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Article: Effect of a non-adjustable oral appliance on upper airway morphology in obstructive sleep apnoea

TitleEffect of a non-adjustable oral appliance on upper airway morphology in obstructive sleep apnoea
Authors
Issue Date2006
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 2006, v. 100 n. 5, p. 897-902 How to Cite?
AbstractBackground: To evaluate the effect of oral appliance (OA) on upper airway morphology and its relationship with treatment response in subjects with obstructive sleep apnoea (OSA). Methods: Symptomatic OSA subjects were recruited. Non-adjustable OA was custom made. Variables examined at baseline and while wearing the device at 2 months included polysomnographic data, computed tomographic measurements of upper airway cross sectional area at level of velopharynx (VA) and hypopharynx (HA), upper airway volume, and cephalometric parameters. Treatment outcome was based on post-treatment apnoea-hypopnoea index (AHI). Results: Forty patients were recruited and 23 (7 women) completed the study. They were middle-aged (49, 40-58 years) (median, interquartile range) and overweight (BMI 26, 23.3-29.5 kg/m 2), with moderate OSA (AHI 26.4, 14.1-36). The overall post treatment AHI was 8.4 (2.4-12.5), with 14 (61%) patients showing good response (AHI<10), and the other 9 patients showing moderate response (>50% reduction in AHI but still {greater than or slanted equal to}10). OA decreased the cross-sectional area of the HA (P=0.046), showed a trend of decreasing the ratio of cross-sectional area of the HA to cross-sectional area of the VA (P=0.053) and significantly increased the overall upper airway volume (P=0.006, n=11). No significant relationship between upper airway parameters and treatment outcome was identified. Conclusions: OA altered upper airway morphometry towards a profile consistent with decreased propensity to collapse, which may thus have contributed to improvement of OSA. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162964
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.396
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSam, Ken_US
dc.contributor.authorLam, Ben_US
dc.contributor.authorOoi, CGen_US
dc.contributor.authorCooke, Men_US
dc.contributor.authorIp, MSen_US
dc.date.accessioned2012-09-05T05:25:57Z-
dc.date.available2012-09-05T05:25:57Z-
dc.date.issued2006en_US
dc.identifier.citationRespiratory Medicine, 2006, v. 100 n. 5, p. 897-902en_US
dc.identifier.issn0954-6111en_US
dc.identifier.urihttp://hdl.handle.net/10722/162964-
dc.description.abstractBackground: To evaluate the effect of oral appliance (OA) on upper airway morphology and its relationship with treatment response in subjects with obstructive sleep apnoea (OSA). Methods: Symptomatic OSA subjects were recruited. Non-adjustable OA was custom made. Variables examined at baseline and while wearing the device at 2 months included polysomnographic data, computed tomographic measurements of upper airway cross sectional area at level of velopharynx (VA) and hypopharynx (HA), upper airway volume, and cephalometric parameters. Treatment outcome was based on post-treatment apnoea-hypopnoea index (AHI). Results: Forty patients were recruited and 23 (7 women) completed the study. They were middle-aged (49, 40-58 years) (median, interquartile range) and overweight (BMI 26, 23.3-29.5 kg/m 2), with moderate OSA (AHI 26.4, 14.1-36). The overall post treatment AHI was 8.4 (2.4-12.5), with 14 (61%) patients showing good response (AHI<10), and the other 9 patients showing moderate response (>50% reduction in AHI but still {greater than or slanted equal to}10). OA decreased the cross-sectional area of the HA (P=0.046), showed a trend of decreasing the ratio of cross-sectional area of the HA to cross-sectional area of the VA (P=0.053) and significantly increased the overall upper airway volume (P=0.006, n=11). No significant relationship between upper airway parameters and treatment outcome was identified. Conclusions: OA altered upper airway morphometry towards a profile consistent with decreased propensity to collapse, which may thus have contributed to improvement of OSA. © 2005 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshCephalometryen_US
dc.subject.meshExhalation - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMandibular Advancement - Instrumentationen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPharynx - Pathology - Radiographyen_US
dc.subject.meshPolysomnographyen_US
dc.subject.meshSleep Apnea, Obstructive - Pathology - Physiopathology - Radiographyen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleEffect of a non-adjustable oral appliance on upper airway morphology in obstructive sleep apnoeaen_US
dc.typeArticleen_US
dc.identifier.emailIp, MS:msmip@hku.hken_US
dc.identifier.authorityIp, MS=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.rmed.2005.08.019en_US
dc.identifier.pmid16219453en_US
dc.identifier.scopuseid_2-s2.0-33645873260en_US
dc.identifier.hkuros119020-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645873260&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume100en_US
dc.identifier.issue5en_US
dc.identifier.spage897en_US
dc.identifier.epage902en_US
dc.identifier.isiWOS:000237093500018-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSam, K=6603582227en_US
dc.identifier.scopusauthoridLam, B=9246012800en_US
dc.identifier.scopusauthoridOoi, CG=7007084909en_US
dc.identifier.scopusauthoridCooke, M=7202147454en_US
dc.identifier.scopusauthoridIp, MS=7102423259en_US

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