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Article: The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population

TitleThe association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population
Authors
KeywordsAssociation
BMD
Genetics
Osteoporosis
Tag SNPs
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html
Citation
Journal Of Human Genetics, 2007, v. 52 n. 9, p. 757-762 How to Cite?
AbstractEvidence of the linkage of chromosome 2p to bone mineral density (BMD) has previously been reported in multiple populations. However, the identification of the BMD quantitative trait loci (QTL) gene at chromosome 2p remains a challenge. We performed a gene-wide and tag single nucleotide polymorphism (SNP)-based association study of four positional and functional candidate genes (CALM2, CYP1B1, QPCT, and POMC) in a sample of 1,243 cases and matched controls. Thirteen HapMap tag SNPs were selected and genotyped by using the high-throughput Sequenom genotyping platform. Binary logistic regression analyses were performed to test for associations between each SNP genotype and BMD. Haplotype association analyses were performed by WHAP. The rs3770748 within the QPCT gene showed a significant association with spine BMD in both single-marker (P = 0.002) and haplotype association analyses (P = 0.0482 for the global test; P = 0.00092 for the haplotype-specific test). Subgroup analysis revealed that the effect was primarily driven by an association in the postmenopausal women, presumably suggesting that the rs3770748 affects postmenopausal bone loss rather than peak bone mass. Our results suggest that QPCT may be the QTL gene at chromosome 2p for spine BMD variation in the Chinese population. © 2007 The Japan Society of Human Genetics and Springer.
Persistent Identifierhttp://hdl.handle.net/10722/163104
ISSN
2015 Impact Factor: 2.487
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, QYen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2012-09-05T05:27:39Z-
dc.date.available2012-09-05T05:27:39Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Human Genetics, 2007, v. 52 n. 9, p. 757-762en_HK
dc.identifier.issn1434-5161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163104-
dc.description.abstractEvidence of the linkage of chromosome 2p to bone mineral density (BMD) has previously been reported in multiple populations. However, the identification of the BMD quantitative trait loci (QTL) gene at chromosome 2p remains a challenge. We performed a gene-wide and tag single nucleotide polymorphism (SNP)-based association study of four positional and functional candidate genes (CALM2, CYP1B1, QPCT, and POMC) in a sample of 1,243 cases and matched controls. Thirteen HapMap tag SNPs were selected and genotyped by using the high-throughput Sequenom genotyping platform. Binary logistic regression analyses were performed to test for associations between each SNP genotype and BMD. Haplotype association analyses were performed by WHAP. The rs3770748 within the QPCT gene showed a significant association with spine BMD in both single-marker (P = 0.002) and haplotype association analyses (P = 0.0482 for the global test; P = 0.00092 for the haplotype-specific test). Subgroup analysis revealed that the effect was primarily driven by an association in the postmenopausal women, presumably suggesting that the rs3770748 affects postmenopausal bone loss rather than peak bone mass. Our results suggest that QPCT may be the QTL gene at chromosome 2p for spine BMD variation in the Chinese population. © 2007 The Japan Society of Human Genetics and Springer.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.htmlen_HK
dc.relation.ispartofJournal of Human Geneticsen_HK
dc.subjectAssociationen_HK
dc.subjectBMDen_HK
dc.subjectGeneticsen_HK
dc.subjectOsteoporosisen_HK
dc.subjectTag SNPsen_HK
dc.subject.meshAgeden_US
dc.subject.meshAminoacyltransferases - Genetics - Metabolismen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenetics, Populationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteoporosis, Postmenopausal - Ethnology - Geneticsen_US
dc.subject.meshPituitary Gland - Enzymologyen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshQuantitative Trait Locien_US
dc.titleThe association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.emailHuang, QY: qyhuang@hotmail.comen_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityHuang, QY=rp00521en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10038-007-0178-6en_HK
dc.identifier.pmid17687619-
dc.identifier.scopuseid_2-s2.0-34548589037en_HK
dc.identifier.hkuros141386-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548589037&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue9en_HK
dc.identifier.spage757en_HK
dc.identifier.epage762en_HK
dc.identifier.isiWOS:000249405800006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHuang, QY=7403630787en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike2079299-

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