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Article: Long-term follow-up of ulcerative colitis in the Chinese population
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TitleLong-term follow-up of ulcerative colitis in the Chinese population
 
AuthorsChow, DKL1
Leong, RWL2
Tsoi, KKF1
Ng, SSM1
Leung, WK1
Wu, JCY1
Wong, VWS1
Chan, FKL1
Sung, JJY1
 
Issue Date2009
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
 
CitationAmerican Journal Of Gastroenterology, 2009, v. 104 n. 3, p. 647-654 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajg.2008.74
 
AbstractOBJECTIVES: The incidence of ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. We set out determine the incidence, prevalence, and survival rate of UC in the Chinese population and phenotypic stability by longitudinal follow-up. METHODS: A cohort of Chinese UC patients were followed up in a tertiary referral center in Hong Kong between 1985 and 2006. Clinical data were prospectively collected since 2001. Population statistics were obtained from the Census and Statistics Department of Hong Kong for the calculation of age-specific incidence, prevalence, and survival. The disease phenotypes at diagnosis and upon follow-up were documented. RESULTS: A total of 172 patients (51.7% men) with a median age at diagnosis of 37.0 years (range: 12.0-85.0) were included. The cohort was observed for a total of 1,393 person-years with a median follow-up duration of 7.0 years (range: 0.5-22.0). The age-standardized incidence and prevalence rates of UC per 100,000 were 2.1 (95% confidence interval, CI: 1.1-3.7) and 26.5 (95% CI: 22.6-30.9), respectively, in 2006. The 10-year cumulative rate of proximal extension was 23.8%. Only one patient developed colorectal cancer during the observation period. The cumulative colectomy rates were 2.4% and 7.6% at 1 and 10 years of follow-up. Overall survival was similar to that expected (P=0.07). CONCLUSIONS: The incidence of UC has increased sixfold in the past two decades in Hong Kong. The complication, colorectal cancer, and colectomy rates are low in Chinese patients but increase with duration of illness. © 2009 by the American College of Gastroenterology.
 
ISSN0002-9270
2012 Impact Factor: 7.553
2012 SCImago Journal Rankings: 2.574
 
DOIhttp://dx.doi.org/10.1038/ajg.2008.74
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChow, DKL
 
dc.contributor.authorLeong, RWL
 
dc.contributor.authorTsoi, KKF
 
dc.contributor.authorNg, SSM
 
dc.contributor.authorLeung, WK
 
dc.contributor.authorWu, JCY
 
dc.contributor.authorWong, VWS
 
dc.contributor.authorChan, FKL
 
dc.contributor.authorSung, JJY
 
dc.date.accessioned2012-09-05T05:29:01Z
 
dc.date.available2012-09-05T05:29:01Z
 
dc.date.issued2009
 
dc.description.abstractOBJECTIVES: The incidence of ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. We set out determine the incidence, prevalence, and survival rate of UC in the Chinese population and phenotypic stability by longitudinal follow-up. METHODS: A cohort of Chinese UC patients were followed up in a tertiary referral center in Hong Kong between 1985 and 2006. Clinical data were prospectively collected since 2001. Population statistics were obtained from the Census and Statistics Department of Hong Kong for the calculation of age-specific incidence, prevalence, and survival. The disease phenotypes at diagnosis and upon follow-up were documented. RESULTS: A total of 172 patients (51.7% men) with a median age at diagnosis of 37.0 years (range: 12.0-85.0) were included. The cohort was observed for a total of 1,393 person-years with a median follow-up duration of 7.0 years (range: 0.5-22.0). The age-standardized incidence and prevalence rates of UC per 100,000 were 2.1 (95% confidence interval, CI: 1.1-3.7) and 26.5 (95% CI: 22.6-30.9), respectively, in 2006. The 10-year cumulative rate of proximal extension was 23.8%. Only one patient developed colorectal cancer during the observation period. The cumulative colectomy rates were 2.4% and 7.6% at 1 and 10 years of follow-up. Overall survival was similar to that expected (P=0.07). CONCLUSIONS: The incidence of UC has increased sixfold in the past two decades in Hong Kong. The complication, colorectal cancer, and colectomy rates are low in Chinese patients but increase with duration of illness. © 2009 by the American College of Gastroenterology.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Gastroenterology, 2009, v. 104 n. 3, p. 647-654 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajg.2008.74
 
dc.identifier.doihttp://dx.doi.org/10.1038/ajg.2008.74
 
dc.identifier.epage654
 
dc.identifier.issn0002-9270
2012 Impact Factor: 7.553
2012 SCImago Journal Rankings: 2.574
 
dc.identifier.issue3
 
dc.identifier.pmid19262521
 
dc.identifier.scopuseid_2-s2.0-61949101620
 
dc.identifier.spage647
 
dc.identifier.urihttp://hdl.handle.net/10722/163234
 
dc.identifier.volume104
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Gastroenterology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshAsian Continental Ancestry Group
 
dc.subject.meshColitis, Ulcerative - Complications - Epidemiology - Pathology - Surgery
 
dc.subject.meshFollow-Up Studies
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshIncidence
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPrevalence
 
dc.subject.meshYoung Adult
 
dc.titleLong-term follow-up of ulcerative colitis in the Chinese population
 
dc.typeArticle
 
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<contributor.author>Ng, SSM</contributor.author>
<contributor.author>Leung, WK</contributor.author>
<contributor.author>Wu, JCY</contributor.author>
<contributor.author>Wong, VWS</contributor.author>
<contributor.author>Chan, FKL</contributor.author>
<contributor.author>Sung, JJY</contributor.author>
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<description.abstract>OBJECTIVES: The incidence of ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. We set out determine the incidence, prevalence, and survival rate of UC in the Chinese population and phenotypic stability by longitudinal follow-up. METHODS: A cohort of Chinese UC patients were followed up in a tertiary referral center in Hong Kong between 1985 and 2006. Clinical data were prospectively collected since 2001. Population statistics were obtained from the Census and Statistics Department of Hong Kong for the calculation of age-specific incidence, prevalence, and survival. The disease phenotypes at diagnosis and upon follow-up were documented. RESULTS: A total of 172 patients (51.7% men) with a median age at diagnosis of 37.0 years (range: 12.0-85.0) were included. The cohort was observed for a total of 1,393 person-years with a median follow-up duration of 7.0 years (range: 0.5-22.0). The age-standardized incidence and prevalence rates of UC per 100,000 were 2.1 (95% confidence interval, CI: 1.1-3.7) and 26.5 (95% CI: 22.6-30.9), respectively, in 2006. The 10-year cumulative rate of proximal extension was 23.8%. Only one patient developed colorectal cancer during the observation period. The cumulative colectomy rates were 2.4% and 7.6% at 1 and 10 years of follow-up. Overall survival was similar to that expected (P=0.07). CONCLUSIONS: The incidence of UC has increased sixfold in the past two decades in Hong Kong. The complication, colorectal cancer, and colectomy rates are low in Chinese patients but increase with duration of illness. &#169; 2009 by the American College of Gastroenterology.</description.abstract>
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Author Affiliations
  1. Prince of Wales Hospital Hong Kong
  2. University of New South Wales