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Article: An inverse correlation between interleukin-6 and select gene promoter methylation in patients with gastric cancer

TitleAn inverse correlation between interleukin-6 and select gene promoter methylation in patients with gastric cancer
Authors
KeywordsCpG island methylator phenotype
DNA methylation
Gastric tumor
Interleukin-6
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 2006, v. 74 n. 2, p. 85-90 How to Cite?
AbstractBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer. Copyright © 2006 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/163059
ISSN
2015 Impact Factor: 1.884
2015 SCImago Journal Rankings: 0.953
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, LPen_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorHuang, Cen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorRashid, Aen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorChan, AOOen_HK
dc.date.accessioned2012-09-05T05:27:05Z-
dc.date.available2012-09-05T05:27:05Z-
dc.date.issued2006en_HK
dc.identifier.citationDigestion, 2006, v. 74 n. 2, p. 85-90en_HK
dc.identifier.issn0012-2823en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163059-
dc.description.abstractBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer. Copyright © 2006 S. Karger AG.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIGen_HK
dc.relation.ispartofDigestionen_HK
dc.rightsDigestion. Copyright © S Karger AG.-
dc.subjectCpG island methylator phenotypeen_HK
dc.subjectDNA methylationen_HK
dc.subjectGastric tumoren_HK
dc.subjectInterleukin-6en_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshApoptosis Regulatory Proteins - Geneticsen_US
dc.subject.meshCadherins - Geneticsen_US
dc.subject.meshCalcium-Calmodulin-Dependent Protein Kinases - Geneticsen_US
dc.subject.meshCpg Islands - Geneticsen_US
dc.subject.meshDna Methylationen_US
dc.subject.meshDna Modification Methylasesen_US
dc.subject.meshDna Repair Enzymesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshGenes, P16en_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-6 - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPrognosisen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshStomach Neoplasms - Diagnosis - Mortality - Pathologyen_US
dc.subject.meshTumor Suppressor Protein P14arf - Geneticsen_US
dc.subject.meshTumor Suppressor Proteinsen_US
dc.titleAn inverse correlation between interleukin-6 and select gene promoter methylation in patients with gastric canceren_HK
dc.typeArticleen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000097623en_HK
dc.identifier.pmid17139167-
dc.identifier.scopuseid_2-s2.0-33846652476en_HK
dc.identifier.hkuros125306-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846652476&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue2en_HK
dc.identifier.spage85en_HK
dc.identifier.epage90en_HK
dc.identifier.isiWOS:000243564500003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridTang, LP=15837972900en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK
dc.identifier.scopusauthoridHui, WM=7103196477en_HK
dc.identifier.scopusauthoridHuang, C=15837017600en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridRashid, A=7102299914en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK

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