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Article: Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kong
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TitleManganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kong
 
AuthorsHo, JC1
Mak, JCW1
Ho, SP1
Ip, MSM1
Tsang, KW1
Lam, WK1
ChanYeung, M1 1
 
Issue Date2006
 
CitationJournal Of Thoracic Oncology, 2006, v. 1 n. 7, p. 648-653 [How to Cite?]
 
AbstractINTRODUCTION: Antioxidants play an important role in counteracting the effects of potential carcinogens. We investigated the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms and their association with erythrocyte antioxidant activities. PATIENTS AND METHODS: This was a case-control study involving patients with confirmed lung cancer and age-matched healthy controls. Genotyping of MnSOD and catalase in DNA extracted from peripheral white cells was performed by polymerase chain reaction-based restriction fragment length polymorphism. Erythrocyte superoxide dismutase and catalase activities were measured spectrophotometrically using chemical kinetic reactions. RESULTS: We recruited 240 patients with lung cancer (63% male, aged 55.6 ± 11.9 years, 58% adenocarcinoma, 85% clinical stage III or IV) and 240 age-matched healthy controls. The frequencies of the Val allele of MnSOD gene and the C allele of catalase gene were common (>86% and 90%, respectively), with similar distribution, in both patients with lung cancer and controls. The homozygous variant genotypes of MnSOD and catalase were not associated with increased lung cancer risk. The erythrocyte SOD and catalase activity was significantly lower among all patients with lung cancer as a whole compared with controls, irrespective of genotypes. However, patients with adenocarcinoma and non-adenocarcinoma showed differences in SOD and catalase activity among different genotypes in comparison with controls. CONCLUSION: The common Val16Ala MnSOD polymorphism and C-T substitution in the promoter region of the catalase gene do not confer increased or reduced risk of lung cancer in Chinese in Hong Kong. © 2006International Association for the Study of Lung Cancer.
 
ISSN1556-0864
2012 Impact Factor: 4.473
2012 SCImago Journal Rankings: 1.766
 
ISI Accession Number IDWOS:000240664700008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, JC
 
dc.contributor.authorMak, JCW
 
dc.contributor.authorHo, SP
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorTsang, KW
 
dc.contributor.authorLam, WK
 
dc.contributor.authorChanYeung, M
 
dc.date.accessioned2012-09-05T05:27:17Z
 
dc.date.available2012-09-05T05:27:17Z
 
dc.date.issued2006
 
dc.description.abstractINTRODUCTION: Antioxidants play an important role in counteracting the effects of potential carcinogens. We investigated the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms and their association with erythrocyte antioxidant activities. PATIENTS AND METHODS: This was a case-control study involving patients with confirmed lung cancer and age-matched healthy controls. Genotyping of MnSOD and catalase in DNA extracted from peripheral white cells was performed by polymerase chain reaction-based restriction fragment length polymorphism. Erythrocyte superoxide dismutase and catalase activities were measured spectrophotometrically using chemical kinetic reactions. RESULTS: We recruited 240 patients with lung cancer (63% male, aged 55.6 ± 11.9 years, 58% adenocarcinoma, 85% clinical stage III or IV) and 240 age-matched healthy controls. The frequencies of the Val allele of MnSOD gene and the C allele of catalase gene were common (>86% and 90%, respectively), with similar distribution, in both patients with lung cancer and controls. The homozygous variant genotypes of MnSOD and catalase were not associated with increased lung cancer risk. The erythrocyte SOD and catalase activity was significantly lower among all patients with lung cancer as a whole compared with controls, irrespective of genotypes. However, patients with adenocarcinoma and non-adenocarcinoma showed differences in SOD and catalase activity among different genotypes in comparison with controls. CONCLUSION: The common Val16Ala MnSOD polymorphism and C-T substitution in the promoter region of the catalase gene do not confer increased or reduced risk of lung cancer in Chinese in Hong Kong. © 2006International Association for the Study of Lung Cancer.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Thoracic Oncology, 2006, v. 1 n. 7, p. 648-653 [How to Cite?]
 
dc.identifier.epage653
 
dc.identifier.hkuros130185
 
dc.identifier.isiWOS:000240664700008
 
dc.identifier.issn1556-0864
2012 Impact Factor: 4.473
2012 SCImago Journal Rankings: 1.766
 
dc.identifier.issue7
 
dc.identifier.pmid17409931
 
dc.identifier.scopuseid_2-s2.0-34247895664
 
dc.identifier.spage648
 
dc.identifier.urihttp://hdl.handle.net/10722/163075
 
dc.identifier.volume1
 
dc.languageeng
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Thoracic Oncology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Thoracic Oncology. Copyright © Lippincott Williams & Wilkins.
 
dc.subject.meshAdenocarcinoma - Ethnology - Genetics
 
dc.subject.meshAmino Acid Substitution
 
dc.subject.meshAsian Continental Ancestry Group - Genetics
 
dc.subject.meshCatalase - Genetics - Metabolism
 
dc.subject.meshFemale
 
dc.subject.meshGene Frequency
 
dc.subject.meshGenetic Predisposition To Disease - Ethnology
 
dc.subject.meshGenotype
 
dc.subject.meshHumans
 
dc.subject.meshLung Neoplasms - Enzymology - Ethnology - Genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Genetic
 
dc.subject.meshSuperoxide Dismutase - Blood - Genetics - Metabolism
 
dc.titleManganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kong
 
dc.typeArticle
 
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<description.abstract>INTRODUCTION: Antioxidants play an important role in counteracting the effects of potential carcinogens. We investigated the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms and their association with erythrocyte antioxidant activities. PATIENTS AND METHODS: This was a case-control study involving patients with confirmed lung cancer and age-matched healthy controls. Genotyping of MnSOD and catalase in DNA extracted from peripheral white cells was performed by polymerase chain reaction-based restriction fragment length polymorphism. Erythrocyte superoxide dismutase and catalase activities were measured spectrophotometrically using chemical kinetic reactions. RESULTS: We recruited 240 patients with lung cancer (63% male, aged 55.6 &#177; 11.9 years, 58% adenocarcinoma, 85% clinical stage III or IV) and 240 age-matched healthy controls. The frequencies of the Val allele of MnSOD gene and the C allele of catalase gene were common (&gt;86% and 90%, respectively), with similar distribution, in both patients with lung cancer and controls. The homozygous variant genotypes of MnSOD and catalase were not associated with increased lung cancer risk. The erythrocyte SOD and catalase activity was significantly lower among all patients with lung cancer as a whole compared with controls, irrespective of genotypes. However, patients with adenocarcinoma and non-adenocarcinoma showed differences in SOD and catalase activity among different genotypes in comparison with controls. CONCLUSION: The common Val16Ala MnSOD polymorphism and C-T substitution in the promoter region of the catalase gene do not confer increased or reduced risk of lung cancer in Chinese in Hong Kong. &#169; 2006International Association for the Study of Lung Cancer.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong