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Article: Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J 2 through the downregulation of angiopoietin-1

TitleInhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J 2 through the downregulation of angiopoietin-1
Authors
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2006, v. 243 n. 2, p. 246-254 How to Cite?
AbstractPeroxisome proliferator-activated receptor gamma (PPARγ) ligands have been shown to inhibit angiogenesis. We showed that treatment with 15d-PGJ 2, a PPARγ ligand, downregulate the expressions of angiopoietin-1 (Ang-1) in gastric cancer cells MKN45. The medium of MKN45 cells treated with 15d-PGJ 2 significantly inhibited the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, Matrigel plug assay revealed that 15d-PGJ 2 reduced in vivo angiogenesis induced by MKN45 cells. These modulations were restored by the addition of recombinant Ang-1. Our findings supported that 15d-PGJ 2 suppressed angiogenesis of gastric cancer cells by downregulation of Ang-1. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163030
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, YGen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorWu, KCen_US
dc.contributor.authorBai, AHCen_US
dc.contributor.authorChan, MCWen_US
dc.contributor.authorYu, Jen_US
dc.contributor.authorFan, DMen_US
dc.contributor.authorLeung, WKen_US
dc.date.accessioned2012-09-05T05:26:48Z-
dc.date.available2012-09-05T05:26:48Z-
dc.date.issued2006en_US
dc.identifier.citationCancer Letters, 2006, v. 243 n. 2, p. 246-254en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/163030-
dc.description.abstractPeroxisome proliferator-activated receptor gamma (PPARγ) ligands have been shown to inhibit angiogenesis. We showed that treatment with 15d-PGJ 2, a PPARγ ligand, downregulate the expressions of angiopoietin-1 (Ang-1) in gastric cancer cells MKN45. The medium of MKN45 cells treated with 15d-PGJ 2 significantly inhibited the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, Matrigel plug assay revealed that 15d-PGJ 2 reduced in vivo angiogenesis induced by MKN45 cells. These modulations were restored by the addition of recombinant Ang-1. Our findings supported that 15d-PGJ 2 suppressed angiogenesis of gastric cancer cells by downregulation of Ang-1. © 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshAngiogenesis Inhibitors - Pharmacologyen_US
dc.subject.meshAngiopoietin-1 - Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDown-Regulation - Drug Effects - Geneticsen_US
dc.subject.meshEndothelial Cells - Cytology - Drug Effects - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshNeovascularization, Pathologic - Genetics - Metabolism - Prevention & Controlen_US
dc.subject.meshNeovascularization, Physiologic - Drug Effectsen_US
dc.subject.meshOligonucleotide Array Sequence Analysisen_US
dc.subject.meshProstaglandin D2 - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshStomach Neoplasms - Blood Supply - Pathologyen_US
dc.subject.meshVascular Endothelial Growth Factor A - Metabolismen_US
dc.titleInhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J 2 through the downregulation of angiopoietin-1en_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2005.11.039en_US
dc.identifier.pmid16412567-
dc.identifier.scopuseid_2-s2.0-33749240167en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749240167&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume243en_US
dc.identifier.issue2en_US
dc.identifier.spage246en_US
dc.identifier.epage254en_US
dc.identifier.isiWOS:000242481900010-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridFu, YG=8599738000en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridWu, KC=8947728400en_US
dc.identifier.scopusauthoridBai, AHC=7006523130en_US
dc.identifier.scopusauthoridChan, MCW=36941299700en_US
dc.identifier.scopusauthoridYu, J=35351306800en_US
dc.identifier.scopusauthoridFan, DM=7202965595en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US

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