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Article: Polymorphisms in the IL-4, IL-4 receptor α chain, TNF-α, and lymphotoxin-α genes and risk of asthma in Hong Kong Chinese adults

TitlePolymorphisms in the IL-4, IL-4 receptor α chain, TNF-α, and lymphotoxin-α genes and risk of asthma in Hong Kong Chinese adults
Authors
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/IAA
Citation
International Archives Of Allergy And Immunology, 2007, v. 144 n. 2, p. 114-122 How to Cite?
AbstractBackground: Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. However, association studies with interleukin-4 (IL-4), IL-4 receptor α subunit (IL-4Rα), tumor necrosis factor-α (TNF-α) and lymphotoxin-α (LT-α) genes were inconclusive, as both positive and negative results were obtained in several populations studied. We aimed to investigate the association of the polymorphisms for IL-4 (C-589T), IL-4Rα (Gln576Arg), TNF-α (G-308A) and LT-α (A252G) genes as candidates and asthma in adult Hong Kong Chinese population. Methods: The association study was conducted in an age- and smoking status-matched case-control design in asthma patients (n = 292) and healthy controls (n = 292) using polymerase chain reaction and restriction fragment length polymorphism. Results: No significant differences were found in allele and genotype frequencies of all four genes between patients and controls. After stratification by atopic status, the heterozygous AG genotype of LT-α (A252G) was found to increase risk of asthma in atopic population [odds ratio (OR) = 2.00, 95% CI 1.09-3.67, p = 0.024]. When stratified by smoking status, we found increased risk of asthma with subjects carrying the heterozygous AG and homozygous GG genotypes of LT-α in ever-smokers (OR = 2.73, 95% CI 1.11-6.69, p = 0.028 for heterozygotes; OR = 3.34, 95% CI 1.16-9.62, p = 0.026 for homozygotes). Conclusion: Our results suggest that the variability of LT-α genotypes may have potential implications for individual susceptibility to asthma in atopic or in ever-smoking Chinese adults in Hong Kong. Copyright © 2007 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/163107
ISSN
2015 Impact Factor: 2.677
2015 SCImago Journal Rankings: 1.164
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_US
dc.contributor.authorKo, FWSen_US
dc.contributor.authorChu, CMen_US
dc.contributor.authorLeung, HCMen_US
dc.contributor.authorChan, HWen_US
dc.contributor.authorCheung, AHKen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorChanYeung, Men_US
dc.date.accessioned2012-09-05T05:27:41Z-
dc.date.available2012-09-05T05:27:41Z-
dc.date.issued2007en_US
dc.identifier.citationInternational Archives Of Allergy And Immunology, 2007, v. 144 n. 2, p. 114-122en_US
dc.identifier.issn1018-2438en_US
dc.identifier.urihttp://hdl.handle.net/10722/163107-
dc.description.abstractBackground: Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. However, association studies with interleukin-4 (IL-4), IL-4 receptor α subunit (IL-4Rα), tumor necrosis factor-α (TNF-α) and lymphotoxin-α (LT-α) genes were inconclusive, as both positive and negative results were obtained in several populations studied. We aimed to investigate the association of the polymorphisms for IL-4 (C-589T), IL-4Rα (Gln576Arg), TNF-α (G-308A) and LT-α (A252G) genes as candidates and asthma in adult Hong Kong Chinese population. Methods: The association study was conducted in an age- and smoking status-matched case-control design in asthma patients (n = 292) and healthy controls (n = 292) using polymerase chain reaction and restriction fragment length polymorphism. Results: No significant differences were found in allele and genotype frequencies of all four genes between patients and controls. After stratification by atopic status, the heterozygous AG genotype of LT-α (A252G) was found to increase risk of asthma in atopic population [odds ratio (OR) = 2.00, 95% CI 1.09-3.67, p = 0.024]. When stratified by smoking status, we found increased risk of asthma with subjects carrying the heterozygous AG and homozygous GG genotypes of LT-α in ever-smokers (OR = 2.73, 95% CI 1.11-6.69, p = 0.028 for heterozygotes; OR = 3.34, 95% CI 1.16-9.62, p = 0.026 for homozygotes). Conclusion: Our results suggest that the variability of LT-α genotypes may have potential implications for individual susceptibility to asthma in atopic or in ever-smoking Chinese adults in Hong Kong. Copyright © 2007 S. Karger AG.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/IAAen_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshAsthma - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHong Kong - Ethnologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-4 - Geneticsen_US
dc.subject.meshInterleukin-4 Receptor Alpha Subunit - Geneticsen_US
dc.subject.meshLymphotoxin-Alpha - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshTumor Necrosis Factor-Alpha - Geneticsen_US
dc.titlePolymorphisms in the IL-4, IL-4 receptor α chain, TNF-α, and lymphotoxin-α genes and risk of asthma in Hong Kong Chinese adultsen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000103222en_US
dc.identifier.pmid17536219en_US
dc.identifier.scopuseid_2-s2.0-34548689374en_US
dc.identifier.hkuros134896-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548689374&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume144en_US
dc.identifier.issue2en_US
dc.identifier.spage114en_US
dc.identifier.epage122en_US
dc.identifier.isiWOS:000249003700003-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridKo, FWS=7103224911en_US
dc.identifier.scopusauthoridChu, CM=7404345558en_US
dc.identifier.scopusauthoridLeung, HCM=34968372500en_US
dc.identifier.scopusauthoridChan, HW=8926625400en_US
dc.identifier.scopusauthoridCheung, AHK=12795914100en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridChanYeung, M=54790582200en_US

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