File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia

Titlet(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia
Authors
Issue Date2008
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2008, v. 39 n. 11, p. 1702-1707 How to Cite?
AbstractA Chinese girl presented with generalized papular rash and monocytic leukemia 19 days after birth. Cytogenetic analysis showed t(8;16)(p11.2;p13.3) as the sole chromosomal abnormality. Spontaneous regression of the leukemia was observed after 2 months, although the t(8;16) translocation persisted cytogenetically. This was followed 7 months later by the development of acute myeloid leukemia with maturation and cytogenetic evolution with extra chromosomes 4 and 8. Molecular study showed that the reciprocal MYST3 and CREBBP gene fusion characteristic of t(8;16) translocation persisted throughout the clinical course, even during spontaneous regression of the neonatal leukemia, and after chemotherapy-induced remission of the subsequent acute myeloid leukemia. The genetic lesion only became undetectable at the molecular level at the age of 20 months. The possible role of MYST3 and CREBBP gene fusion in the pathogenesis of the leukemia is discussed. © 2008.
Persistent Identifierhttp://hdl.handle.net/10722/163208
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_US
dc.contributor.authorYuen, HLen_US
dc.contributor.authorSiu, LLPen_US
dc.contributor.authorPang, Aen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:28:46Z-
dc.date.available2012-09-05T05:28:46Z-
dc.date.issued2008en_US
dc.identifier.citationHuman Pathology, 2008, v. 39 n. 11, p. 1702-1707en_US
dc.identifier.issn0046-8177en_US
dc.identifier.urihttp://hdl.handle.net/10722/163208-
dc.description.abstractA Chinese girl presented with generalized papular rash and monocytic leukemia 19 days after birth. Cytogenetic analysis showed t(8;16)(p11.2;p13.3) as the sole chromosomal abnormality. Spontaneous regression of the leukemia was observed after 2 months, although the t(8;16) translocation persisted cytogenetically. This was followed 7 months later by the development of acute myeloid leukemia with maturation and cytogenetic evolution with extra chromosomes 4 and 8. Molecular study showed that the reciprocal MYST3 and CREBBP gene fusion characteristic of t(8;16) translocation persisted throughout the clinical course, even during spontaneous regression of the neonatal leukemia, and after chemotherapy-induced remission of the subsequent acute myeloid leukemia. The genetic lesion only became undetectable at the molecular level at the age of 20 months. The possible role of MYST3 and CREBBP gene fusion in the pathogenesis of the leukemia is discussed. © 2008.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_US
dc.relation.ispartofHuman Pathologyen_US
dc.subject.meshCreb-Binding Protein - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 8en_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Fusionen_US
dc.subject.meshHistone Acetyltransferases - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLeukemia, Monocytic, Acute - Geneticsen_US
dc.subject.meshLeukemia, Myeloid, Acute - Drug Therapy - Geneticsen_US
dc.subject.meshRemission, Spontaneousen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titlet(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemiaen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.humpath.2008.02.018en_US
dc.identifier.pmid18657848en_US
dc.identifier.scopuseid_2-s2.0-53849108764en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53849108764&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue11en_US
dc.identifier.spage1702en_US
dc.identifier.epage1707en_US
dc.identifier.isiWOS:000260455300018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, KF=37096553800en_US
dc.identifier.scopusauthoridYuen, HL=7103253677en_US
dc.identifier.scopusauthoridSiu, LLP=35574705900en_US
dc.identifier.scopusauthoridPang, A=7007044165en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats