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Article: Reviews: Therapeutic angiogenesis with bone marrow-derived stem cells

TitleReviews: Therapeutic angiogenesis with bone marrow-derived stem cells
Authors
Issue Date2007
PublisherSage Publications, Inc. The Journal's web site is located at http://cpt.sagepub.com
Citation
Journal Of Cardiovascular Pharmacology And Therapeutics, 2007, v. 12 n. 2, p. 89-97 How to Cite?
AbstractDespite that advances in medical treatment and interventional procedures have reduced the mortality rate in patients with coronary artery disease, the number of patients with refractory myocardial ischemia and congestive heart failure is rapidly increasing. Experimental studies have demonstrated that bone marrow (BM) contains adult stem cells that can induce neovascularization and improve heart function in ischemic myocardium. Recent insights into the understanding of the mechanisms involved in proliferation, recruitment, mobilization, and incorporation of BM-derived stem cells into the myocardium and blood vessels have prompted development of cellular transplantation therapy for heart diseases refractory to conventional therapy. Initial preliminary clinical studies indicated potential clinical benefit of BM therapy in patients with acute myocardial infarction and chronic myocardial ischemia. Nevertheless, many obstacles remain, such as long-term safety and optimal timing and treatment strategies for BM cell therapy, and these issues need to be addressed in rationally designed, randomized clinical trials. © 2007 Sage Publications.
Persistent Identifierhttp://hdl.handle.net/10722/163085
ISSN
2015 Impact Factor: 2.538
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_US
dc.contributor.authorLau, CPen_US
dc.date.accessioned2012-09-05T05:27:24Z-
dc.date.available2012-09-05T05:27:24Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology And Therapeutics, 2007, v. 12 n. 2, p. 89-97en_US
dc.identifier.issn1074-2484en_US
dc.identifier.urihttp://hdl.handle.net/10722/163085-
dc.description.abstractDespite that advances in medical treatment and interventional procedures have reduced the mortality rate in patients with coronary artery disease, the number of patients with refractory myocardial ischemia and congestive heart failure is rapidly increasing. Experimental studies have demonstrated that bone marrow (BM) contains adult stem cells that can induce neovascularization and improve heart function in ischemic myocardium. Recent insights into the understanding of the mechanisms involved in proliferation, recruitment, mobilization, and incorporation of BM-derived stem cells into the myocardium and blood vessels have prompted development of cellular transplantation therapy for heart diseases refractory to conventional therapy. Initial preliminary clinical studies indicated potential clinical benefit of BM therapy in patients with acute myocardial infarction and chronic myocardial ischemia. Nevertheless, many obstacles remain, such as long-term safety and optimal timing and treatment strategies for BM cell therapy, and these issues need to be addressed in rationally designed, randomized clinical trials. © 2007 Sage Publications.en_US
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://cpt.sagepub.comen_US
dc.relation.ispartofJournal of Cardiovascular Pharmacology and Therapeuticsen_US
dc.rightsJournal of Cardiovascular Pharmacology and Therapeutics. Copyright © Sage Publications, Inc.-
dc.subject.meshBone Marrow Cellsen_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshColony-Stimulating Factors - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMyocardial Infarction - Therapyen_US
dc.subject.meshMyocardial Ischemia - Therapyen_US
dc.subject.meshMyocardium - Metabolism - Pathologyen_US
dc.subject.meshNeovascularization, Physiologicen_US
dc.subject.meshStem Cell Transplantationen_US
dc.subject.meshStem Cellsen_US
dc.titleReviews: Therapeutic angiogenesis with bone marrow-derived stem cellsen_US
dc.typeArticleen_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/1074248407303139en_US
dc.identifier.pmid17562779-
dc.identifier.scopuseid_2-s2.0-34249731035en_US
dc.identifier.hkuros126515-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249731035&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.spage89en_US
dc.identifier.epage97en_US
dc.identifier.isiWOS:000247112300002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US
dc.identifier.scopusauthoridLau, CP=7401968501en_US

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