Article: Safety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis

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TitleSafety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
AuthorsTse, HF1
Thambar, S2
Kwong, YL1
Rowlings, P2
Bellamy, G2
Mccrohon, J2
Bastian, B2
Chan, JKF3
Lo, G3
Ho, CL3
Lau, CP1
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.ajconline.org/
CitationAmerican Journal Of Cardiology, 2006, v. 98 n. 1, p. 60-62 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2006.01.056
AbstractThe long-term safety and efficacy of autologous bone marrow cell implantation into the myocardium remains undefined. We studied the long-term clinical outcome of 12 patients with severe coronary artery disease who underwent electromechanical mapping-guided catheter-based autologous bone marrow cell implantation. Magnetic resonance imaging at 3 and 6 months showed no evidence of intramyocardial tumor formation, myocardial damage, or worsening of left ventricular ejection fraction. No sustained arrhythmia was detected on 24-hour Holter monitoring. After 44 ± 10 months of follow-up, 1 patient had died of stroke at 8 months and another patient had died of myocardial infarction at 20 months. Computed tomography at 36 months or postmortem examination showed no tumor formation or intramyocardial calcification at the treated sites, and no sustained ventricular arrhythmia or sudden death was observed. Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low. © 2006 Elsevier Inc. All rights reserved.
ISSN0002-9149
2011 Impact Factor: 3.368
2011 SCImago Journal Rankings: 0.371
DOIhttp://dx.doi.org/10.1016/j.amjcard.2006.01.056
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTse, HF
dc.contributor.authorThambar, S
dc.contributor.authorKwong, YL
dc.contributor.authorRowlings, P
dc.contributor.authorBellamy, G
dc.contributor.authorMccrohon, J
dc.contributor.authorBastian, B
dc.contributor.authorChan, JKF
dc.contributor.authorLo, G
dc.contributor.authorHo, CL
dc.contributor.authorLau, CP
dc.date.accessioned2012-09-05T05:26:16Z
dc.date.available2012-09-05T05:26:16Z
dc.date.issued2006
dc.description.abstractThe long-term safety and efficacy of autologous bone marrow cell implantation into the myocardium remains undefined. We studied the long-term clinical outcome of 12 patients with severe coronary artery disease who underwent electromechanical mapping-guided catheter-based autologous bone marrow cell implantation. Magnetic resonance imaging at 3 and 6 months showed no evidence of intramyocardial tumor formation, myocardial damage, or worsening of left ventricular ejection fraction. No sustained arrhythmia was detected on 24-hour Holter monitoring. After 44 ± 10 months of follow-up, 1 patient had died of stroke at 8 months and another patient had died of myocardial infarction at 20 months. Computed tomography at 36 months or postmortem examination showed no tumor formation or intramyocardial calcification at the treated sites, and no sustained ventricular arrhythmia or sudden death was observed. Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low. © 2006 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAmerican Journal Of Cardiology, 2006, v. 98 n. 1, p. 60-62 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2006.01.056
dc.identifier.citeulike908905
dc.identifier.doihttp://dx.doi.org/10.1016/j.amjcard.2006.01.056
dc.identifier.epage62
dc.identifier.hkuros117102
dc.identifier.issn0002-9149
2011 Impact Factor: 3.368
2011 SCImago Journal Rankings: 0.371
dc.identifier.issue1
dc.identifier.pmid16784921
dc.identifier.scopuseid_2-s2.0-33745139807
dc.identifier.spage60
dc.identifier.urihttp://hdl.handle.net/10722/162987
dc.identifier.volume98
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.ajconline.org/
dc.publisher.placeUnited States
dc.relation.ispartofAmerican Journal of Cardiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAngina Pectoris - Complications - Therapy
dc.subject.meshBone Marrow Transplantation - Adverse Effects
dc.subject.meshCoronary Artery Disease - Complications - Therapy
dc.subject.meshElectrocardiography, Ambulatory
dc.subject.meshEndocardium
dc.subject.meshFemale
dc.subject.meshHeart Catheterization - Methods
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProspective Studies
dc.subject.meshSafety
dc.subject.meshTransplantation, Autologous
dc.subject.meshTreatment Outcome
dc.titleSafety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. John Hunter Hospital
  3. Hong Kong Sanatorium and Hospital