Article: Efficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre

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TitleEfficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre
AuthorsOn Chan, AO1
Mo Hui, W1
Leung, G1
Hu, WHC1
Lam, SK1
Wong, BCY1
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
CitationAlimentary Pharmacology And Therapeutics, 2007, v. 25 n. 4, p. 463-469 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
AbstractBackground: Tegaserod has been shown to be effective in chronic constipation in Western population. Aim: We investigated if tegaserod is equally effective in Chinese population. Materials and methods: Two hundred and fifty patients were randomized to a double-blinded 8-week treatment of tegaserod 6 mg b.d. or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowel motion ≥1/week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: One hundred and nine patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs. 29% for the treatment and placebo groups (P = 0.005). The sustained complete spontaneous bowel motion rate was 29.4% vs. 15.7% in the two groups (P = 0.016). The response rates were higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating and satisfaction of bowel habit (P < 0.05). The mental score was higher in the treatment group (46.8 ± 9 vs. 43.6 ± 10, P = 0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in Western population. © 2007 The Authors.
ISSN0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
DOIhttp://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorOn Chan, AO
dc.contributor.authorMo Hui, W
dc.contributor.authorLeung, G
dc.contributor.authorHu, WHC
dc.contributor.authorLam, SK
dc.contributor.authorWong, BCY
dc.date.accessioned2012-09-05T05:27:03Z
dc.date.available2012-09-05T05:27:03Z
dc.date.issued2007
dc.description.abstractBackground: Tegaserod has been shown to be effective in chronic constipation in Western population. Aim: We investigated if tegaserod is equally effective in Chinese population. Materials and methods: Two hundred and fifty patients were randomized to a double-blinded 8-week treatment of tegaserod 6 mg b.d. or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowel motion ≥1/week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: One hundred and nine patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs. 29% for the treatment and placebo groups (P = 0.005). The sustained complete spontaneous bowel motion rate was 29.4% vs. 15.7% in the two groups (P = 0.016). The response rates were higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating and satisfaction of bowel habit (P < 0.05). The mental score was higher in the treatment group (46.8 ± 9 vs. 43.6 ± 10, P = 0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in Western population. © 2007 The Authors.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2007, v. 25 n. 4, p. 463-469 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
dc.identifier.citeulike1081022
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
dc.identifier.epage469
dc.identifier.hkuros131406
dc.identifier.isiWOS:000243866400013
dc.identifier.issn0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
dc.identifier.issue4
dc.identifier.pmid17270002
dc.identifier.scopuseid_2-s2.0-33846587919
dc.identifier.spage463
dc.identifier.urihttp://hdl.handle.net/10722/163057
dc.identifier.volume25
dc.languageeng
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
dc.publisher.placeUnited Kingdom
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
dc.relation.referencesReferences in Scopus
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
dc.subject.meshAdult
dc.subject.meshChina
dc.subject.meshChronic Disease
dc.subject.meshConstipation - Drug Therapy
dc.subject.meshDouble-Blind Method
dc.subject.meshFemale
dc.subject.meshGastrointestinal Agents - Therapeutic Use
dc.subject.meshHumans
dc.subject.meshIndoles - Therapeutic Use
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshTreatment Outcome
dc.titleEfficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong