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Article: Polymorphisms of glutathione S-transferase genes and functional activity in smokers with or without COPD

TitlePolymorphisms of glutathione S-transferase genes and functional activity in smokers with or without COPD
Authors
Issue Date2007
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2007, v. 11 n. 5, p. 508-514 How to Cite?
AbstractOBJECTIVE: To determine the role of polymorphisms of genes regulating glutathione S-transferase (GST) and its plasma GST activity in the pathogenesis of chronic obstructive pulmonary disease (COPD). DESIGN: Case-control study. METHODS: One hundred and sixty-three patients with stable COPD from several community or regional hospitals were matched for age and pack-years smoked with the same number of health controls from the general population. Each participant underwent an interview-based respiratory and smoking questionnaire, lung function testing and gave a blood sample. Genotyping was carried out using a polymerase chain reaction-based method for polymorphisms of glutathione S-transferase theta 1 (GSTT1), glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase P 1 (GSTP1) genes. Plasma GST activity was measured using the spectrofluorometric method. RESULTS: There were no significant differences in the distribution of various genotypes of polymorphisms of GSTT1, GSTM1 and GSTP1 between COPD patients and healthy controls. GST activity was significantly higher in patients compared with controls, irrespective of their different genotypes, and was not different between patients with different levels of airflow obstruction. CONCLUSION: Polymorphisms of GSTT1, GSTM1 and GSTP1 genes are unlikely to be involved in the pathogenesis of COPD in Chinese in Hong Kong and Southern China. © 2007 The Union.
Persistent Identifierhttp://hdl.handle.net/10722/163080
ISSN
2015 Impact Factor: 2.148
2015 SCImago Journal Rankings: 1.381
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan-Yeung, Men_US
dc.contributor.authorHo, SPen_US
dc.contributor.authorCheung, AHKen_US
dc.contributor.authorSo, LKYen_US
dc.contributor.authorWong, PCen_US
dc.contributor.authorChan, KKen_US
dc.contributor.authorChan, JWMen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorMak, JCWen_US
dc.date.accessioned2012-09-05T05:27:20Z-
dc.date.available2012-09-05T05:27:20Z-
dc.date.issued2007en_US
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2007, v. 11 n. 5, p. 508-514en_US
dc.identifier.issn1027-3719en_US
dc.identifier.urihttp://hdl.handle.net/10722/163080-
dc.description.abstractOBJECTIVE: To determine the role of polymorphisms of genes regulating glutathione S-transferase (GST) and its plasma GST activity in the pathogenesis of chronic obstructive pulmonary disease (COPD). DESIGN: Case-control study. METHODS: One hundred and sixty-three patients with stable COPD from several community or regional hospitals were matched for age and pack-years smoked with the same number of health controls from the general population. Each participant underwent an interview-based respiratory and smoking questionnaire, lung function testing and gave a blood sample. Genotyping was carried out using a polymerase chain reaction-based method for polymorphisms of glutathione S-transferase theta 1 (GSTT1), glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase P 1 (GSTP1) genes. Plasma GST activity was measured using the spectrofluorometric method. RESULTS: There were no significant differences in the distribution of various genotypes of polymorphisms of GSTT1, GSTM1 and GSTP1 between COPD patients and healthy controls. GST activity was significantly higher in patients compared with controls, irrespective of their different genotypes, and was not different between patients with different levels of airflow obstruction. CONCLUSION: Polymorphisms of GSTT1, GSTM1 and GSTP1 genes are unlikely to be involved in the pathogenesis of COPD in Chinese in Hong Kong and Southern China. © 2007 The Union.en_US
dc.languageengen_US
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_US
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volumeen_US
dc.subject.meshGlutathione Transferase - Physiologyen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshPulmonary Disease, Chronic Obstructive - Enzymology - Ethnology - Geneticsen_US
dc.subject.meshSmoking - Genetics - Metabolismen_US
dc.subject.meshVital Capacityen_US
dc.titlePolymorphisms of glutathione S-transferase genes and functional activity in smokers with or without COPDen_US
dc.typeArticleen_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17439673-
dc.identifier.scopuseid_2-s2.0-34248366522en_US
dc.identifier.hkuros137371-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248366522&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue5en_US
dc.identifier.spage508en_US
dc.identifier.epage514en_US
dc.identifier.isiWOS:000245913500007-
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridChanYeung, M=54790582200en_US
dc.identifier.scopusauthoridHo, SP=12794365900en_US
dc.identifier.scopusauthoridCheung, AHK=12795914100en_US
dc.identifier.scopusauthoridSo, LKY=35985409300en_US
dc.identifier.scopusauthoridWong, PC=7403979916en_US
dc.identifier.scopusauthoridChan, KK=27367456100en_US
dc.identifier.scopusauthoridChan, JWM=34967874700en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.customcontrol.immutablejt 130802-

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