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Article: Pathogenesis of COPD. Part II. Oxidative-antioxidative imbalance

TitlePathogenesis of COPD. Part II. Oxidative-antioxidative imbalance
Authors
Issue Date2008
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2008, v. 12 n. 4, p. 368-374 How to Cite?
AbstractChronic obstructive pulmonary disease (COPD) represents a serious global health problem that affects the aged. This State of the Art article summarises previous studies on oxidative-antioxidative imbalance in patients with stable COPD or in acute exacerbations. Recent literature in this field reports conflicting findings. Several studies on markers of oxidative stress have demonstrated increased production of oxidants in exhaled air, breath condensates or induced sputum. The primary defence against oxidants is endogenous antioxidants, which are altered in COPD. Some studies have demonstrated a marked decrease in plasma antioxidant capacity, while other studies have shown opposite findings. A few studies have shown higher erythrocyte superoxide dismutase (SOD) activity in COPD patients and healthy smokers than those in healthy non-smokers. In contrast, we found no differences in erythrocyte SOD activity and elevated erythrocyte catalase activity in Chinese patients with COPD compared with healthy smokers matched for age and pack-years smoked. Possible reasons for such discrepancies could be related to differences in inter-individual variations in antioxidant capacity as a result of different populations and also differences in methodologies between studies. © 2008 The Union.
Persistent Identifierhttp://hdl.handle.net/10722/163159
ISSN
2015 Impact Factor: 2.148
2015 SCImago Journal Rankings: 1.381
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_US
dc.date.accessioned2012-09-05T05:28:16Z-
dc.date.available2012-09-05T05:28:16Z-
dc.date.issued2008en_US
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2008, v. 12 n. 4, p. 368-374en_US
dc.identifier.issn1027-3719en_US
dc.identifier.urihttp://hdl.handle.net/10722/163159-
dc.description.abstractChronic obstructive pulmonary disease (COPD) represents a serious global health problem that affects the aged. This State of the Art article summarises previous studies on oxidative-antioxidative imbalance in patients with stable COPD or in acute exacerbations. Recent literature in this field reports conflicting findings. Several studies on markers of oxidative stress have demonstrated increased production of oxidants in exhaled air, breath condensates or induced sputum. The primary defence against oxidants is endogenous antioxidants, which are altered in COPD. Some studies have demonstrated a marked decrease in plasma antioxidant capacity, while other studies have shown opposite findings. A few studies have shown higher erythrocyte superoxide dismutase (SOD) activity in COPD patients and healthy smokers than those in healthy non-smokers. In contrast, we found no differences in erythrocyte SOD activity and elevated erythrocyte catalase activity in Chinese patients with COPD compared with healthy smokers matched for age and pack-years smoked. Possible reasons for such discrepancies could be related to differences in inter-individual variations in antioxidant capacity as a result of different populations and also differences in methodologies between studies. © 2008 The Union.en_US
dc.languageengen_US
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_US
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_US
dc.subject.meshAntioxidants - Analysisen_US
dc.subject.meshCatalase - Metabolismen_US
dc.subject.meshErythrocytes - Enzymologyen_US
dc.subject.meshGlutathione - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshOxidants - Antagonists & Inhibitors - Blooden_US
dc.subject.meshOxidative Stress - Physiologyen_US
dc.subject.meshPneumonia - Physiopathologyen_US
dc.subject.meshPulmonary Disease, Chronic Obstructive - Etiology - Metabolismen_US
dc.subject.meshSmoking - Adverse Effects - Physiopathologyen_US
dc.subject.meshSuperoxide Dismutase - Blooden_US
dc.subject.meshWorld Healthen_US
dc.titlePathogenesis of COPD. Part II. Oxidative-antioxidative imbalanceen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid18371260-
dc.identifier.scopuseid_2-s2.0-41949123520en_US
dc.identifier.hkuros143198-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41949123520&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.spage368en_US
dc.identifier.epage374en_US
dc.identifier.isiWOS:000254186200005-
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US

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