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Article: A patient-reported outcome instrument to assess the impact of oropharyngeal mucositis on health-related quality of life: A longitudinal psychometric evaluation

TitleA patient-reported outcome instrument to assess the impact of oropharyngeal mucositis on health-related quality of life: A longitudinal psychometric evaluation
Authors
Issue Date2009
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htm
Citation
Supportive Care In Cancer, 2009, v. 17 n. 4, p. 389-398 How to Cite?
AbstractGoals of work: An oropharyngeal mucositis (OM)-specific health-related quality of life measure (OMQoL) has been developed to assess the impact of OM from the perspective of patients. The current paper describes the convergent, concurrent, and known-group validities and responsiveness in relation to clinical and health outcomes. Materials and methods: A multicenter approach was used, and 137 patients treated with different cancer therapies completed the OMQoL and the European Organization for Research and Treatment of Cancer Quality of Life questionnaire [EORTC QLQ-C30 (Ch)] twice over a 4-week period or weekly over a 7-week period, along with concurrent measures of OM and its related symptoms. Main results: The OM-related symptom scores correlated highly with the OMQoL, confirming its convergent validity (r∈=∈-0.724 - 0.971, p∈<∈0.01). Moderate correlations between the subscales of the OMQoL and EORTC QLQ-C30 (Ch) were indicative of good concurrent validity (r∈=∈0.450-0.724, p∈<∈0.01). The OMQoL was able to distinguish between patients with different severities of OM (p∈<∈0.01) and types of cancer therapy (p∈<∈0.01), providing evidence of good known-group validity. The changes in effects sizes corresponding to changes in OM curves indicate that the OMQoL is responsive to changes in OM status. Conclusions: These findings suggest that the OMQoL has very good psychometric properties and can be used as a health-related quality of life assessment for cancer patients with OM. Much work is still needed in strengthening the psychometric qualities and interpretability of the OMQoL by demonstrating its ability to detect outcome changes over time. © 2008 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/163235
ISSN
2015 Impact Factor: 2.535
2015 SCImago Journal Rankings: 1.267
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, KKFen_US
dc.contributor.authorLeung, SFen_US
dc.contributor.authorLiang, RHSen_US
dc.contributor.authorTai, JWMen_US
dc.contributor.authorYeung, RMWen_US
dc.contributor.authorThompson, DRen_US
dc.date.accessioned2012-09-05T05:29:02Z-
dc.date.available2012-09-05T05:29:02Z-
dc.date.issued2009en_US
dc.identifier.citationSupportive Care In Cancer, 2009, v. 17 n. 4, p. 389-398en_US
dc.identifier.issn0941-4355en_US
dc.identifier.urihttp://hdl.handle.net/10722/163235-
dc.description.abstractGoals of work: An oropharyngeal mucositis (OM)-specific health-related quality of life measure (OMQoL) has been developed to assess the impact of OM from the perspective of patients. The current paper describes the convergent, concurrent, and known-group validities and responsiveness in relation to clinical and health outcomes. Materials and methods: A multicenter approach was used, and 137 patients treated with different cancer therapies completed the OMQoL and the European Organization for Research and Treatment of Cancer Quality of Life questionnaire [EORTC QLQ-C30 (Ch)] twice over a 4-week period or weekly over a 7-week period, along with concurrent measures of OM and its related symptoms. Main results: The OM-related symptom scores correlated highly with the OMQoL, confirming its convergent validity (r∈=∈-0.724 - 0.971, p∈<∈0.01). Moderate correlations between the subscales of the OMQoL and EORTC QLQ-C30 (Ch) were indicative of good concurrent validity (r∈=∈0.450-0.724, p∈<∈0.01). The OMQoL was able to distinguish between patients with different severities of OM (p∈<∈0.01) and types of cancer therapy (p∈<∈0.01), providing evidence of good known-group validity. The changes in effects sizes corresponding to changes in OM curves indicate that the OMQoL is responsive to changes in OM status. Conclusions: These findings suggest that the OMQoL has very good psychometric properties and can be used as a health-related quality of life assessment for cancer patients with OM. Much work is still needed in strengthening the psychometric qualities and interpretability of the OMQoL by demonstrating its ability to detect outcome changes over time. © 2008 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htmen_US
dc.relation.ispartofSupportive Care in Canceren_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMucositis - Etiology - Physiopathology - Psychologyen_US
dc.subject.meshNeoplasms - Complications - Therapyen_US
dc.subject.meshPharyngeal Diseases - Etiology - Physiopathology - Psychologyen_US
dc.subject.meshPsychometricsen_US
dc.subject.meshQuality Of Lifeen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshYoung Adulten_US
dc.titleA patient-reported outcome instrument to assess the impact of oropharyngeal mucositis on health-related quality of life: A longitudinal psychometric evaluationen_US
dc.typeArticleen_US
dc.identifier.emailLiang, RHS:rliang@hku.hken_US
dc.identifier.authorityLiang, RHS=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00520-008-0485-2en_US
dc.identifier.pmid18677517-
dc.identifier.scopuseid_2-s2.0-62449333560en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62449333560&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.spage389en_US
dc.identifier.epage398en_US
dc.identifier.isiWOS:000264183100009-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridCheng, KKF=27172284100en_US
dc.identifier.scopusauthoridLeung, SF=22955953000en_US
dc.identifier.scopusauthoridLiang, RHS=26643224900en_US
dc.identifier.scopusauthoridTai, JWM=7101993154en_US
dc.identifier.scopusauthoridYeung, RMW=7102833329en_US
dc.identifier.scopusauthoridThompson, DR=7404935331en_US

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