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Article: Efficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre

TitleEfficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centre
Authors
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2007, v. 25 n. 4, p. 463-469 How to Cite?
Abstract
Background: Tegaserod has been shown to be effective in chronic constipation in Western population. Aim: We investigated if tegaserod is equally effective in Chinese population. Materials and methods: Two hundred and fifty patients were randomized to a double-blinded 8-week treatment of tegaserod 6 mg b.d. or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowel motion ≥1/week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: One hundred and nine patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs. 29% for the treatment and placebo groups (P = 0.005). The sustained complete spontaneous bowel motion rate was 29.4% vs. 15.7% in the two groups (P = 0.016). The response rates were higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating and satisfaction of bowel habit (P < 0.05). The mental score was higher in the treatment group (46.8 ± 9 vs. 43.6 ± 10, P = 0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in Western population. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/163057
ISSN
2013 Impact Factor: 5.478
2013 SCImago Journal Rankings: 2.609
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOn Chan, AOen_US
dc.contributor.authorMo Hui, Wen_US
dc.contributor.authorLeung, Gen_US
dc.contributor.authorHu, WHCen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorWong, BCYen_US
dc.date.accessioned2012-09-05T05:27:03Z-
dc.date.available2012-09-05T05:27:03Z-
dc.date.issued2007en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2007, v. 25 n. 4, p. 463-469en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/163057-
dc.description.abstractBackground: Tegaserod has been shown to be effective in chronic constipation in Western population. Aim: We investigated if tegaserod is equally effective in Chinese population. Materials and methods: Two hundred and fifty patients were randomized to a double-blinded 8-week treatment of tegaserod 6 mg b.d. or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowel motion ≥1/week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: One hundred and nine patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs. 29% for the treatment and placebo groups (P = 0.005). The sustained complete spontaneous bowel motion rate was 29.4% vs. 15.7% in the two groups (P = 0.016). The response rates were higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating and satisfaction of bowel habit (P < 0.05). The mental score was higher in the treatment group (46.8 ± 9 vs. 43.6 ± 10, P = 0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in Western population. © 2007 The Authors.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdulten_US
dc.subject.meshChinaen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshConstipation - Drug Therapyen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Agents - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshIndoles - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEfficacy of tegaserod for functional constipation in Chinese subjects: A randomized double-blind controlled trial in a single centreen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2036.2006.03230.xen_US
dc.identifier.pmid17270002en_US
dc.identifier.scopuseid_2-s2.0-33846587919en_US
dc.identifier.hkuros131406-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846587919&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue4en_US
dc.identifier.spage463en_US
dc.identifier.epage469en_US
dc.identifier.isiWOS:000243866400013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridOn Chan, AO=7403167965en_US
dc.identifier.scopusauthoridMo Hui, W=15835225200en_US
dc.identifier.scopusauthoridLeung, G=35964341400en_US
dc.identifier.scopusauthoridHu, WHC=25932937100en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.citeulike1081022-

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