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Article: Expression of claudin-2 in the multistage process of gastric carcinogenesis.
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TitleExpression of claudin-2 in the multistage process of gastric carcinogenesis.
 
AuthorsSong, X2
Li, X2
Tang, Y2
Chen, H2
Wong, B1
Wang, J2
Chen, M2
 
Issue Date2008
 
CitationHistology And Histopathology, 2008, v. 23 n. 6, p. 673-682 [How to Cite?]
 
AbstractOBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.
 
ISSN1699-5848
 
ISI Accession Number IDWOS:000254993700003
 
DC FieldValue
dc.contributor.authorSong, X
 
dc.contributor.authorLi, X
 
dc.contributor.authorTang, Y
 
dc.contributor.authorChen, H
 
dc.contributor.authorWong, B
 
dc.contributor.authorWang, J
 
dc.contributor.authorChen, M
 
dc.date.accessioned2012-09-05T05:28:20Z
 
dc.date.available2012-09-05T05:28:20Z
 
dc.date.issued2008
 
dc.description.abstractOBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHistology And Histopathology, 2008, v. 23 n. 6, p. 673-682 [How to Cite?]
 
dc.identifier.epage682
 
dc.identifier.isiWOS:000254993700003
 
dc.identifier.issn1699-5848
 
dc.identifier.issue6
 
dc.identifier.pmid18366005
 
dc.identifier.scopuseid_2-s2.0-42149186503
 
dc.identifier.spage673
 
dc.identifier.urihttp://hdl.handle.net/10722/163161
 
dc.identifier.volume23
 
dc.languageeng
 
dc.relation.ispartofHistology and histopathology
 
dc.subject.meshAdenocarcinoma - Metabolism - Pathology
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshFemale
 
dc.subject.meshFluorescent Antibody Technique, Indirect
 
dc.subject.meshGastric Mucosa - Metabolism - Pathology
 
dc.subject.meshGastritis, Atrophic - Metabolism - Pathology
 
dc.subject.meshHumans
 
dc.subject.meshHyperplasia - Metabolism - Pathology
 
dc.subject.meshImmunoenzyme Techniques
 
dc.subject.meshMale
 
dc.subject.meshMembrane Proteins - Metabolism
 
dc.subject.meshMetaplasia - Metabolism - Pathology
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPrecancerous Conditions - Metabolism - Pathology
 
dc.subject.meshStomach Neoplasms - Metabolism - Pathology
 
dc.subject.meshTumor Markers, Biological - Metabolism
 
dc.titleExpression of claudin-2 in the multistage process of gastric carcinogenesis.
 
dc.typeArticle
 
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<item><contributor.author>Song, X</contributor.author>
<contributor.author>Li, X</contributor.author>
<contributor.author>Tang, Y</contributor.author>
<contributor.author>Chen, H</contributor.author>
<contributor.author>Wong, B</contributor.author>
<contributor.author>Wang, J</contributor.author>
<contributor.author>Chen, M</contributor.author>
<date.accessioned>2012-09-05T05:28:20Z</date.accessioned>
<date.available>2012-09-05T05:28:20Z</date.available>
<date.issued>2008</date.issued>
<identifier.citation>Histology And Histopathology, 2008, v. 23 n. 6, p. 673-682</identifier.citation>
<identifier.issn>1699-5848</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/163161</identifier.uri>
<description.abstract>OBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P&lt;0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.</description.abstract>
<language>eng</language>
<relation.ispartof>Histology and histopathology</relation.ispartof>
<subject.mesh>Adenocarcinoma - Metabolism - Pathology</subject.mesh>
<subject.mesh>Adolescent</subject.mesh>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Aged</subject.mesh>
<subject.mesh>Aged, 80 And Over</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Fluorescent Antibody Technique, Indirect</subject.mesh>
<subject.mesh>Gastric Mucosa - Metabolism - Pathology</subject.mesh>
<subject.mesh>Gastritis, Atrophic - Metabolism - Pathology</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Hyperplasia - Metabolism - Pathology</subject.mesh>
<subject.mesh>Immunoenzyme Techniques</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Membrane Proteins - Metabolism</subject.mesh>
<subject.mesh>Metaplasia - Metabolism - Pathology</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Precancerous Conditions - Metabolism - Pathology</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University