Article: Expression of claudin-2 in the multistage process of gastric carcinogenesis.

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TitleExpression of claudin-2 in the multistage process of gastric carcinogenesis.
AuthorsSong, X2
Li, X2
Tang, Y2
Chen, H2
Wong, B1
Wang, J2
Chen, M2
Issue Date2008
CitationHistology And Histopathology, 2008, v. 23 n. 6, p. 673-682 [How to Cite?]
AbstractOBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.
ISSN1699-5848
DC Field
Value
dc.contributor.authorSong, X
dc.contributor.authorLi, X
dc.contributor.authorTang, Y
dc.contributor.authorChen, H
dc.contributor.authorWong, B
dc.contributor.authorWang, J
dc.contributor.authorChen, M
dc.date.accessioned2012-09-05T05:28:20Z
dc.date.available2012-09-05T05:28:20Z
dc.date.issued2008
dc.description.abstractOBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHistology And Histopathology, 2008, v. 23 n. 6, p. 673-682 [How to Cite?]
dc.identifier.epage682
dc.identifier.issn1699-5848
dc.identifier.issue6
dc.identifier.pmid18366005
dc.identifier.scopuseid_2-s2.0-42149186503
dc.identifier.spage673
dc.identifier.urihttp://hdl.handle.net/10722/163161
dc.identifier.volume23
dc.languageeng
dc.relation.ispartofHistology and histopathology
dc.subject.meshAdenocarcinoma - Metabolism - Pathology
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 And Over
dc.subject.meshFemale
dc.subject.meshFluorescent Antibody Technique, Indirect
dc.subject.meshGastric Mucosa - Metabolism - Pathology
dc.subject.meshGastritis, Atrophic - Metabolism - Pathology
dc.subject.meshHumans
dc.subject.meshHyperplasia - Metabolism - Pathology
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshMale
dc.subject.meshMembrane Proteins - Metabolism
dc.subject.meshMetaplasia - Metabolism - Pathology
dc.subject.meshMiddle Aged
dc.subject.meshPrecancerous Conditions - Metabolism - Pathology
dc.subject.meshStomach Neoplasms - Metabolism - Pathology
dc.subject.meshTumor Markers, Biological - Metabolism
dc.titleExpression of claudin-2 in the multistage process of gastric carcinogenesis.
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University