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Article: Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J 2 through the downregulation of angiopoietin-1

TitleInhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J 2 through the downregulation of angiopoietin-1
Authors
Fu, YGSung, JJYWu, KCBai, AHCChan, MCWYu, JFan, DMLeung, WK
KeywordsAngiogenesis
Angiopoietin
Gastric cancer
Peroxisome proliferators activated receptor
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2006, v. 243 n. 2, p. 246-254 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2005.11.039
AbstractPeroxisome proliferator-activated receptor gamma (PPARγ) ligands have been shown to inhibit angiogenesis. We showed that treatment with 15d-PGJ 2, a PPARγ ligand, downregulate the expressions of angiopoietin-1 (Ang-1) in gastric cancer cells MKN45. The medium of MKN45 cells treated with 15d-PGJ 2 significantly inhibited the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, Matrigel plug assay revealed that 15d-PGJ 2 reduced in vivo angiogenesis induced by MKN45 cells. These modulations were restored by the addition of recombinant Ang-1. Our findings supported that 15d-PGJ 2 suppressed angiogenesis of gastric cancer cells by downregulation of Ang-1. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163030
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000242481900010
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorFu, YGen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorWu, KCen_US
dc.contributor.authorBai, AHCen_US
dc.contributor.authorChan, MCWen_US
dc.contributor.authorYu, Jen_US
dc.contributor.authorFan, DMen_US
dc.contributor.authorLeung, WKen_US
dc.date.accessioned2012-09-05T05:26:48Z-
dc.date.available2012-09-05T05:26:48Z-
dc.date.issued2006en_US
dc.identifier.citationCancer Letters, 2006, v. 243 n. 2, p. 246-254en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/163030-
dc.description.abstractPeroxisome proliferator-activated receptor gamma (PPARγ) ligands have been shown to inhibit angiogenesis. We showed that treatment with 15d-PGJ 2, a PPARγ ligand, downregulate the expressions of angiopoietin-1 (Ang-1) in gastric cancer cells MKN45. The medium of MKN45 cells treated with 15d-PGJ 2 significantly inhibited the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, Matrigel plug assay revealed that 15d-PGJ 2 reduced in vivo angiogenesis induced by MKN45 cells. These modulations were restored by the addition of recombinant Ang-1. Our findings supported that 15d-PGJ 2 suppressed angiogenesis of gastric cancer cells by downregulation of Ang-1. © 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subjectAngiogenesis-
dc.subjectAngiopoietin-
dc.subjectGastric cancer-
dc.subjectPeroxisome proliferators activated receptor-
dc.subject.meshAngiogenesis Inhibitors - Pharmacologyen_US
dc.subject.meshAngiopoietin-1 - Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDown-Regulation - Drug Effects - Geneticsen_US
dc.subject.meshEndothelial Cells - Cytology - Drug Effects - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshNeovascularization, Pathologic - Genetics - Metabolism - Prevention & Controlen_US
dc.subject.meshNeovascularization, Physiologic - Drug Effectsen_US
dc.subject.meshOligonucleotide Array Sequence Analysisen_US
dc.subject.meshProstaglandin D2 - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshStomach Neoplasms - Blood Supply - Pathologyen_US
dc.subject.meshVascular Endothelial Growth Factor A - Metabolismen_US
dc.titleInhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J 2 through the downregulation of angiopoietin-1en_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2005.11.039en_US
dc.identifier.pmid16412567-
dc.identifier.scopuseid_2-s2.0-33749240167en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749240167&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume243en_US
dc.identifier.issue2en_US
dc.identifier.spage246en_US
dc.identifier.epage254en_US
dc.identifier.isiWOS:000242481900010-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridFu, YG=8599738000en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridWu, KC=8947728400en_US
dc.identifier.scopusauthoridBai, AHC=7006523130en_US
dc.identifier.scopusauthoridChan, MCW=36941299700en_US
dc.identifier.scopusauthoridYu, J=35351306800en_US
dc.identifier.scopusauthoridFan, DM=7202965595en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.issnl0304-3835-

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