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Article: A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women

TitleA differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women
Authors
KeywordsALOX15
Association study
BMD
Chinese
Gene-environment interaction
Genetic association
Haplotype
Osteoporosis
SNP
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHE
Citation
Human Heredity, 2007, v. 65 n. 1, p. 1-8 How to Cite?
AbstractObjective: The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss. The aim of the present study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. Methods: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score ≤-1.28 at either the hip or spine) or high BMD (Z score ≥+1). Single locus and haplotype associations were performed using logistic regression with adjustment of age, height and weight. Results: The variant 'G' allele of rs2619112 was associated with a reduced risk of low BMD at the femoral neck in pre-menopausal women (OR = 0.442, p = 0.007) but an increased risk in post-menopausal women (OR = 1.727, p = 0.042). Haplotype analysis revealed findings similar to the single locus tests. Conclusion: The variant alleles of rs2619112 and rs916055 and their haplotypes of ALOX15 are associated with high BMD in pre-menopausal women but low BMD in post-menopausal women. This suggests that ALOX15 is a dual modulator of BMD variation with opposing effects in pre- and post-menopausal women. Copyright © 2008 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/163118
ISSN
2015 Impact Factor: 1.539
2015 SCImago Journal Rankings: 0.942
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2012-09-05T05:27:51Z-
dc.date.available2012-09-05T05:27:51Z-
dc.date.issued2007en_HK
dc.identifier.citationHuman Heredity, 2007, v. 65 n. 1, p. 1-8en_HK
dc.identifier.issn0001-5652en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163118-
dc.description.abstractObjective: The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss. The aim of the present study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. Methods: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score ≤-1.28 at either the hip or spine) or high BMD (Z score ≥+1). Single locus and haplotype associations were performed using logistic regression with adjustment of age, height and weight. Results: The variant 'G' allele of rs2619112 was associated with a reduced risk of low BMD at the femoral neck in pre-menopausal women (OR = 0.442, p = 0.007) but an increased risk in post-menopausal women (OR = 1.727, p = 0.042). Haplotype analysis revealed findings similar to the single locus tests. Conclusion: The variant alleles of rs2619112 and rs916055 and their haplotypes of ALOX15 are associated with high BMD in pre-menopausal women but low BMD in post-menopausal women. This suggests that ALOX15 is a dual modulator of BMD variation with opposing effects in pre- and post-menopausal women. Copyright © 2008 S. Karger AG.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHEen_HK
dc.relation.ispartofHuman Heredityen_HK
dc.rightsHuman Heredity. Copyright © S Karger AG.-
dc.subjectALOX15en_HK
dc.subjectAssociation studyen_HK
dc.subjectBMDen_HK
dc.subjectChineseen_HK
dc.subjectGene-environment interactionen_HK
dc.subjectGenetic associationen_HK
dc.subjectHaplotypeen_HK
dc.subjectOsteoporosisen_HK
dc.subjectSNPen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshArachidonate 15-Lipoxygenase - Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshFemaleen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshPostmenopauseen_US
dc.subject.meshPremenopauseen_US
dc.titleA differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal womenen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1159/000106057en_HK
dc.identifier.pmid17652958-
dc.identifier.scopuseid_2-s2.0-35148830836en_HK
dc.identifier.hkuros151992-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35148830836&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage8en_HK
dc.identifier.isiWOS:000249305300001-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

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