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Article: Proton-pump inhibitor failure/resistance: Proposed mechanisms and therapeutic algorithm

TitleProton-pump inhibitor failure/resistance: Proposed mechanisms and therapeutic algorithm
Authors
KeywordsEsophagus
Gastroesophageal Reflux
Proton Pump Inhibitor
Issue Date2006
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2006, v. 21 SUPPL. 5, p. S119-S124 How to Cite?
AbstractProton-pump inhibitor (PPI) failure has become more prevalent with the increasing use of PPI as the first-line agent in the treatment of gastroesophageal reflux disease (GERD). The underlying mechanisms are diverse and may overlap. The commonly available investigations are limited in their capacity in identifying the underlying cause for PPI failure. Multichannel intraluminal impedance with 24-h pH sensors may be useful to identify non-acid or duodenogastroesophageal reflux in selected cases. The management strategy for PPI failure is largely empirical. Patients who have symptomatic failure on normal dose of PPI shall try double dose PPI. Failing that, empirical treatment with transient lower esophageal sphincter relaxation reducers or pain modulators can be tried. Better understanding of the pathophysiology and mechanisms for PPI failure will help to improve the management of this rising problem. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/163041
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, TKen_US
dc.contributor.authorWong, BCYen_US
dc.date.accessioned2012-09-05T05:26:54Z-
dc.date.available2012-09-05T05:26:54Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2006, v. 21 SUPPL. 5, p. S119-S124en_US
dc.identifier.issn0815-9319en_US
dc.identifier.urihttp://hdl.handle.net/10722/163041-
dc.description.abstractProton-pump inhibitor (PPI) failure has become more prevalent with the increasing use of PPI as the first-line agent in the treatment of gastroesophageal reflux disease (GERD). The underlying mechanisms are diverse and may overlap. The commonly available investigations are limited in their capacity in identifying the underlying cause for PPI failure. Multichannel intraluminal impedance with 24-h pH sensors may be useful to identify non-acid or duodenogastroesophageal reflux in selected cases. The management strategy for PPI failure is largely empirical. Patients who have symptomatic failure on normal dose of PPI shall try double dose PPI. Failing that, empirical treatment with transient lower esophageal sphincter relaxation reducers or pain modulators can be tried. Better understanding of the pathophysiology and mechanisms for PPI failure will help to improve the management of this rising problem. © 2006 The Authors.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_US
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_US
dc.subjectEsophagusen_US
dc.subjectGastroesophageal Refluxen_US
dc.subjectProton Pump Inhibitoren_US
dc.titleProton-pump inhibitor failure/resistance: Proposed mechanisms and therapeutic algorithmen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1746.2006.04716.xen_US
dc.identifier.scopuseid_2-s2.0-33750917083en_US
dc.identifier.hkuros131403-
dc.identifier.hkuros130233-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750917083&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issueSUPPL. 5en_US
dc.identifier.spageS119en_US
dc.identifier.epageS124en_US
dc.identifier.isiWOS:000243006100004-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridCheung, TK=7103334158en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US

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