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Article: Association of intestinal granulomas with smoking, phenotype, and serology in Chinese patients with Crohn's disease

TitleAssociation of intestinal granulomas with smoking, phenotype, and serology in Chinese patients with Crohn's disease
Authors
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 2006, v. 101 n. 5, p. 1024-1029 How to Cite?
AbstractINTRODUCTION: Crohn's disease (CD) is a heterogenous disease characterized by variable manifestations and outcomes, and increasing in incidence in China. Phenotypic classification has been proposed to assist in subtyping of disease. Non-caseating intestinal granulomas are a hallmark of CD, but whether intestinal granulomas help predict Chinese CD phenotypes or determine severity, is not known. AIMS: To determine the association between intestinal granulomas with CD phenotype, severity, risk factors, and serological markers. METHODS: This was a single-centre study of consecutive definite Chinese CD cases. Granulomas were diagnosed by an experienced GI pathologist. Correlation with the Vienna Classification and other parameters was performed. RESULTS: Eighty Chinese CD patients were recruited, 40 (50%) of whom had intestinal granulomas. Intestinal granulomas were independently associated with the stricturing behavior (OR: 4.71; 95% CI: 1.41-15.72), colonic location of disease (OR: 26.96; 95% CI: 2.68-271.14), but not with age of CD diagnosis. Current or previous smoking protected against the development of granulomas (OR: 0.16; 95% CI: 0.04-0.59). Granulomas were not associated with peri-anal involvement, extra-intestinal manifestations, anti-neutrophil cytoplasmic antibody or anti-Saccharomyces cerevisiae antibody serology, or severity of CD gauged by the requirement of major intestinal surgery or immunomodulating therapy. CONCLUSIONS: Intestinal granulomas in the setting of CD may be helpful in determining phenotypic subtypes of CD, but is unhelpful in predicting disease severity. Smoking impairs the formation of granulomas in CD. © 2006 by Am. Coll. of Gastroenterology.
Persistent Identifierhttp://hdl.handle.net/10722/162976
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeong, RWLen_US
dc.contributor.authorLawrance, ICen_US
dc.contributor.authorChow, DKLen_US
dc.contributor.authorTo, KFen_US
dc.contributor.authorLau, JYen_US
dc.contributor.authorWu, Jen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:26:07Z-
dc.date.available2012-09-05T05:26:07Z-
dc.date.issued2006en_US
dc.identifier.citationAmerican Journal Of Gastroenterology, 2006, v. 101 n. 5, p. 1024-1029en_US
dc.identifier.issn0002-9270en_US
dc.identifier.urihttp://hdl.handle.net/10722/162976-
dc.description.abstractINTRODUCTION: Crohn's disease (CD) is a heterogenous disease characterized by variable manifestations and outcomes, and increasing in incidence in China. Phenotypic classification has been proposed to assist in subtyping of disease. Non-caseating intestinal granulomas are a hallmark of CD, but whether intestinal granulomas help predict Chinese CD phenotypes or determine severity, is not known. AIMS: To determine the association between intestinal granulomas with CD phenotype, severity, risk factors, and serological markers. METHODS: This was a single-centre study of consecutive definite Chinese CD cases. Granulomas were diagnosed by an experienced GI pathologist. Correlation with the Vienna Classification and other parameters was performed. RESULTS: Eighty Chinese CD patients were recruited, 40 (50%) of whom had intestinal granulomas. Intestinal granulomas were independently associated with the stricturing behavior (OR: 4.71; 95% CI: 1.41-15.72), colonic location of disease (OR: 26.96; 95% CI: 2.68-271.14), but not with age of CD diagnosis. Current or previous smoking protected against the development of granulomas (OR: 0.16; 95% CI: 0.04-0.59). Granulomas were not associated with peri-anal involvement, extra-intestinal manifestations, anti-neutrophil cytoplasmic antibody or anti-Saccharomyces cerevisiae antibody serology, or severity of CD gauged by the requirement of major intestinal surgery or immunomodulating therapy. CONCLUSIONS: Intestinal granulomas in the setting of CD may be helpful in determining phenotypic subtypes of CD, but is unhelpful in predicting disease severity. Smoking impairs the formation of granulomas in CD. © 2006 by Am. Coll. of Gastroenterology.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_US
dc.relation.ispartofAmerican Journal of Gastroenterologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Antineutrophil Cytoplasmic - Analysisen_US
dc.subject.meshAntibodies, Fungal - Analysisen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshChinaen_US
dc.subject.meshCrohn Disease - Complications - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGranuloma - Complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestinal Diseases - Complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSaccharomyces Cerevisiae - Immunologyen_US
dc.subject.meshSmokingen_US
dc.titleAssociation of intestinal granulomas with smoking, phenotype, and serology in Chinese patients with Crohn's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1572-0241.2006.00503.xen_US
dc.identifier.pmid16573779-
dc.identifier.scopuseid_2-s2.0-33646544038en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646544038&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume101en_US
dc.identifier.issue5en_US
dc.identifier.spage1024en_US
dc.identifier.epage1029en_US
dc.identifier.isiWOS:000237463300018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeong, RWL=24343912800en_US
dc.identifier.scopusauthoridLawrance, IC=6602338764en_US
dc.identifier.scopusauthoridChow, DKL=12760026500en_US
dc.identifier.scopusauthoridTo, KF=7101911940en_US
dc.identifier.scopusauthoridLau, JY=13907867100en_US
dc.identifier.scopusauthoridWu, J=7409253910en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.citeulike641193-

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