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Article: A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women
Title | A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women |
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Authors | |
Keywords | ALOX15 Association study BMD Chinese Gene-environment interaction Genetic association Haplotype Osteoporosis SNP |
Issue Date | 2007 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/HHE |
Citation | Human Heredity, 2007, v. 65 n. 1, p. 1-8 How to Cite? |
Abstract | Objective: The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss. The aim of the present study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. Methods: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score ≤-1.28 at either the hip or spine) or high BMD (Z score ≥+1). Single locus and haplotype associations were performed using logistic regression with adjustment of age, height and weight. Results: The variant 'G' allele of rs2619112 was associated with a reduced risk of low BMD at the femoral neck in pre-menopausal women (OR = 0.442, p = 0.007) but an increased risk in post-menopausal women (OR = 1.727, p = 0.042). Haplotype analysis revealed findings similar to the single locus tests. Conclusion: The variant alleles of rs2619112 and rs916055 and their haplotypes of ALOX15 are associated with high BMD in pre-menopausal women but low BMD in post-menopausal women. This suggests that ALOX15 is a dual modulator of BMD variation with opposing effects in pre- and post-menopausal women. Copyright © 2008 S. Karger AG. |
Persistent Identifier | http://hdl.handle.net/10722/163118 |
ISSN | 2023 Impact Factor: 1.1 2023 SCImago Journal Rankings: 0.483 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Cheung, CL | en_HK |
dc.contributor.author | Chan, V | en_HK |
dc.contributor.author | Kung, AWC | en_HK |
dc.date.accessioned | 2012-09-05T05:27:51Z | - |
dc.date.available | 2012-09-05T05:27:51Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Human Heredity, 2007, v. 65 n. 1, p. 1-8 | en_HK |
dc.identifier.issn | 0001-5652 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163118 | - |
dc.description.abstract | Objective: The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss. The aim of the present study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. Methods: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score ≤-1.28 at either the hip or spine) or high BMD (Z score ≥+1). Single locus and haplotype associations were performed using logistic regression with adjustment of age, height and weight. Results: The variant 'G' allele of rs2619112 was associated with a reduced risk of low BMD at the femoral neck in pre-menopausal women (OR = 0.442, p = 0.007) but an increased risk in post-menopausal women (OR = 1.727, p = 0.042). Haplotype analysis revealed findings similar to the single locus tests. Conclusion: The variant alleles of rs2619112 and rs916055 and their haplotypes of ALOX15 are associated with high BMD in pre-menopausal women but low BMD in post-menopausal women. This suggests that ALOX15 is a dual modulator of BMD variation with opposing effects in pre- and post-menopausal women. Copyright © 2008 S. Karger AG. | en_HK |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/HHE | en_HK |
dc.relation.ispartof | Human Heredity | en_HK |
dc.rights | Human Heredity. Copyright © S Karger AG. | - |
dc.subject | ALOX15 | en_HK |
dc.subject | Association study | en_HK |
dc.subject | BMD | en_HK |
dc.subject | Chinese | en_HK |
dc.subject | Gene-environment interaction | en_HK |
dc.subject | Genetic association | en_HK |
dc.subject | Haplotype | en_HK |
dc.subject | Osteoporosis | en_HK |
dc.subject | SNP | en_HK |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Alleles | en_US |
dc.subject.mesh | Arachidonate 15-Lipoxygenase - Genetics | en_US |
dc.subject.mesh | Bone Density - Genetics | en_US |
dc.subject.mesh | Chromosomes, Human, Pair 17 | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Haplotypes | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Linkage Disequilibrium | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_US |
dc.subject.mesh | Postmenopause | en_US |
dc.subject.mesh | Premenopause | en_US |
dc.title | A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cheung, CL: lung1212@hku.hk | en_HK |
dc.identifier.email | Chan, V: vnychana@hkucc.hku.hk | en_HK |
dc.identifier.email | Kung, AWC: awckung@hku.hk | en_HK |
dc.identifier.authority | Cheung, CL=rp01749 | en_HK |
dc.identifier.authority | Chan, V=rp00320 | en_HK |
dc.identifier.authority | Kung, AWC=rp00368 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1159/000106057 | en_HK |
dc.identifier.pmid | 17652958 | - |
dc.identifier.scopus | eid_2-s2.0-35148830836 | en_HK |
dc.identifier.hkuros | 151992 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-35148830836&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 65 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 1 | en_HK |
dc.identifier.epage | 8 | en_HK |
dc.identifier.isi | WOS:000249305300001 | - |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Cheung, CL=14520953400 | en_HK |
dc.identifier.scopusauthorid | Chan, V=7202654865 | en_HK |
dc.identifier.scopusauthorid | Kung, AWC=7102322339 | en_HK |
dc.identifier.issnl | 0001-5652 | - |