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Article: Polymorphisms in manganese superoxide dismutase and catalase genes: Functional study in Hong Kong Chinese asthma patients

TitlePolymorphisms in manganese superoxide dismutase and catalase genes: Functional study in Hong Kong Chinese asthma patients
Authors
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEA
Citation
Clinical And Experimental Allergy, 2006, v. 36 n. 4, p. 440-447 How to Cite?
AbstractBackground: Reactive oxygen species may contribute to the pathogenesis of asthma. Functional genetic polymorphisms of antioxidant enzymes, superoxide dismutase (SOD) and catalase are good candidates for asthma susceptibility. Objective: To investigate the association of the manganese-containing form of SOD (MnSOD) gene at amino acid position 16 (Val16Ala) and catalase gene in the promoter at A-21T and C-262T polymorphisms and asthma in a Hong Kong Chinese population. Methods: The association study was conducted in a case-control design in asthma patients (n=251) and healthy controls (n=316) by genotyping. The functional significance was assessed by determining erythrocyte SOD and catalase activity. Results: The Val allele of MnSOD at Val16Ala and the A allele of catalase gene at A-21T were not different between patients and controls, while the C allele of catalase gene at C-262T was found to be significantly different between patients and controls (P=0.033). The less frequent variant of catalase gene (-262T) was found to be protective from the development of asthma in a Hong Kong Chinese non-smoking population (adjusted odds ratio=0.35, 0.15-0.85; P=0.017). Asthma patients had elevated erythrocyte SOD and catalase activities in comparison with healthy controls (P<0.01). However, their activities were not associated with different genotypes within healthy controls or asthma patients. Conclusion: This is the first report showing that SOD and catalase functional activities are not associated with their respective genetic polymorphisms but related to the presence of asthma in a Hong Kong Chinese population. © 2006 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/162955
ISSN
2015 Impact Factor: 5.587
2015 SCImago Journal Rankings: 2.184
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_US
dc.contributor.authorLeung, HCMen_US
dc.contributor.authorHo, SPen_US
dc.contributor.authorKo, FWSen_US
dc.contributor.authorCheung, AHKen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorChanYeung, MMWen_US
dc.date.accessioned2012-09-05T05:25:51Z-
dc.date.available2012-09-05T05:25:51Z-
dc.date.issued2006en_US
dc.identifier.citationClinical And Experimental Allergy, 2006, v. 36 n. 4, p. 440-447en_US
dc.identifier.issn0954-7894en_US
dc.identifier.urihttp://hdl.handle.net/10722/162955-
dc.description.abstractBackground: Reactive oxygen species may contribute to the pathogenesis of asthma. Functional genetic polymorphisms of antioxidant enzymes, superoxide dismutase (SOD) and catalase are good candidates for asthma susceptibility. Objective: To investigate the association of the manganese-containing form of SOD (MnSOD) gene at amino acid position 16 (Val16Ala) and catalase gene in the promoter at A-21T and C-262T polymorphisms and asthma in a Hong Kong Chinese population. Methods: The association study was conducted in a case-control design in asthma patients (n=251) and healthy controls (n=316) by genotyping. The functional significance was assessed by determining erythrocyte SOD and catalase activity. Results: The Val allele of MnSOD at Val16Ala and the A allele of catalase gene at A-21T were not different between patients and controls, while the C allele of catalase gene at C-262T was found to be significantly different between patients and controls (P=0.033). The less frequent variant of catalase gene (-262T) was found to be protective from the development of asthma in a Hong Kong Chinese non-smoking population (adjusted odds ratio=0.35, 0.15-0.85; P=0.017). Asthma patients had elevated erythrocyte SOD and catalase activities in comparison with healthy controls (P<0.01). However, their activities were not associated with different genotypes within healthy controls or asthma patients. Conclusion: This is the first report showing that SOD and catalase functional activities are not associated with their respective genetic polymorphisms but related to the presence of asthma in a Hong Kong Chinese population. © 2006 Blackwell Publishing Ltd.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEAen_US
dc.relation.ispartofClinical and Experimental Allergyen_US
dc.rightsClinical and Experimental Allergy. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAllelesen_US
dc.subject.meshAsthma - Enzymology - Epidemiology - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCatalase - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFree Radical Scavengersen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking - Epidemiology - Geneticsen_US
dc.subject.meshSuperoxide Dismutase - Geneticsen_US
dc.titlePolymorphisms in manganese superoxide dismutase and catalase genes: Functional study in Hong Kong Chinese asthma patientsen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2222.2006.02458.xen_US
dc.identifier.pmid16630148en_US
dc.identifier.scopuseid_2-s2.0-33645276294en_US
dc.identifier.hkuros119000-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645276294&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue4en_US
dc.identifier.spage440en_US
dc.identifier.epage447en_US
dc.identifier.isiWOS:000236241900005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridLeung, HCM=34968372500en_US
dc.identifier.scopusauthoridHo, SP=12794365900en_US
dc.identifier.scopusauthoridKo, FWS=7103224911en_US
dc.identifier.scopusauthoridCheung, AHK=12795914100en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridChanYeung, MMW=54790582200en_US
dc.identifier.citeulike564173-

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