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Article: Genetic polymorphisms and plasma levels of transforming growth factor-β 1 in Chinese patients with tuberculosis in Hong Kong

TitleGenetic polymorphisms and plasma levels of transforming growth factor-β 1 in Chinese patients with tuberculosis in Hong Kong
Authors
Issue Date2007
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/cytokine
Citation
Cytokine, 2007, v. 40 n. 3, p. 177-182 How to Cite?
AbstractSusceptibility to tuberculosis (TB) may be affected by host genetic factors. Elevated levels of transforming growth factor-beta 1 (TGF-β 1) were found in plasma of patients with active TB compared with those of healthy contacts. To investigate the association of TGF-β 1 gene polymorphisms (C-509T and T869C) and plasma levels with the risk of TB in Hong Kong Chinese adults, a case-control study was carried out on 174 active TB patients and 174 healthy controls matched for age, gender and smoking. Blood samples from 180 blood donors served as another control group. Genotyping was carried out on genomic DNA using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Plasma TGF-β 1 was measured by commercially available ELISA kit. We found no differences in the distribution of genotypes or alleles of TGF-β 1 gene polymorphisms at C-509T and T869C between patients and either group of healthy controls. Patients with TB had elevated plasma TGF-β 1 levels compared with healthy controls irrespective of their genotypes (p < 0.001). In conclusion, TGF-β 1 gene polymorphism at C-509T and T869C is not associated with TB susceptibility in Hong Kong Chinese adults, but elevated plasma TGF-β 1 levels suggests that this cytokine may play a role in the pathogenesis of tuberculosis. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163131
ISSN
2015 Impact Factor: 2.94
2015 SCImago Journal Rankings: 1.294
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_US
dc.contributor.authorLeung, HCMen_US
dc.contributor.authorSham, ASKen_US
dc.contributor.authorMok, TYWen_US
dc.contributor.authorPoon, YNen_US
dc.contributor.authorLing, SOen_US
dc.contributor.authorWong, KCen_US
dc.contributor.authorChanYeung, Men_US
dc.date.accessioned2012-09-05T05:27:59Z-
dc.date.available2012-09-05T05:27:59Z-
dc.date.issued2007en_US
dc.identifier.citationCytokine, 2007, v. 40 n. 3, p. 177-182en_US
dc.identifier.issn1043-4666en_US
dc.identifier.urihttp://hdl.handle.net/10722/163131-
dc.description.abstractSusceptibility to tuberculosis (TB) may be affected by host genetic factors. Elevated levels of transforming growth factor-beta 1 (TGF-β 1) were found in plasma of patients with active TB compared with those of healthy contacts. To investigate the association of TGF-β 1 gene polymorphisms (C-509T and T869C) and plasma levels with the risk of TB in Hong Kong Chinese adults, a case-control study was carried out on 174 active TB patients and 174 healthy controls matched for age, gender and smoking. Blood samples from 180 blood donors served as another control group. Genotyping was carried out on genomic DNA using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Plasma TGF-β 1 was measured by commercially available ELISA kit. We found no differences in the distribution of genotypes or alleles of TGF-β 1 gene polymorphisms at C-509T and T869C between patients and either group of healthy controls. Patients with TB had elevated plasma TGF-β 1 levels compared with healthy controls irrespective of their genotypes (p < 0.001). In conclusion, TGF-β 1 gene polymorphism at C-509T and T869C is not associated with TB susceptibility in Hong Kong Chinese adults, but elevated plasma TGF-β 1 levels suggests that this cytokine may play a role in the pathogenesis of tuberculosis. © 2007 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/cytokineen_US
dc.relation.ispartofCytokineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshTransforming Growth Factor Beta1 - Blood - Geneticsen_US
dc.subject.meshTuberculosis, Pulmonary - Blood - Geneticsen_US
dc.titleGenetic polymorphisms and plasma levels of transforming growth factor-β 1 in Chinese patients with tuberculosis in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cyto.2007.09.006en_US
dc.identifier.pmid18029191-
dc.identifier.scopuseid_2-s2.0-36849058180en_US
dc.identifier.hkuros143197-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36849058180&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume40en_US
dc.identifier.issue3en_US
dc.identifier.spage177en_US
dc.identifier.epage182en_US
dc.identifier.isiWOS:000252204800004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridLeung, HCM=34968372500en_US
dc.identifier.scopusauthoridSham, ASK=55225014100en_US
dc.identifier.scopusauthoridMok, TYW=8706357200en_US
dc.identifier.scopusauthoridPoon, YN=23036197100en_US
dc.identifier.scopusauthoridLing, SO=16642976900en_US
dc.identifier.scopusauthoridWong, KC=37096575600en_US
dc.identifier.scopusauthoridChanYeung, M=54790582200en_US

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