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Article: Advanced glycation endproducts in nondiabetic patients with obstructive sleep apnea

TitleAdvanced glycation endproducts in nondiabetic patients with obstructive sleep apnea
Authors
KeywordsAdvanced Glycation End Products
Obstructive Sleep Apnoea
Oxidative Stress
Issue Date2006
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
Citation
Sleep, 2006, v. 29 n. 3, p. 329-333 How to Cite?
AbstractSubject Objective: The formation and accumulation of advanced glycation endproducts (AGEs) has been implicated in the progression of age-related diseases such as diabetes mellitus and atherosclerosis. We hypothesize that AGE concentrations may be increased in subjects with obstructive sleep apnea (OSA), a condition associated with increased oxidative stress. Methods: One hundred nineteen nondiabetic patients with OSA and 234 age-matched healthy controls and 134 patients with type 2 diabetes were recruited for participation in the study. Serum AGEs were assayed by competitive enzyme-linked immunosorbent assay using a polydonal rabbit antisera raised against AGE-RNase. Results: Serum AGEs were increased in OSA subjects, as compared with controls, but were less increased than the AGEs of patients with type 2 diabetes (control: 3.22 ± 0.54 unit per mL; OSA: 3.68 ± 0.39; diabetes mellitus: 4.11 ± 0.99; analysis of variance p < .01). In the subjects with OSA, serum AGEs correlated with the duration of nocturnal desaturation (r = 0.21, p = .025) and plasma total 8-isoprostane concentration, a biochemical marker of oxidative stress (r = 0.22, p = .015), but not with fasting glucose level. On general linear model univariate analysis, the association between serum AGEs and 8-isoprostane was independent of age, sex, body mass index, smoking status, and glucose. Conclusion: Serum levels of AGEs were increased in nondiabetic subjects with OSA and were associated with the severity of OSA. Whether increased AGE formation contributes significantly to the high cardiovascular risk associated with OSA remains to be determined.
Persistent Identifierhttp://hdl.handle.net/10722/162993
ISSN
2015 Impact Factor: 4.793
2015 SCImago Journal Rankings: 2.606
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_US
dc.contributor.authorChow, WSCen_US
dc.contributor.authorLam, JCMen_US
dc.contributor.authorLam, Ben_US
dc.contributor.authorBucala, Ren_US
dc.contributor.authorBetteridge, Jen_US
dc.contributor.authorIp, MSMen_US
dc.date.accessioned2012-09-05T05:26:21Z-
dc.date.available2012-09-05T05:26:21Z-
dc.date.issued2006en_US
dc.identifier.citationSleep, 2006, v. 29 n. 3, p. 329-333en_US
dc.identifier.issn0161-8105en_US
dc.identifier.urihttp://hdl.handle.net/10722/162993-
dc.description.abstractSubject Objective: The formation and accumulation of advanced glycation endproducts (AGEs) has been implicated in the progression of age-related diseases such as diabetes mellitus and atherosclerosis. We hypothesize that AGE concentrations may be increased in subjects with obstructive sleep apnea (OSA), a condition associated with increased oxidative stress. Methods: One hundred nineteen nondiabetic patients with OSA and 234 age-matched healthy controls and 134 patients with type 2 diabetes were recruited for participation in the study. Serum AGEs were assayed by competitive enzyme-linked immunosorbent assay using a polydonal rabbit antisera raised against AGE-RNase. Results: Serum AGEs were increased in OSA subjects, as compared with controls, but were less increased than the AGEs of patients with type 2 diabetes (control: 3.22 ± 0.54 unit per mL; OSA: 3.68 ± 0.39; diabetes mellitus: 4.11 ± 0.99; analysis of variance p < .01). In the subjects with OSA, serum AGEs correlated with the duration of nocturnal desaturation (r = 0.21, p = .025) and plasma total 8-isoprostane concentration, a biochemical marker of oxidative stress (r = 0.22, p = .015), but not with fasting glucose level. On general linear model univariate analysis, the association between serum AGEs and 8-isoprostane was independent of age, sex, body mass index, smoking status, and glucose. Conclusion: Serum levels of AGEs were increased in nondiabetic subjects with OSA and were associated with the severity of OSA. Whether increased AGE formation contributes significantly to the high cardiovascular risk associated with OSA remains to be determined.en_US
dc.languageengen_US
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.orgen_US
dc.relation.ispartofSleepen_US
dc.subjectAdvanced Glycation End Productsen_US
dc.subjectObstructive Sleep Apnoeaen_US
dc.subjectOxidative Stressen_US
dc.titleAdvanced glycation endproducts in nondiabetic patients with obstructive sleep apneaen_US
dc.typeArticleen_US
dc.identifier.emailTan, KCB:kcbtan@hku.hken_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.authorityTan, KCB=rp00402en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16553018-
dc.identifier.scopuseid_2-s2.0-33745790744en_US
dc.identifier.hkuros115903-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745790744&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.spage329en_US
dc.identifier.epage333en_US
dc.identifier.isiWOS:000240123600008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTan, KCB=8082703100en_US
dc.identifier.scopusauthoridChow, WS=7402281153en_US
dc.identifier.scopusauthoridLam, JCM=25923453500en_US
dc.identifier.scopusauthoridLam, B=9246012800en_US
dc.identifier.scopusauthoridBucala, R=7102379822en_US
dc.identifier.scopusauthoridBetteridge, J=7004113903en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US

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