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Article: Repair of infarcted myocardium by an extract of Geum japonicum with dual effects on angiogenesis and myogenesis

TitleRepair of infarcted myocardium by an extract of Geum japonicum with dual effects on angiogenesis and myogenesis
Authors
Issue Date2006
PublisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
Citation
Clinical Chemistry, 2006, v. 52 n. 8, p. 1460-1468 How to Cite?
AbstractBackground: It has become apparent recently that cardiac myocytes can divide after myocardial infarction, a circumstance that challenges the orthodox view that myocytes may be terminally differentiated. Replacement of the necrosed heart tissue by newly regenerated functional myocardium is a therapeutic ideal, but attempts to reconstitute functional myocardia and coronary vessels have been less successful. Methods: We isolated a fraction containing 5 compounds from the Chinese herb Geum japonicum, which stimulates the processes of angiogenesis and cardiomyogenesis. We investigated these dual properties in both ex vivo and in vivo systems. Results: We observed that this bioactive fraction displayed favorable dual actions on early angiogenesis and cardiomyogenesis in acute myocardial infarction in an animal model. Our results demonstrated that application of this bioactive fraction showed pronounced effects on limiting infarct size by 35%-45%, stimulating early development of new blood vessels in 24 h, and regenerating myocardium, replacing ∼49% of the total infarction volume after 2 weeks. Echocardiographic studies demonstrated marked improvement of left ventricular function within 2 days after infarction, and the improvement was sustained for >1 month. Conclusions: The properties of this bioactive fraction appear to be entirely novel and represent a new approach for the treatment of ischemic heart disease. © 2006 American Association for Clinical Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/163006
ISSN
2015 Impact Factor: 7.457
2015 SCImago Journal Rankings: 2.472
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Men_US
dc.contributor.authorYu, CMen_US
dc.contributor.authorCheng, Len_US
dc.contributor.authorWang, Men_US
dc.contributor.authorGu, Xen_US
dc.contributor.authorLee, KHen_US
dc.contributor.authorWang, Ten_US
dc.contributor.authorSung, YTen_US
dc.contributor.authorSanderson, JEen_US
dc.date.accessioned2012-09-05T05:26:28Z-
dc.date.available2012-09-05T05:26:28Z-
dc.date.issued2006en_US
dc.identifier.citationClinical Chemistry, 2006, v. 52 n. 8, p. 1460-1468en_US
dc.identifier.issn0009-9147en_US
dc.identifier.urihttp://hdl.handle.net/10722/163006-
dc.description.abstractBackground: It has become apparent recently that cardiac myocytes can divide after myocardial infarction, a circumstance that challenges the orthodox view that myocytes may be terminally differentiated. Replacement of the necrosed heart tissue by newly regenerated functional myocardium is a therapeutic ideal, but attempts to reconstitute functional myocardia and coronary vessels have been less successful. Methods: We isolated a fraction containing 5 compounds from the Chinese herb Geum japonicum, which stimulates the processes of angiogenesis and cardiomyogenesis. We investigated these dual properties in both ex vivo and in vivo systems. Results: We observed that this bioactive fraction displayed favorable dual actions on early angiogenesis and cardiomyogenesis in acute myocardial infarction in an animal model. Our results demonstrated that application of this bioactive fraction showed pronounced effects on limiting infarct size by 35%-45%, stimulating early development of new blood vessels in 24 h, and regenerating myocardium, replacing ∼49% of the total infarction volume after 2 weeks. Echocardiographic studies demonstrated marked improvement of left ventricular function within 2 days after infarction, and the improvement was sustained for >1 month. Conclusions: The properties of this bioactive fraction appear to be entirely novel and represent a new approach for the treatment of ischemic heart disease. © 2006 American Association for Clinical Chemistry.en_US
dc.languageengen_US
dc.publisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.orgen_US
dc.relation.ispartofClinical Chemistryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrugs, Chinese Herbal - Therapeutic Useen_US
dc.subject.meshGeum - Chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrocirculation - Drug Effectsen_US
dc.subject.meshMyocardial Infarction - Drug Therapy - Pathology - Physiopathologyen_US
dc.subject.meshMyocardium - Pathologyen_US
dc.subject.meshMyocytes, Cardiac - Drug Effects - Pathologyen_US
dc.subject.meshNeovascularization, Physiologic - Drug Effectsen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleRepair of infarcted myocardium by an extract of Geum japonicum with dual effects on angiogenesis and myogenesisen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1373/clinchem.2006.068247en_US
dc.identifier.pmid16873297-
dc.identifier.scopuseid_2-s2.0-33746610944en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746610944&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume52en_US
dc.identifier.issue8en_US
dc.identifier.spage1460en_US
dc.identifier.epage1468en_US
dc.identifier.isiWOS:000239480300002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, M=36066390600en_US
dc.identifier.scopusauthoridYu, CM=7404976646en_US
dc.identifier.scopusauthoridCheng, L=7403337743en_US
dc.identifier.scopusauthoridWang, M=7406690398en_US
dc.identifier.scopusauthoridGu, X=13003097500en_US
dc.identifier.scopusauthoridLee, KH=7501505976en_US
dc.identifier.scopusauthoridWang, T=14055316100en_US
dc.identifier.scopusauthoridSung, YT=16553577500en_US
dc.identifier.scopusauthoridSanderson, JE=7202371250en_US

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