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Article: Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kong

TitleManganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kong
Authors
Issue Date2006
Citation
Journal Of Thoracic Oncology, 2006, v. 1 n. 7, p. 648-653 How to Cite?
AbstractINTRODUCTION: Antioxidants play an important role in counteracting the effects of potential carcinogens. We investigated the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms and their association with erythrocyte antioxidant activities. PATIENTS AND METHODS: This was a case-control study involving patients with confirmed lung cancer and age-matched healthy controls. Genotyping of MnSOD and catalase in DNA extracted from peripheral white cells was performed by polymerase chain reaction-based restriction fragment length polymorphism. Erythrocyte superoxide dismutase and catalase activities were measured spectrophotometrically using chemical kinetic reactions. RESULTS: We recruited 240 patients with lung cancer (63% male, aged 55.6 ± 11.9 years, 58% adenocarcinoma, 85% clinical stage III or IV) and 240 age-matched healthy controls. The frequencies of the Val allele of MnSOD gene and the C allele of catalase gene were common (>86% and 90%, respectively), with similar distribution, in both patients with lung cancer and controls. The homozygous variant genotypes of MnSOD and catalase were not associated with increased lung cancer risk. The erythrocyte SOD and catalase activity was significantly lower among all patients with lung cancer as a whole compared with controls, irrespective of genotypes. However, patients with adenocarcinoma and non-adenocarcinoma showed differences in SOD and catalase activity among different genotypes in comparison with controls. CONCLUSION: The common Val16Ala MnSOD polymorphism and C-T substitution in the promoter region of the catalase gene do not confer increased or reduced risk of lung cancer in Chinese in Hong Kong. © 2006International Association for the Study of Lung Cancer.
Persistent Identifierhttp://hdl.handle.net/10722/163075
ISSN
2014 Impact Factor: 5.282
2014 SCImago Journal Rankings: 2.436
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, JCen_US
dc.contributor.authorMak, JCWen_US
dc.contributor.authorHo, SPen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorTsang, KWen_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorChanYeung, Men_US
dc.date.accessioned2012-09-05T05:27:17Z-
dc.date.available2012-09-05T05:27:17Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Thoracic Oncology, 2006, v. 1 n. 7, p. 648-653en_US
dc.identifier.issn1556-0864en_US
dc.identifier.urihttp://hdl.handle.net/10722/163075-
dc.description.abstractINTRODUCTION: Antioxidants play an important role in counteracting the effects of potential carcinogens. We investigated the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms and their association with erythrocyte antioxidant activities. PATIENTS AND METHODS: This was a case-control study involving patients with confirmed lung cancer and age-matched healthy controls. Genotyping of MnSOD and catalase in DNA extracted from peripheral white cells was performed by polymerase chain reaction-based restriction fragment length polymorphism. Erythrocyte superoxide dismutase and catalase activities were measured spectrophotometrically using chemical kinetic reactions. RESULTS: We recruited 240 patients with lung cancer (63% male, aged 55.6 ± 11.9 years, 58% adenocarcinoma, 85% clinical stage III or IV) and 240 age-matched healthy controls. The frequencies of the Val allele of MnSOD gene and the C allele of catalase gene were common (>86% and 90%, respectively), with similar distribution, in both patients with lung cancer and controls. The homozygous variant genotypes of MnSOD and catalase were not associated with increased lung cancer risk. The erythrocyte SOD and catalase activity was significantly lower among all patients with lung cancer as a whole compared with controls, irrespective of genotypes. However, patients with adenocarcinoma and non-adenocarcinoma showed differences in SOD and catalase activity among different genotypes in comparison with controls. CONCLUSION: The common Val16Ala MnSOD polymorphism and C-T substitution in the promoter region of the catalase gene do not confer increased or reduced risk of lung cancer in Chinese in Hong Kong. © 2006International Association for the Study of Lung Cancer.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Thoracic Oncologyen_US
dc.rightsJournal of Thoracic Oncology. Copyright © Lippincott Williams & Wilkins.-
dc.subject.meshAdenocarcinoma - Ethnology - Geneticsen_US
dc.subject.meshAmino Acid Substitutionen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCatalase - Genetics - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Disease - Ethnologyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLung Neoplasms - Enzymology - Ethnology - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshSuperoxide Dismutase - Blood - Genetics - Metabolismen_US
dc.titleManganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailHo, JC:jhocm@hku.hken_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.authorityHo, JC=rp00258en_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17409931-
dc.identifier.scopuseid_2-s2.0-34247895664en_US
dc.identifier.hkuros130185-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247895664&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1en_US
dc.identifier.issue7en_US
dc.identifier.spage648en_US
dc.identifier.epage653en_US
dc.identifier.isiWOS:000240664700008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, JC=7402649981en_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridHo, SP=12794365900en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridTsang, KW=24296730400en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridChanYeung, M=54790582200en_US

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