Article: Long-term follow-up of ulcerative colitis in the Chinese population

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TitleLong-term follow-up of ulcerative colitis in the Chinese population
AuthorsChow, DKL1
Leong, RWL2
Tsoi, KKF1
Ng, SSM1
Leung, WK1
Wu, JCY1
Wong, VWS1
Chan, FKL1
Sung, JJY1
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
CitationAmerican Journal Of Gastroenterology, 2009, v. 104 n. 3, p. 647-654 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajg.2008.74
AbstractOBJECTIVES: The incidence of ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. We set out determine the incidence, prevalence, and survival rate of UC in the Chinese population and phenotypic stability by longitudinal follow-up. METHODS: A cohort of Chinese UC patients were followed up in a tertiary referral center in Hong Kong between 1985 and 2006. Clinical data were prospectively collected since 2001. Population statistics were obtained from the Census and Statistics Department of Hong Kong for the calculation of age-specific incidence, prevalence, and survival. The disease phenotypes at diagnosis and upon follow-up were documented. RESULTS: A total of 172 patients (51.7% men) with a median age at diagnosis of 37.0 years (range: 12.0-85.0) were included. The cohort was observed for a total of 1,393 person-years with a median follow-up duration of 7.0 years (range: 0.5-22.0). The age-standardized incidence and prevalence rates of UC per 100,000 were 2.1 (95% confidence interval, CI: 1.1-3.7) and 26.5 (95% CI: 22.6-30.9), respectively, in 2006. The 10-year cumulative rate of proximal extension was 23.8%. Only one patient developed colorectal cancer during the observation period. The cumulative colectomy rates were 2.4% and 7.6% at 1 and 10 years of follow-up. Overall survival was similar to that expected (P=0.07). CONCLUSIONS: The incidence of UC has increased sixfold in the past two decades in Hong Kong. The complication, colorectal cancer, and colectomy rates are low in Chinese patients but increase with duration of illness. © 2009 by the American College of Gastroenterology.
ISSN0002-9270
2011 Impact Factor: 7.282
2011 SCImago Journal Rankings: 0.573
DOIhttp://dx.doi.org/10.1038/ajg.2008.74
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChow, DKL
dc.contributor.authorLeong, RWL
dc.contributor.authorTsoi, KKF
dc.contributor.authorNg, SSM
dc.contributor.authorLeung, WK
dc.contributor.authorWu, JCY
dc.contributor.authorWong, VWS
dc.contributor.authorChan, FKL
dc.contributor.authorSung, JJY
dc.date.accessioned2012-09-05T05:29:01Z
dc.date.available2012-09-05T05:29:01Z
dc.date.issued2009
dc.description.abstractOBJECTIVES: The incidence of ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. We set out determine the incidence, prevalence, and survival rate of UC in the Chinese population and phenotypic stability by longitudinal follow-up. METHODS: A cohort of Chinese UC patients were followed up in a tertiary referral center in Hong Kong between 1985 and 2006. Clinical data were prospectively collected since 2001. Population statistics were obtained from the Census and Statistics Department of Hong Kong for the calculation of age-specific incidence, prevalence, and survival. The disease phenotypes at diagnosis and upon follow-up were documented. RESULTS: A total of 172 patients (51.7% men) with a median age at diagnosis of 37.0 years (range: 12.0-85.0) were included. The cohort was observed for a total of 1,393 person-years with a median follow-up duration of 7.0 years (range: 0.5-22.0). The age-standardized incidence and prevalence rates of UC per 100,000 were 2.1 (95% confidence interval, CI: 1.1-3.7) and 26.5 (95% CI: 22.6-30.9), respectively, in 2006. The 10-year cumulative rate of proximal extension was 23.8%. Only one patient developed colorectal cancer during the observation period. The cumulative colectomy rates were 2.4% and 7.6% at 1 and 10 years of follow-up. Overall survival was similar to that expected (P=0.07). CONCLUSIONS: The incidence of UC has increased sixfold in the past two decades in Hong Kong. The complication, colorectal cancer, and colectomy rates are low in Chinese patients but increase with duration of illness. © 2009 by the American College of Gastroenterology.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAmerican Journal Of Gastroenterology, 2009, v. 104 n. 3, p. 647-654 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajg.2008.74
dc.identifier.doihttp://dx.doi.org/10.1038/ajg.2008.74
dc.identifier.epage654
dc.identifier.issn0002-9270
2011 Impact Factor: 7.282
2011 SCImago Journal Rankings: 0.573
dc.identifier.issue3
dc.identifier.pmid19262521
dc.identifier.scopuseid_2-s2.0-61949101620
dc.identifier.spage647
dc.identifier.urihttp://hdl.handle.net/10722/163234
dc.identifier.volume104
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
dc.publisher.placeUnited States
dc.relation.ispartofAmerican Journal of Gastroenterology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 And Over
dc.subject.meshAsian Continental Ancestry Group
dc.subject.meshColitis, Ulcerative - Complications - Epidemiology - Pathology - Surgery
dc.subject.meshFollow-Up Studies
dc.subject.meshHong Kong - Epidemiology
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrevalence
dc.subject.meshYoung Adult
dc.titleLong-term follow-up of ulcerative colitis in the Chinese population
dc.typeArticle
Author Affiliations
  1. Prince of Wales Hospital Hong Kong
  2. University of New South Wales