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Article: Expression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis

TitleExpression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis
Authors
Issue Date2008
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCL
Citation
Oncology, 2008, v. 73 n. 5-6, p. 357-365 How to Cite?
AbstractIn this paper, we investigated Cdx2 and claudin-2 expression in pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy to determine the correlation between the expressions of these 2 genes during gastric carcinogenesis by immunochemical ABC technique. Altogether, we analyzed 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples. Our results indicated that the percentage of Cdx2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 90.83% (99/109) for intestinal-type metaplasia, 51.61% (48/93) for dysplasia and 61.54% (32/52) for gastric intestinal-type adenocarcinoma, primarily expressed in the cell nucleus and partly in the cytoplasm (p < 0.05); interestingly, the percentage for the intestine-type metaplasia was markedly high. The percentage of claudin-2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 0% (0/109) for intestinal-type metaplasia, 35.48% (33/93) for dysplasia and 71.15% (37/52) for gastric intestinal-type adenocarcinoma, primarily in the cell membrane and gradually increased in the multistage process of gastric carcinogenesis (p < 0.05). Significant correlations were found between claudin-2 and Cdx2 protein expression in dysplasia and intestine-type adenocarcinoma (r = 0.112, p < 0.05). Thus, there may be a correlation between the expression of claudin-2 and Cdx2 in stages of dysplasia and cancer. Copyright © 2008 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/163178
ISSN
2015 Impact Factor: 2.152
2015 SCImago Journal Rankings: 0.920
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXin, Sen_US
dc.contributor.authorHuixin, Cen_US
dc.contributor.authorBenchang, Sen_US
dc.contributor.authorAiping, Ben_US
dc.contributor.authorJinhui, Wen_US
dc.contributor.authorXiaoyan, Len_US
dc.contributor.authorYu, WBCen_US
dc.contributor.authorMinhu, Cen_US
dc.date.accessioned2012-09-05T05:28:27Z-
dc.date.available2012-09-05T05:28:27Z-
dc.date.issued2008en_US
dc.identifier.citationOncology, 2008, v. 73 n. 5-6, p. 357-365en_US
dc.identifier.issn0030-2414en_US
dc.identifier.urihttp://hdl.handle.net/10722/163178-
dc.description.abstractIn this paper, we investigated Cdx2 and claudin-2 expression in pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy to determine the correlation between the expressions of these 2 genes during gastric carcinogenesis by immunochemical ABC technique. Altogether, we analyzed 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples. Our results indicated that the percentage of Cdx2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 90.83% (99/109) for intestinal-type metaplasia, 51.61% (48/93) for dysplasia and 61.54% (32/52) for gastric intestinal-type adenocarcinoma, primarily expressed in the cell nucleus and partly in the cytoplasm (p < 0.05); interestingly, the percentage for the intestine-type metaplasia was markedly high. The percentage of claudin-2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 0% (0/109) for intestinal-type metaplasia, 35.48% (33/93) for dysplasia and 71.15% (37/52) for gastric intestinal-type adenocarcinoma, primarily in the cell membrane and gradually increased in the multistage process of gastric carcinogenesis (p < 0.05). Significant correlations were found between claudin-2 and Cdx2 protein expression in dysplasia and intestine-type adenocarcinoma (r = 0.112, p < 0.05). Thus, there may be a correlation between the expression of claudin-2 and Cdx2 in stages of dysplasia and cancer. Copyright © 2008 S. Karger AG.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCLen_US
dc.relation.ispartofOncologyen_US
dc.subject.meshAdenocarcinoma - Pathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastritis - Pathologyen_US
dc.subject.meshHomeodomain Proteins - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIntestinal Neoplasms - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteins - Metabolismen_US
dc.subject.meshMetaplasia - Parasitologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshStomach Neoplasms - Pathologyen_US
dc.titleExpression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesisen_US
dc.typeArticleen_US
dc.identifier.emailYu, WBC:bcywong@hku.hken_US
dc.identifier.authorityYu, WBC=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000135351en_US
dc.identifier.pmid18500171-
dc.identifier.scopuseid_2-s2.0-45549103908en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-45549103908&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume73en_US
dc.identifier.issue5-6en_US
dc.identifier.spage357en_US
dc.identifier.epage365en_US
dc.identifier.isiWOS:000256880100013-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridXin, S=36883450600en_US
dc.identifier.scopusauthoridHuixin, C=24390822000en_US
dc.identifier.scopusauthoridBenchang, S=24390659500en_US
dc.identifier.scopusauthoridAiping, B=24390454500en_US
dc.identifier.scopusauthoridJinhui, W=17434828000en_US
dc.identifier.scopusauthoridXiaoyan, L=36794351900en_US
dc.identifier.scopusauthoridYu, WBC=7402023340en_US
dc.identifier.scopusauthoridMinhu, C=15065636400en_US

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