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Article: Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

TitlePolymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD
Authors
Issue Date2007
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2007, v. 30 n. 4, p. 684-690 How to Cite?
AbstractIncreased oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the risk of COPD and the substitution of alanine 16 with valine (Ala16Val) polymorphism of manganese-superoxide dismutase (Mn-SOD) and the cytosine to thymidine transition of nucleotide -262 (-262C>T) polymorphism of the catalase gene, and the activity of erythrocyte SOD and catalase. The subjects were stable COPD patient ever smokers (n=165) and healthy controls, matched for age and cigarette consumption. Genotyping of Mn-SOD at Ala16Val and the catalase gene at -262C>T was performed, and the functional activity of SOD and catalase in erythrocytes determined. There were no significant differences in the distribution of the different genotypes or allele frequencies between patients and controls for both the Mn-SOD and catalase genes. Among healthy controls or COPD patients, no differences were observed in erythrocyte SOD and catalase activity, irrespective of genotype. Significantly higher erythrocyte catalase activity was found in COPD patients than in healthy controls. The T/T catalase genotype and Ala/Ala Mn-SOD genotype were uncommon in the present Chinese population. The increase in erythrocyte catalase activity in Chinese patients with chronic obstructive pulmonary disease probably indicates dysfunction of the oxidant/antioxidant defence system, but it is unclear whether this increase is compensatory or a pathogenic factor. Copyright©ERS Journals Ltd 2007.
Persistent Identifierhttp://hdl.handle.net/10722/163137
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_US
dc.contributor.authorHo, SPen_US
dc.contributor.authorYu, WCen_US
dc.contributor.authorChoo, KLen_US
dc.contributor.authorChu, CMen_US
dc.contributor.authorYew, WWen_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorChan-Yeung, Men_US
dc.date.accessioned2012-09-05T05:28:03Z-
dc.date.available2012-09-05T05:28:03Z-
dc.date.issued2007en_US
dc.identifier.citationEuropean Respiratory Journal, 2007, v. 30 n. 4, p. 684-690en_US
dc.identifier.issn0903-1936en_US
dc.identifier.urihttp://hdl.handle.net/10722/163137-
dc.description.abstractIncreased oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the risk of COPD and the substitution of alanine 16 with valine (Ala16Val) polymorphism of manganese-superoxide dismutase (Mn-SOD) and the cytosine to thymidine transition of nucleotide -262 (-262C>T) polymorphism of the catalase gene, and the activity of erythrocyte SOD and catalase. The subjects were stable COPD patient ever smokers (n=165) and healthy controls, matched for age and cigarette consumption. Genotyping of Mn-SOD at Ala16Val and the catalase gene at -262C>T was performed, and the functional activity of SOD and catalase in erythrocytes determined. There were no significant differences in the distribution of the different genotypes or allele frequencies between patients and controls for both the Mn-SOD and catalase genes. Among healthy controls or COPD patients, no differences were observed in erythrocyte SOD and catalase activity, irrespective of genotype. Significantly higher erythrocyte catalase activity was found in COPD patients than in healthy controls. The T/T catalase genotype and Ala/Ala Mn-SOD genotype were uncommon in the present Chinese population. The increase in erythrocyte catalase activity in Chinese patients with chronic obstructive pulmonary disease probably indicates dysfunction of the oxidant/antioxidant defence system, but it is unclear whether this increase is compensatory or a pathogenic factor. Copyright©ERS Journals Ltd 2007.en_US
dc.languageengen_US
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_US
dc.relation.ispartofEuropean Respiratory Journalen_US
dc.subject.meshAgeden_US
dc.subject.meshCatalase - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshErythrocytes - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPulmonary Disease, Chronic Obstructive - Diagnosis - Geneticsen_US
dc.subject.meshSmokingen_US
dc.subject.meshSuperoxide Dismutase - Geneticsen_US
dc.subject.meshValine - Chemistryen_US
dc.titlePolymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPDen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1183/09031936.00015207en_US
dc.identifier.pmid17567676-
dc.identifier.scopuseid_2-s2.0-38449108555en_US
dc.identifier.hkuros150587-
dc.identifier.hkuros137460-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38449108555&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue4en_US
dc.identifier.spage684en_US
dc.identifier.epage690en_US
dc.identifier.isiWOS:000250135400014-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridHo, SP=12794365900en_US
dc.identifier.scopusauthoridYu, WC=7403914214en_US
dc.identifier.scopusauthoridChoo, KL=23391819100en_US
dc.identifier.scopusauthoridChu, CM=7404345558en_US
dc.identifier.scopusauthoridYew, WW=7005934631en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridChan-Yeung, M=54790582200en_US
dc.customcontrol.immutablejt 130806-

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