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Article: Safety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis

TitleSafety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
Authors
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2006, v. 98 n. 1, p. 60-62 How to Cite?
Abstract
The long-term safety and efficacy of autologous bone marrow cell implantation into the myocardium remains undefined. We studied the long-term clinical outcome of 12 patients with severe coronary artery disease who underwent electromechanical mapping-guided catheter-based autologous bone marrow cell implantation. Magnetic resonance imaging at 3 and 6 months showed no evidence of intramyocardial tumor formation, myocardial damage, or worsening of left ventricular ejection fraction. No sustained arrhythmia was detected on 24-hour Holter monitoring. After 44 ± 10 months of follow-up, 1 patient had died of stroke at 8 months and another patient had died of myocardial infarction at 20 months. Computed tomography at 36 months or postmortem examination showed no tumor formation or intramyocardial calcification at the treated sites, and no sustained ventricular arrhythmia or sudden death was observed. Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162987
ISSN
2013 Impact Factor: 3.425
2013 SCImago Journal Rankings: 2.315
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. John Hunter Hospital
  3. Hong Kong Sanatorium and Hospital
DC FieldValueLanguage
dc.contributor.authorTse, HFen_US
dc.contributor.authorThambar, Sen_US
dc.contributor.authorKwong, YLen_US
dc.contributor.authorRowlings, Pen_US
dc.contributor.authorBellamy, Gen_US
dc.contributor.authorMccrohon, Jen_US
dc.contributor.authorBastian, Ben_US
dc.contributor.authorChan, JKFen_US
dc.contributor.authorLo, Gen_US
dc.contributor.authorHo, CLen_US
dc.contributor.authorLau, CPen_US
dc.date.accessioned2012-09-05T05:26:16Z-
dc.date.available2012-09-05T05:26:16Z-
dc.date.issued2006en_US
dc.identifier.citationAmerican Journal Of Cardiology, 2006, v. 98 n. 1, p. 60-62en_US
dc.identifier.issn0002-9149en_US
dc.identifier.urihttp://hdl.handle.net/10722/162987-
dc.description.abstractThe long-term safety and efficacy of autologous bone marrow cell implantation into the myocardium remains undefined. We studied the long-term clinical outcome of 12 patients with severe coronary artery disease who underwent electromechanical mapping-guided catheter-based autologous bone marrow cell implantation. Magnetic resonance imaging at 3 and 6 months showed no evidence of intramyocardial tumor formation, myocardial damage, or worsening of left ventricular ejection fraction. No sustained arrhythmia was detected on 24-hour Holter monitoring. After 44 ± 10 months of follow-up, 1 patient had died of stroke at 8 months and another patient had died of myocardial infarction at 20 months. Computed tomography at 36 months or postmortem examination showed no tumor formation or intramyocardial calcification at the treated sites, and no sustained ventricular arrhythmia or sudden death was observed. Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low. © 2006 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.ajconline.org/en_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAngina Pectoris - Complications - Therapyen_US
dc.subject.meshBone Marrow Transplantation - Adverse Effectsen_US
dc.subject.meshCoronary Artery Disease - Complications - Therapyen_US
dc.subject.meshElectrocardiography, Ambulatoryen_US
dc.subject.meshEndocardiumen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Catheterization - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSafetyen_US
dc.subject.meshTransplantation, Autologousen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleSafety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesisen_US
dc.typeArticleen_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.amjcard.2006.01.056en_US
dc.identifier.pmid16784921en_US
dc.identifier.scopuseid_2-s2.0-33745139807en_US
dc.identifier.hkuros117102-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745139807&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume98en_US
dc.identifier.issue1en_US
dc.identifier.spage60en_US
dc.identifier.epage62en_US
dc.identifier.isiWOS:000238896900013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US
dc.identifier.scopusauthoridThambar, S=6508108817en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridRowlings, P=7003519846en_US
dc.identifier.scopusauthoridBellamy, G=7006844978en_US
dc.identifier.scopusauthoridMcCrohon, J=6602810028en_US
dc.identifier.scopusauthoridBastian, B=7005685003en_US
dc.identifier.scopusauthoridChan, JKF=7403287057en_US
dc.identifier.scopusauthoridLo, G=7101880732en_US
dc.identifier.scopusauthoridHo, CL=7404653628en_US
dc.identifier.scopusauthoridLau, CP=7401968501en_US
dc.identifier.citeulike908905-

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