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Article: Efficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre
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TitleEfficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre
 
AuthorsOn Chan, AO1
Mo Hui, W1
Leung, G1
Hu, WHC1
Lam, SK1
Wong, BCY1
 
Issue Date2007
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
CitationAlimentary Pharmacology And Therapeutics, 2007, v. 25 n. 4, p. 463-469 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
 
AbstractBackground: Tegaserod has been shown to be effective in chronic constipation in Western population. Aim: We investigated if tegaserod is equally effective in Chinese population. Materials and methods: Two hundred and fifty patients were randomized to a double-blinded 8-week treatment of tegaserod 6 mg b.d. or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowel motion ≥1/week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: One hundred and nine patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs. 29% for the treatment and placebo groups (P = 0.005). The sustained complete spontaneous bowel motion rate was 29.4% vs. 15.7% in the two groups (P = 0.016). The response rates were higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating and satisfaction of bowel habit (P < 0.05). The mental score was higher in the treatment group (46.8 ± 9 vs. 43.6 ± 10, P = 0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in Western population. © 2007 The Authors.
 
ISSN0269-2813
2013 Impact Factor: 5.478
2013 SCImago Journal Rankings: 2.609
 
DOIhttp://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
 
ISI Accession Number IDWOS:000243866400013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOn Chan, AO
 
dc.contributor.authorMo Hui, W
 
dc.contributor.authorLeung, G
 
dc.contributor.authorHu, WHC
 
dc.contributor.authorLam, SK
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2012-09-05T05:27:03Z
 
dc.date.available2012-09-05T05:27:03Z
 
dc.date.issued2007
 
dc.description.abstractBackground: Tegaserod has been shown to be effective in chronic constipation in Western population. Aim: We investigated if tegaserod is equally effective in Chinese population. Materials and methods: Two hundred and fifty patients were randomized to a double-blinded 8-week treatment of tegaserod 6 mg b.d. or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowel motion ≥1/week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: One hundred and nine patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs. 29% for the treatment and placebo groups (P = 0.005). The sustained complete spontaneous bowel motion rate was 29.4% vs. 15.7% in the two groups (P = 0.016). The response rates were higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating and satisfaction of bowel habit (P < 0.05). The mental score was higher in the treatment group (46.8 ± 9 vs. 43.6 ± 10, P = 0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in Western population. © 2007 The Authors.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2007, v. 25 n. 4, p. 463-469 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
 
dc.identifier.citeulike1081022
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2036.2006.03230.x
 
dc.identifier.epage469
 
dc.identifier.hkuros131406
 
dc.identifier.isiWOS:000243866400013
 
dc.identifier.issn0269-2813
2013 Impact Factor: 5.478
2013 SCImago Journal Rankings: 2.609
 
dc.identifier.issue4
 
dc.identifier.pmid17270002
 
dc.identifier.scopuseid_2-s2.0-33846587919
 
dc.identifier.spage463
 
dc.identifier.urihttp://hdl.handle.net/10722/163057
 
dc.identifier.volume25
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
 
dc.subject.meshAdult
 
dc.subject.meshChina
 
dc.subject.meshChronic Disease
 
dc.subject.meshConstipation - Drug Therapy
 
dc.subject.meshDouble-Blind Method
 
dc.subject.meshFemale
 
dc.subject.meshGastrointestinal Agents - Therapeutic Use
 
dc.subject.meshHumans
 
dc.subject.meshIndoles - Therapeutic Use
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshTreatment Outcome
 
dc.titleEfficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre
 
dc.typeArticle
 
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<contributor.author>Hu, WHC</contributor.author>
<contributor.author>Lam, SK</contributor.author>
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<description.abstract>Background: Tegaserod has been shown to be effective in chronic constipation in Western population. Aim: We investigated if tegaserod is equally effective in Chinese population. Materials and methods: Two hundred and fifty patients were randomized to a double-blinded 8-week treatment of tegaserod 6 mg b.d. or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowel motion &#8805;1/week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: One hundred and nine patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs. 29% for the treatment and placebo groups (P = 0.005). The sustained complete spontaneous bowel motion rate was 29.4% vs. 15.7% in the two groups (P = 0.016). The response rates were higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating and satisfaction of bowel habit (P &lt; 0.05). The mental score was higher in the treatment group (46.8 &#177; 9 vs. 43.6 &#177; 10, P = 0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in Western population. &#169; 2007 The Authors.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong