Article: Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression

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TitleRosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression
AuthorsChen, BL1
Yu, J2
Zeng, ZR1
Chu, WK2
Wong, CYP2
Cheng, YY2
Sung, JJY2
Hu, PJ1
Leung, WK2
Issue Date2008
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
CitationOncology Reports, 2008, v. 20 n. 5, p. 1093-1097 [How to Cite?]
DOI: http://dx.doi.org/10.3892/or_00000114
AbstractOur previous study demonstrated that PPARγ ligand rosiglitazone prevents gastric carcinogenesis in rats induced by chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this study, we attempted to identify novel anticancer mechanisms of rosiglitazone. By examining the gene expression profiles of MNNG-induced and rosiglitazonetreated gastric cancer with Uniset Rat I Bioarray microarray, we identified a gene that showed prominent responses in the rosiglitazone-treated group. The hypertension-related, calcium-regulated gene (HCaRG) was significantly upregulated in rat gastric carcinoma of the rosiglitazone-treated group when compared with the MNNG group. We further examined HCaRG expression in human gastric cancer and found that the expression of HCaRG was down-regulated in human gastric cancerous tissue. Rosiglitazone markedly induced the expression of HCaRG in the AGS cell line. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.
ISSN1021-335X
2011 Impact Factor: 1.835
2011 SCImago Journal Rankings: 0.196
DOIhttp://dx.doi.org/10.3892/or_00000114
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChen, BL
dc.contributor.authorYu, J
dc.contributor.authorZeng, ZR
dc.contributor.authorChu, WK
dc.contributor.authorWong, CYP
dc.contributor.authorCheng, YY
dc.contributor.authorSung, JJY
dc.contributor.authorHu, PJ
dc.contributor.authorLeung, WK
dc.date.accessioned2012-09-05T05:28:52Z
dc.date.available2012-09-05T05:28:52Z
dc.date.issued2008
dc.description.abstractOur previous study demonstrated that PPARγ ligand rosiglitazone prevents gastric carcinogenesis in rats induced by chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this study, we attempted to identify novel anticancer mechanisms of rosiglitazone. By examining the gene expression profiles of MNNG-induced and rosiglitazonetreated gastric cancer with Uniset Rat I Bioarray microarray, we identified a gene that showed prominent responses in the rosiglitazone-treated group. The hypertension-related, calcium-regulated gene (HCaRG) was significantly upregulated in rat gastric carcinoma of the rosiglitazone-treated group when compared with the MNNG group. We further examined HCaRG expression in human gastric cancer and found that the expression of HCaRG was down-regulated in human gastric cancerous tissue. Rosiglitazone markedly induced the expression of HCaRG in the AGS cell line. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationOncology Reports, 2008, v. 20 n. 5, p. 1093-1097 [How to Cite?]
DOI: http://dx.doi.org/10.3892/or_00000114
dc.identifier.doihttp://dx.doi.org/10.3892/or_00000114
dc.identifier.epage1097
dc.identifier.issn1021-335X
2011 Impact Factor: 1.835
2011 SCImago Journal Rankings: 0.196
dc.identifier.issue5
dc.identifier.pmid18949406
dc.identifier.scopuseid_2-s2.0-58149329042
dc.identifier.spage1093
dc.identifier.urihttp://hdl.handle.net/10722/163220
dc.identifier.volume20
dc.languageeng
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
dc.publisher.placeGreece
dc.relation.ispartofOncology Reports
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents - Pharmacology
dc.subject.meshCell Line, Tumor
dc.subject.meshDown-Regulation
dc.subject.meshGene Expression
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMethylnitronitrosoguanidine - Toxicity
dc.subject.meshNuclear Proteins - Biosynthesis - Drug Effects - Genetics
dc.subject.meshOligonucleotide Array Sequence Analysis
dc.subject.meshRats
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshStomach Neoplasms - Drug Therapy - Metabolism
dc.subject.meshThiazolidinediones - Pharmacology
dc.subject.meshUp-Regulation
dc.titleRosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression
dc.typeArticle
Author Affiliations
  1. Sun Yat-Sen University
  2. Chinese University of Hong Kong