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Article: Ten-year risk of osteoporotic fractures in postmenopausal Chinese women according to clinical risk factors and BMD T-scores: A prospective study

TitleTen-year risk of osteoporotic fractures in postmenopausal Chinese women according to clinical risk factors and BMD T-scores: A prospective study
Authors
KeywordsChinese
Fracture risk
Osteoporosis
Women
Issue Date2007
PublisherAmerican Society for Bone and Mineral Research. The Journal's web site is located at http://www.jbmr.org/view/0/index.html
Citation
Journal Of Bone And Mineral Research, 2007, v. 22 n. 7, p. 1080-1087 How to Cite?
AbstractIndependent risk factors for osteoporotic fracture were identified for a Southern Chinese postmenopausal population. Clinical risk factor assessment with or without BMD measurement was shown to be an effective predictor of 10-yr risk of osteoporotic fracture and provides a more accessible tool for patient evaluation. Introduction: Asian-specific data on risk factors for osteoporosis remain sparse. However, risk factor assessment, in addition to BMD measurement, is increasingly recognized as a reliable predictor of absolute osteoporotic fracture risk. The purpose of this prospective study was to determine the specific independent risk factors for osteoporotic fracture and to predict the 10-yr risk of osteoporotic fracture in the postmenopausal Southern Chinese population. Materials and Methods: A total of 1435 community-dwelling, postmenopausal, treatment-naive women were recruited. Baseline demographic characteristics and clinical risk factors were obtained, and BMD at the spine and hip was measured. Subjects were followed for outcomes of incident low trauma fracture. Ten-year risk of osteoporotic fracture was predicted from the risk factor assessment and BMD measurement by Cox proportional hazards models. Results: The mean age of subjects was 63.4 ± 8.3 yr. After 5.0 ± 2.3 yr (range, 1.0-11.0 yr) of follow-up, 80 nontraumatic new fractures were reported during follow-up. Eight independent clinical risk factors identified at baseline were found to be significant predictors of osteoporotic fracture, with the most important being use of walking aids (RR, 4.2; 95% CI, 2.7-6.7; p < 0.001) and a history of fall (RR, 4.0; 95% CI, 2.5-6.2; p < 0.001). Other predictive factors included being homebound, calcium intake < 400 mg/d, age > 65 yr, history of fracture, and BMI < 19 kg/cm2. Subjects with three to eight clinical risk factors had a predicted 10-year risk of osteoporotic fracture of 25%, which increased to 30% if they also had total hip BMD T-score ≤ -2.5. Conclusions: Clinical risk factor assessment, with or without BMD measurement, is a reliable predictor of 10-year risk of osteoporotic fracture and may be particularly useful in regions or primary care clinics without access to bone densitometry equipment. © 2007 American Society for Bone and Mineral Research.
Persistent Identifierhttp://hdl.handle.net/10722/163103
ISSN
2015 Impact Factor: 5.622
2015 SCImago Journal Rankings: 2.773
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_US
dc.contributor.authorLee, KKen_US
dc.contributor.authorHo, AYYen_US
dc.contributor.authorTang, Gen_US
dc.contributor.authorLuk, KDKen_US
dc.date.accessioned2012-09-05T05:27:39Z-
dc.date.available2012-09-05T05:27:39Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Bone And Mineral Research, 2007, v. 22 n. 7, p. 1080-1087en_US
dc.identifier.issn0884-0431en_US
dc.identifier.urihttp://hdl.handle.net/10722/163103-
dc.description.abstractIndependent risk factors for osteoporotic fracture were identified for a Southern Chinese postmenopausal population. Clinical risk factor assessment with or without BMD measurement was shown to be an effective predictor of 10-yr risk of osteoporotic fracture and provides a more accessible tool for patient evaluation. Introduction: Asian-specific data on risk factors for osteoporosis remain sparse. However, risk factor assessment, in addition to BMD measurement, is increasingly recognized as a reliable predictor of absolute osteoporotic fracture risk. The purpose of this prospective study was to determine the specific independent risk factors for osteoporotic fracture and to predict the 10-yr risk of osteoporotic fracture in the postmenopausal Southern Chinese population. Materials and Methods: A total of 1435 community-dwelling, postmenopausal, treatment-naive women were recruited. Baseline demographic characteristics and clinical risk factors were obtained, and BMD at the spine and hip was measured. Subjects were followed for outcomes of incident low trauma fracture. Ten-year risk of osteoporotic fracture was predicted from the risk factor assessment and BMD measurement by Cox proportional hazards models. Results: The mean age of subjects was 63.4 ± 8.3 yr. After 5.0 ± 2.3 yr (range, 1.0-11.0 yr) of follow-up, 80 nontraumatic new fractures were reported during follow-up. Eight independent clinical risk factors identified at baseline were found to be significant predictors of osteoporotic fracture, with the most important being use of walking aids (RR, 4.2; 95% CI, 2.7-6.7; p < 0.001) and a history of fall (RR, 4.0; 95% CI, 2.5-6.2; p < 0.001). Other predictive factors included being homebound, calcium intake < 400 mg/d, age > 65 yr, history of fracture, and BMI < 19 kg/cm2. Subjects with three to eight clinical risk factors had a predicted 10-year risk of osteoporotic fracture of 25%, which increased to 30% if they also had total hip BMD T-score ≤ -2.5. Conclusions: Clinical risk factor assessment, with or without BMD measurement, is a reliable predictor of 10-year risk of osteoporotic fracture and may be particularly useful in regions or primary care clinics without access to bone densitometry equipment. © 2007 American Society for Bone and Mineral Research.en_US
dc.languageengen_US
dc.publisherAmerican Society for Bone and Mineral Research. The Journal's web site is located at http://www.jbmr.org/view/0/index.htmlen_US
dc.relation.ispartofJournal of Bone and Mineral Researchen_US
dc.subjectChinese-
dc.subjectFracture risk-
dc.subjectOsteoporosis-
dc.subjectWomen-
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBone Density - Physiologyen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDemographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFractures, Bone - Epidemiology - Etiology - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteoporosis, Postmenopausal - Epidemiology - Etiology - Pathologyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTime Factorsen_US
dc.titleTen-year risk of osteoporotic fractures in postmenopausal Chinese women according to clinical risk factors and BMD T-scores: A prospective studyen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.emailTang, G:gwktang@hkucc.hku.hken_US
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.identifier.authorityTang, G=rp00328en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1359/jbmr.070320en_US
dc.identifier.pmid17371165-
dc.identifier.scopuseid_2-s2.0-34548561970en_US
dc.identifier.hkuros131083-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548561970&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue7en_US
dc.identifier.spage1080en_US
dc.identifier.epage1087en_US
dc.identifier.isiWOS:000247451600015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridLee, KK=14629086000en_US
dc.identifier.scopusauthoridHo, AYY=7402675209en_US
dc.identifier.scopusauthoridTang, G=7401633864en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US

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