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Article: Association of MEGSIN 2093C-2180T haplotype at the 3′ untranslated region with disease severity and progression of IgA nephropathy

TitleAssociation of MEGSIN 2093C-2180T haplotype at the 3′ untranslated region with disease severity and progression of IgA nephropathy
Authors
KeywordsChinese
Genetic variations
Genotype-phenotype relationship
IgAN
MEGSIN
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
Nephrology Dialysis Transplantation, 2006, v. 21 n. 6, p. 1570-1574 How to Cite?
AbstractBackground. MEGSIN is a gene predominantly expressed in the renal mesangium, and is upregulated in IgA nephropathy (IgAN). Our previous study has shown that the 2093C and 2180T alleles at the 3′ untranslated region (3′UTR) of the gene are associated with susceptibility to IgAN, but the relationships of these genetic variants with the clinical manifestations and renal histological lesions of IgAN have not been examined previously. Methods. 302 IgAN patients followed up for 52.8±22.5 months were investigated. Haplotypes at the 3′UTR were constructed using the 2093C/T and 2180C/T alleles. The genotype-phenotype relationship was studied by correlations of haplotypes and the clinical data and renal histopathological changes. Results. The 2093C-2180T haplotype was present more often in patients with disease that progressed more rapidly (χ 2 (C-T/others) = 8.429, P = 0.004), and was also correlated with hypertension (χ 2 (C-T/others) = 6.459, P = 0.012), severe proteinuria (≥2 g/d) (χ 2 (C-T/others) = 6.332, P = 0.013), and Lee's class IV and V histological changes (χ 2 (C-T/others) = 9.640, P = 0.008). Conclusion. In this Chinese population, the 2093C-2180T haplotype at the 3′UTR of MEGSIN gene is associated with more severe forms of IgAN, and more rapid disease progression. This provides further evidence for the involvement of genetic variations of MEGSIN in the pathogenesis of IgAN. © 2006 Oxford University Press.
Persistent Identifierhttp://hdl.handle.net/10722/162982
ISSN
2015 Impact Factor: 4.085
2015 SCImago Journal Rankings: 1.780
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, Yen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorDu, Yen_HK
dc.contributor.authorYang, Nen_HK
dc.contributor.authorLi, Cen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorHuang, Wen_HK
dc.contributor.authorChen, Sen_HK
dc.contributor.authorMaxwell, PHen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorWang, Yen_HK
dc.date.accessioned2012-09-05T05:26:12Z-
dc.date.available2012-09-05T05:26:12Z-
dc.date.issued2006en_HK
dc.identifier.citationNephrology Dialysis Transplantation, 2006, v. 21 n. 6, p. 1570-1574en_HK
dc.identifier.issn0931-0509en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162982-
dc.description.abstractBackground. MEGSIN is a gene predominantly expressed in the renal mesangium, and is upregulated in IgA nephropathy (IgAN). Our previous study has shown that the 2093C and 2180T alleles at the 3′ untranslated region (3′UTR) of the gene are associated with susceptibility to IgAN, but the relationships of these genetic variants with the clinical manifestations and renal histological lesions of IgAN have not been examined previously. Methods. 302 IgAN patients followed up for 52.8±22.5 months were investigated. Haplotypes at the 3′UTR were constructed using the 2093C/T and 2180C/T alleles. The genotype-phenotype relationship was studied by correlations of haplotypes and the clinical data and renal histopathological changes. Results. The 2093C-2180T haplotype was present more often in patients with disease that progressed more rapidly (χ 2 (C-T/others) = 8.429, P = 0.004), and was also correlated with hypertension (χ 2 (C-T/others) = 6.459, P = 0.012), severe proteinuria (≥2 g/d) (χ 2 (C-T/others) = 6.332, P = 0.013), and Lee's class IV and V histological changes (χ 2 (C-T/others) = 9.640, P = 0.008). Conclusion. In this Chinese population, the 2093C-2180T haplotype at the 3′UTR of MEGSIN gene is associated with more severe forms of IgAN, and more rapid disease progression. This provides further evidence for the involvement of genetic variations of MEGSIN in the pathogenesis of IgAN. © 2006 Oxford University Press.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/en_HK
dc.relation.ispartofNephrology Dialysis Transplantationen_HK
dc.subjectChineseen_HK
dc.subjectGenetic variationsen_HK
dc.subjectGenotype-phenotype relationshipen_HK
dc.subjectIgANen_HK
dc.subjectMEGSINen_HK
dc.subject.mesh3' Untranslated Regions - Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGlomerulonephritis, Iga - Diagnosis - Geneticsen_US
dc.subject.meshHaplotypes - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertensionen_US
dc.subject.meshMaleen_US
dc.subject.meshProteinuriaen_US
dc.subject.meshSerpins - Geneticsen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.titleAssociation of MEGSIN 2093C-2180T haplotype at the 3′ untranslated region with disease severity and progression of IgA nephropathyen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/ndt/gfk096en_HK
dc.identifier.pmid16431886en_HK
dc.identifier.scopuseid_2-s2.0-33744790329en_HK
dc.identifier.hkuros121475-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33744790329&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1570en_HK
dc.identifier.epage1574en_HK
dc.identifier.isiWOS:000238538100017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXia, Y=55248957900en_HK
dc.identifier.scopusauthoridLi, Y=49763458100en_HK
dc.identifier.scopusauthoridDu, Y=49762851000en_HK
dc.identifier.scopusauthoridYang, N=7202173206en_HK
dc.identifier.scopusauthoridLi, C=26663041900en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLam, MF=35300050600en_HK
dc.identifier.scopusauthoridHuang, W=10041590500en_HK
dc.identifier.scopusauthoridChen, S=13907637100en_HK
dc.identifier.scopusauthoridMaxwell, PH=35399996300en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridWang, Y=13310049900en_HK
dc.identifier.citeulike678676-

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