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Article: Reflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring

TitleReflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring
Authors
Issue Date2009
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2009, v. 24 n. 6, p. 1113-1118 How to Cite?
AbstractBackground and Aims: To investigate the reflux profile of Chinese gastroesophageal reflux disease (GERD) patients with the aid of combined multichannel intraluminal impedance-pH (MII-pH) monitoring technique. Methods: Consecutive patients presented with GERD symptoms were enrolled to erosive esophagitis (EE) group, non-erosive reflux disease (NERD) group and functional heartburn (FH) group after upper endoscopy, combined MII-pH monitoring and rabeprazole test. Another 20 healthy controls (HC) were recruited. Results: Sixty-four GERD patients (EE:20, NERD:22, FH:22, HC:20) were enrolled. There were more episodes of liquid reflux and proximal reflux in EE and NERD groups than that in FH and HC groups (P < 0.05). Patients in FH and HC groups had higher proportion of mixed reflux (P = 0.000). The percentage of acid reflux in EE and NERD was much higher, while there was a higher percentage of weakly acidic reflux in FH and HC (P = 0.000). No significant difference was found in MII-pH parameters between groups with and without response to rabeprazole test except recumbent percentage time of esophageal pH value below 4 and episodes of proximal reflux. Conclusion: Erosive esophagitis and NERD patients had more liquid and proximal reflux episodes than FH patients and healthy controls. Acid and liquid reflux was predominant in the former two groups, while weakly acidic and mixed reflux was predominant in the latter two groups. © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/163250
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiao, YLen_US
dc.contributor.authorLin, JKen_US
dc.contributor.authorCheung, TKen_US
dc.contributor.authorWong, NYHen_US
dc.contributor.authorHung, IFNen_US
dc.contributor.authorWong, BCYen_US
dc.contributor.authorPeng, Sen_US
dc.contributor.authorWang, AJen_US
dc.contributor.authorChen, MHen_US
dc.date.accessioned2012-09-05T05:29:08Z-
dc.date.available2012-09-05T05:29:08Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2009, v. 24 n. 6, p. 1113-1118en_US
dc.identifier.issn0815-9319en_US
dc.identifier.urihttp://hdl.handle.net/10722/163250-
dc.description.abstractBackground and Aims: To investigate the reflux profile of Chinese gastroesophageal reflux disease (GERD) patients with the aid of combined multichannel intraluminal impedance-pH (MII-pH) monitoring technique. Methods: Consecutive patients presented with GERD symptoms were enrolled to erosive esophagitis (EE) group, non-erosive reflux disease (NERD) group and functional heartburn (FH) group after upper endoscopy, combined MII-pH monitoring and rabeprazole test. Another 20 healthy controls (HC) were recruited. Results: Sixty-four GERD patients (EE:20, NERD:22, FH:22, HC:20) were enrolled. There were more episodes of liquid reflux and proximal reflux in EE and NERD groups than that in FH and HC groups (P < 0.05). Patients in FH and HC groups had higher proportion of mixed reflux (P = 0.000). The percentage of acid reflux in EE and NERD was much higher, while there was a higher percentage of weakly acidic reflux in FH and HC (P = 0.000). No significant difference was found in MII-pH parameters between groups with and without response to rabeprazole test except recumbent percentage time of esophageal pH value below 4 and episodes of proximal reflux. Conclusion: Erosive esophagitis and NERD patients had more liquid and proximal reflux episodes than FH patients and healthy controls. Acid and liquid reflux was predominant in the former two groups, while weakly acidic and mixed reflux was predominant in the latter two groups. © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_US
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_US
dc.subject.mesh2-Pyridinylmethylsulfinylbenzimidazoles - Therapeutic Useen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnti-Ulcer Agents - Therapeutic Useen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshEsophageal Ph Monitoring - Instrumentationen_US
dc.subject.meshEsophagitis - Drug Therapy - Epidemiology - Physiopathologyen_US
dc.subject.meshEsophagoscopyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastroesophageal Reflux - Drug Therapy - Epidemiology - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleReflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoringen_US
dc.typeArticleen_US
dc.identifier.emailHung, IFN:ivanhung@hkucc.hku.hken_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityHung, IFN=rp00508en_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1746.2009.05861.xen_US
dc.identifier.pmid19638089-
dc.identifier.scopuseid_2-s2.0-66549124137en_US
dc.identifier.hkuros179945-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66549124137&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue6en_US
dc.identifier.spage1113en_US
dc.identifier.epage1118en_US
dc.identifier.isiWOS:000266465000032-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridXiao, YL=23500436000en_US
dc.identifier.scopusauthoridLin, JK=8065241700en_US
dc.identifier.scopusauthoridCheung, TK=7103334158en_US
dc.identifier.scopusauthoridWong, NYH=7202836655en_US
dc.identifier.scopusauthoridHung, IFN=7006103457en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.scopusauthoridPeng, S=8454524700en_US
dc.identifier.scopusauthoridWang, AJ=24462861200en_US
dc.identifier.scopusauthoridChen, MH=8642044500en_US
dc.identifier.citeulike4741092-

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