driven by long-distance enhancers. © 2009 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone | en_HK |
dc.relation.ispartof | Bone | en_HK |
dc.rights | Bone. Copyright © Elsevier Inc. | - |
dc.subject | Association | en_HK |
dc.subject | Osteoporosis | en_HK |
dc.subject | Sclerostin | en_HK |
dc.subject.mesh | Bone Morphogenetic Proteins - Genetics | en_US |
dc.subject.mesh | Ccaat-Enhancer-Binding Protein-Alpha - Metabolism | en_US |
dc.subject.mesh | Computational Biology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genetic Markers - Genetics | en_US |
dc.subject.mesh | Genetic Predisposition To Disease | en_US |
dc.subject.mesh | Haplotypes | en_US |
dc.subject.mesh | Hepatocyte Nuclear Factor 3-Alpha - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Osteoporosis - Genetics | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide - Genetics | en_US |
dc.subject.mesh | Protein Binding | en_US |
dc.subject.mesh | Regulatory Sequences, Nucleic Acid - Genetics | en_US |
dc.title | The - 9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPα and FOXA1 binding is associated with osteoporosis | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Huang, QY: qyhuang@hotmail.com | en_HK |
dc.identifier.email | Kung, AWC: awckung@hku.hk | en_HK |
dc.identifier.authority | Huang, QY=rp00521 | en_HK |
dc.identifier.authority | Kung, AWC=rp00368 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.bone.2009.03.676 | en_HK |
dc.identifier.pmid | 19371798 | - |
dc.identifier.scopus | eid_2-s2.0-67649651479 | en_HK |
dc.identifier.hkuros | 155801 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67649651479&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 45 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 289 | en_HK |
dc.identifier.epage | 294 | en_HK |
dc.identifier.isi | WOS:000268206300020 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Huang, QY=7403630787 | en_HK |
dc.identifier.scopusauthorid | Li, GHY=35080710200 | en_HK |
dc.identifier.scopusauthorid | Kung, AWC=7102322339 | en_HK |
dc.identifier.issnl | 1873-2763 | - |