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Article: Expression of claudin-2 in the multistage process of gastric carcinogenesis.

TitleExpression of claudin-2 in the multistage process of gastric carcinogenesis.
Authors
Issue Date2008
Citation
Histology And Histopathology, 2008, v. 23 n. 6, p. 673-682 How to Cite?
AbstractOBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/163161
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSong, Xen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorTang, Yen_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorWong, Ben_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorChen, Men_US
dc.date.accessioned2012-09-05T05:28:20Z-
dc.date.available2012-09-05T05:28:20Z-
dc.date.issued2008en_US
dc.identifier.citationHistology And Histopathology, 2008, v. 23 n. 6, p. 673-682en_US
dc.identifier.issn1699-5848en_US
dc.identifier.urihttp://hdl.handle.net/10722/163161-
dc.description.abstractOBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.en_US
dc.languageengen_US
dc.relation.ispartofHistology and histopathologyen_US
dc.subject.meshAdenocarcinoma - Metabolism - Pathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Technique, Indirecten_US
dc.subject.meshGastric Mucosa - Metabolism - Pathologyen_US
dc.subject.meshGastritis, Atrophic - Metabolism - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperplasia - Metabolism - Pathologyen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteins - Metabolismen_US
dc.subject.meshMetaplasia - Metabolism - Pathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrecancerous Conditions - Metabolism - Pathologyen_US
dc.subject.meshStomach Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshTumor Markers, Biological - Metabolismen_US
dc.titleExpression of claudin-2 in the multistage process of gastric carcinogenesis.en_US
dc.typeArticleen_US
dc.identifier.emailWong, B:bcywong@hku.hken_US
dc.identifier.authorityWong, B=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid18366005en_US
dc.identifier.scopuseid_2-s2.0-42149186503en_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.spage673en_US
dc.identifier.epage682en_US
dc.identifier.isiWOS:000254993700003-
dc.identifier.scopusauthoridSong, X=13002663000en_US
dc.identifier.scopusauthoridLi, X=23469678400en_US
dc.identifier.scopusauthoridTang, Y=35187706500en_US
dc.identifier.scopusauthoridChen, H=8834467700en_US
dc.identifier.scopusauthoridWong, B=7402023340en_US
dc.identifier.scopusauthoridWang, J=34977817900en_US
dc.identifier.scopusauthoridChen, M=8642044500en_US

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