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Article: Safety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
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TitleSafety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
 
AuthorsTse, HF1
Thambar, S2
Kwong, YL1
Rowlings, P2
Bellamy, G2
Mccrohon, J2
Bastian, B2
Chan, JKF3
Lo, G3
Ho, CL3
Lau, CP1
 
Issue Date2006
 
PublisherElsevier Inc. The Journal's web site is located at http://www.ajconline.org/
 
CitationAmerican Journal Of Cardiology, 2006, v. 98 n. 1, p. 60-62 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2006.01.056
 
AbstractThe long-term safety and efficacy of autologous bone marrow cell implantation into the myocardium remains undefined. We studied the long-term clinical outcome of 12 patients with severe coronary artery disease who underwent electromechanical mapping-guided catheter-based autologous bone marrow cell implantation. Magnetic resonance imaging at 3 and 6 months showed no evidence of intramyocardial tumor formation, myocardial damage, or worsening of left ventricular ejection fraction. No sustained arrhythmia was detected on 24-hour Holter monitoring. After 44 ± 10 months of follow-up, 1 patient had died of stroke at 8 months and another patient had died of myocardial infarction at 20 months. Computed tomography at 36 months or postmortem examination showed no tumor formation or intramyocardial calcification at the treated sites, and no sustained ventricular arrhythmia or sudden death was observed. Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low. © 2006 Elsevier Inc. All rights reserved.
 
ISSN0002-9149
2012 Impact Factor: 3.209
2012 SCImago Journal Rankings: 1.912
 
DOIhttp://dx.doi.org/10.1016/j.amjcard.2006.01.056
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTse, HF
 
dc.contributor.authorThambar, S
 
dc.contributor.authorKwong, YL
 
dc.contributor.authorRowlings, P
 
dc.contributor.authorBellamy, G
 
dc.contributor.authorMccrohon, J
 
dc.contributor.authorBastian, B
 
dc.contributor.authorChan, JKF
 
dc.contributor.authorLo, G
 
dc.contributor.authorHo, CL
 
dc.contributor.authorLau, CP
 
dc.date.accessioned2012-09-05T05:26:16Z
 
dc.date.available2012-09-05T05:26:16Z
 
dc.date.issued2006
 
dc.description.abstractThe long-term safety and efficacy of autologous bone marrow cell implantation into the myocardium remains undefined. We studied the long-term clinical outcome of 12 patients with severe coronary artery disease who underwent electromechanical mapping-guided catheter-based autologous bone marrow cell implantation. Magnetic resonance imaging at 3 and 6 months showed no evidence of intramyocardial tumor formation, myocardial damage, or worsening of left ventricular ejection fraction. No sustained arrhythmia was detected on 24-hour Holter monitoring. After 44 ± 10 months of follow-up, 1 patient had died of stroke at 8 months and another patient had died of myocardial infarction at 20 months. Computed tomography at 36 months or postmortem examination showed no tumor formation or intramyocardial calcification at the treated sites, and no sustained ventricular arrhythmia or sudden death was observed. Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low. © 2006 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Cardiology, 2006, v. 98 n. 1, p. 60-62 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2006.01.056
 
dc.identifier.citeulike908905
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.amjcard.2006.01.056
 
dc.identifier.epage62
 
dc.identifier.hkuros117102
 
dc.identifier.issn0002-9149
2012 Impact Factor: 3.209
2012 SCImago Journal Rankings: 1.912
 
dc.identifier.issue1
 
dc.identifier.pmid16784921
 
dc.identifier.scopuseid_2-s2.0-33745139807
 
dc.identifier.spage60
 
dc.identifier.urihttp://hdl.handle.net/10722/162987
 
dc.identifier.volume98
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.ajconline.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAngina Pectoris - Complications - Therapy
 
dc.subject.meshBone Marrow Transplantation - Adverse Effects
 
dc.subject.meshCoronary Artery Disease - Complications - Therapy
 
dc.subject.meshElectrocardiography, Ambulatory
 
dc.subject.meshEndocardium
 
dc.subject.meshFemale
 
dc.subject.meshHeart Catheterization - Methods
 
dc.subject.meshHumans
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshProspective Studies
 
dc.subject.meshSafety
 
dc.subject.meshTransplantation, Autologous
 
dc.subject.meshTreatment Outcome
 
dc.titleSafety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. John Hunter Hospital
  3. Hong Kong Sanatorium and Hospital