File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Gender differences on brachial flow-mediated dilation and carotid intima-media thickness for prediction of spontaneous cardiovascular events.
  • Basic View
  • Metadata View
  • XML View
TitleGender differences on brachial flow-mediated dilation and carotid intima-media thickness for prediction of spontaneous cardiovascular events.
 
AuthorsHu, R2
Wang, WQ2
Lau, CP1
Tse, HF1
 
Issue Date2008
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.clinicalcardiology.org
 
CitationClinical Cardiology, 2008, v. 31 n. 11, p. 525-530 [How to Cite?]
DOI: http://dx.doi.org/10.1002/clc.20314
 
AbstractBACKGROUND: Impaired brachial flow-mediated dilation (FMD) and increased carotid intima-media thickness (IMT) are associated with increased risk of cardiovascular events. METHODS: We measured brachial FMD and a mean of 12 sites maximum carotid IMT (mmIMT) in 279 patients (mean age 62 +/- 12 y; 163 men) admitted for coronary angiography due to chest pain. HYPOTHESIS: There are gender differences in the predictive values of FMD and IMT for cardiovascular events. RESULTS: Univariable analysis showed that impaired FMD (p < 0.001), but not increased mmIMT (p = 0.056), significantly predicted spontaneous cardiovascular events. After adjusting for the extent of coronary artery disease (CAD) and other clinical variables, age (heart rate [HR] 1.05, 95% confidence interval [CI]: 1.01-1.09, p = 0.017) and FMD (HR 0.85, 95% CI: 0.75-0.97, p = 0.012) were independent predictors for cardiovascular events. A total of 148 (53%) patients had CAD (> or =50% diameter stenosis). Over a median follow-up of 16 mo, 36 (12.9%) patients experienced spontaneous cardiovascular events (cardiovascular death, stroke, acute myocardial infarction [MI], unstable angina pectoris, and congestive heart failure [HF]). Women were more likely than men to develop cardiovascular events in patients without significant CAD (11.9% versus 1.6%, odds ratio [OR] = 8.54, p = 0.033), but not in those patients with CAD (20.4 % versus 17.2%, OR = 1.24, p = 0.66). Moreover, women accounted for 8 (88.9%) events in non-CAD patients. Furthermore, impaired FMD predicted the occurrence of cardiovascular events in both men and women (p < 0.05). CONCLUSION: Brachial FMD, rather than carotid IMT, was an independent predictor for cardiovascular events after adjusting for the extent of CAD. Moreover, impaired brachial endothelial function in women without significant CAD was associated with an increased risk of spontaneous cardiovascular events. Copyright 2008 Wiley Periodicals, Inc.
 
ISSN0160-9289
2013 Impact Factor: 2.225
2013 SCImago Journal Rankings: 1.003
 
DOIhttp://dx.doi.org/10.1002/clc.20314
 
DC FieldValue
dc.contributor.authorHu, R
 
dc.contributor.authorWang, WQ
 
dc.contributor.authorLau, CP
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2012-09-05T05:29:00Z
 
dc.date.available2012-09-05T05:29:00Z
 
dc.date.issued2008
 
dc.description.abstractBACKGROUND: Impaired brachial flow-mediated dilation (FMD) and increased carotid intima-media thickness (IMT) are associated with increased risk of cardiovascular events. METHODS: We measured brachial FMD and a mean of 12 sites maximum carotid IMT (mmIMT) in 279 patients (mean age 62 +/- 12 y; 163 men) admitted for coronary angiography due to chest pain. HYPOTHESIS: There are gender differences in the predictive values of FMD and IMT for cardiovascular events. RESULTS: Univariable analysis showed that impaired FMD (p < 0.001), but not increased mmIMT (p = 0.056), significantly predicted spontaneous cardiovascular events. After adjusting for the extent of coronary artery disease (CAD) and other clinical variables, age (heart rate [HR] 1.05, 95% confidence interval [CI]: 1.01-1.09, p = 0.017) and FMD (HR 0.85, 95% CI: 0.75-0.97, p = 0.012) were independent predictors for cardiovascular events. A total of 148 (53%) patients had CAD (> or =50% diameter stenosis). Over a median follow-up of 16 mo, 36 (12.9%) patients experienced spontaneous cardiovascular events (cardiovascular death, stroke, acute myocardial infarction [MI], unstable angina pectoris, and congestive heart failure [HF]). Women were more likely than men to develop cardiovascular events in patients without significant CAD (11.9% versus 1.6%, odds ratio [OR] = 8.54, p = 0.033), but not in those patients with CAD (20.4 % versus 17.2%, OR = 1.24, p = 0.66). Moreover, women accounted for 8 (88.9%) events in non-CAD patients. Furthermore, impaired FMD predicted the occurrence of cardiovascular events in both men and women (p < 0.05). CONCLUSION: Brachial FMD, rather than carotid IMT, was an independent predictor for cardiovascular events after adjusting for the extent of CAD. Moreover, impaired brachial endothelial function in women without significant CAD was associated with an increased risk of spontaneous cardiovascular events. Copyright 2008 Wiley Periodicals, Inc.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationClinical Cardiology, 2008, v. 31 n. 11, p. 525-530 [How to Cite?]
DOI: http://dx.doi.org/10.1002/clc.20314
 
dc.identifier.doihttp://dx.doi.org/10.1002/clc.20314
 
dc.identifier.epage530
 
dc.identifier.hkuros140844
 
dc.identifier.issn0160-9289
2013 Impact Factor: 2.225
2013 SCImago Journal Rankings: 1.003
 
dc.identifier.issue11
 
dc.identifier.pmid19006116
 
dc.identifier.scopuseid_2-s2.0-60849136650
 
dc.identifier.spage525
 
dc.identifier.urihttp://hdl.handle.net/10722/163231
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.clinicalcardiology.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical cardiology
 
dc.subject.meshAge Factors
 
dc.subject.meshBrachial Artery
 
dc.subject.meshCardiovascular Diseases - Pathology - Physiopathology
 
dc.subject.meshCarotid Arteries - Pathology
 
dc.subject.meshConfidence Intervals
 
dc.subject.meshCoronary Artery Disease - Pathology - Physiopathology
 
dc.subject.meshEndothelium, Vascular - Pathology - Physiopathology
 
dc.subject.meshFemale
 
dc.subject.meshHeart Rate
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPrognosis
 
dc.subject.meshProspective Studies
 
dc.subject.meshRisk Factors
 
dc.subject.meshSeverity Of Illness Index
 
dc.subject.meshSex Factors
 
dc.subject.meshTunica Intima - Pathology
 
dc.subject.meshTunica Media - Pathology
 
dc.subject.meshVasodilation
 
dc.titleGender differences on brachial flow-mediated dilation and carotid intima-media thickness for prediction of spontaneous cardiovascular events.
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Hu, R</contributor.author>
<contributor.author>Wang, WQ</contributor.author>
<contributor.author>Lau, CP</contributor.author>
<contributor.author>Tse, HF</contributor.author>
<date.accessioned>2012-09-05T05:29:00Z</date.accessioned>
<date.available>2012-09-05T05:29:00Z</date.available>
<date.issued>2008</date.issued>
<identifier.citation>Clinical Cardiology, 2008, v. 31 n. 11, p. 525-530</identifier.citation>
<identifier.issn>0160-9289</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/163231</identifier.uri>
<description.abstract>BACKGROUND: Impaired brachial flow-mediated dilation (FMD) and increased carotid intima-media thickness (IMT) are associated with increased risk of cardiovascular events. METHODS: We measured brachial FMD and a mean of 12 sites maximum carotid IMT (mmIMT) in 279 patients (mean age 62 +/- 12 y; 163 men) admitted for coronary angiography due to chest pain. HYPOTHESIS: There are gender differences in the predictive values of FMD and IMT for cardiovascular events. RESULTS: Univariable analysis showed that impaired FMD (p &lt; 0.001), but not increased mmIMT (p = 0.056), significantly predicted spontaneous cardiovascular events. After adjusting for the extent of coronary artery disease (CAD) and other clinical variables, age (heart rate [HR] 1.05, 95% confidence interval [CI]: 1.01-1.09, p = 0.017) and FMD (HR 0.85, 95% CI: 0.75-0.97, p = 0.012) were independent predictors for cardiovascular events. A total of 148 (53%) patients had CAD (&gt; or =50% diameter stenosis). Over a median follow-up of 16 mo, 36 (12.9%) patients experienced spontaneous cardiovascular events (cardiovascular death, stroke, acute myocardial infarction [MI], unstable angina pectoris, and congestive heart failure [HF]). Women were more likely than men to develop cardiovascular events in patients without significant CAD (11.9% versus 1.6%, odds ratio [OR] = 8.54, p = 0.033), but not in those patients with CAD (20.4 % versus 17.2%, OR = 1.24, p = 0.66). Moreover, women accounted for 8 (88.9%) events in non-CAD patients. Furthermore, impaired FMD predicted the occurrence of cardiovascular events in both men and women (p &lt; 0.05). CONCLUSION: Brachial FMD, rather than carotid IMT, was an independent predictor for cardiovascular events after adjusting for the extent of CAD. Moreover, impaired brachial endothelial function in women without significant CAD was associated with an increased risk of spontaneous cardiovascular events. Copyright 2008 Wiley Periodicals, Inc.</description.abstract>
<language>eng</language>
<publisher>John Wiley &amp; Sons, Inc. The Journal&apos;s web site is located at http://www.clinicalcardiology.org</publisher>
<relation.ispartof>Clinical cardiology</relation.ispartof>
<subject.mesh>Age Factors</subject.mesh>
<subject.mesh>Brachial Artery</subject.mesh>
<subject.mesh>Cardiovascular Diseases - Pathology - Physiopathology</subject.mesh>
<subject.mesh>Carotid Arteries - Pathology</subject.mesh>
<subject.mesh>Confidence Intervals</subject.mesh>
<subject.mesh>Coronary Artery Disease - Pathology - Physiopathology</subject.mesh>
<subject.mesh>Endothelium, Vascular - Pathology - Physiopathology</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Heart Rate</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Prognosis</subject.mesh>
<subject.mesh>Prospective Studies</subject.mesh>
<subject.mesh>Risk Factors</subject.mesh>
<subject.mesh>Severity Of Illness Index</subject.mesh>
<subject.mesh>Sex Factors</subject.mesh>
<subject.mesh>Tunica Intima - Pathology</subject.mesh>
<subject.mesh>Tunica Media - Pathology</subject.mesh>
<subject.mesh>Vasodilation</subject.mesh>
<title>Gender differences on brachial flow-mediated dilation and carotid intima-media thickness for prediction of spontaneous cardiovascular events.</title>
<type>Article</type>
<description.nature>Link_to_OA_fulltext</description.nature>
<identifier.doi>10.1002/clc.20314</identifier.doi>
<identifier.pmid>19006116</identifier.pmid>
<identifier.scopus>eid_2-s2.0-60849136650</identifier.scopus>
<identifier.hkuros>140844</identifier.hkuros>
<identifier.volume>31</identifier.volume>
<identifier.issue>11</identifier.issue>
<identifier.spage>525</identifier.spage>
<identifier.epage>530</identifier.epage>
<publisher.place>United States</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/163231/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Fudan University