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Article: Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese

TitlePeroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese
Authors
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2006, v. 23 n. 2, p. 289-294 How to Cite?
AbstractBackground: Peroxisome proliferator-activated receptor γ inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. Aim: To study the association between peroxisome proliferator-activated receptor γ gene polymorphism, Helicobacter pylori infection and gastric cancer in Chinese. Methods: One hundred and four consecutive patients with non-cardia gastric adenocarcinoma and 104 matched controls were examined. Peroxisome proliferator-activated receptor γ Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequency of peroxisome proliferator-activated receptor γ G (Ala12) allele was significantly higher among cancer patients (19.2%) than in control (8.7%; OR 2.5, 95% CI 1.1-5.8). While H. pylori infection was more prevalent in gastric cancer patients (OR 3.0; 95% CI 1.6-5.7), the combination of peroxisome proliferator-activated receptor γ G allele and H. pylori infection further increased the risk of gastric cancer (OR 12.8, 95% CI 3.2-50.5). The presence of the Ala12 did not increase the risk of gastric cancer in H. pylori-negative subjects. Conclusion: Our study suggests the potential association between peroxisome proliferator-activated receptor γ polymorphism and H. pylori infection in the development of non-cardia gastric cancer. © 2006 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/162948
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiao, SYen_US
dc.contributor.authorZeng, ZRen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorZhou, SZen_US
dc.contributor.authorChen, Ben_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorHu, PJen_US
dc.date.accessioned2012-09-05T05:25:45Z-
dc.date.available2012-09-05T05:25:45Z-
dc.date.issued2006en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2006, v. 23 n. 2, p. 289-294en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/162948-
dc.description.abstractBackground: Peroxisome proliferator-activated receptor γ inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. Aim: To study the association between peroxisome proliferator-activated receptor γ gene polymorphism, Helicobacter pylori infection and gastric cancer in Chinese. Methods: One hundred and four consecutive patients with non-cardia gastric adenocarcinoma and 104 matched controls were examined. Peroxisome proliferator-activated receptor γ Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequency of peroxisome proliferator-activated receptor γ G (Ala12) allele was significantly higher among cancer patients (19.2%) than in control (8.7%; OR 2.5, 95% CI 1.1-5.8). While H. pylori infection was more prevalent in gastric cancer patients (OR 3.0; 95% CI 1.6-5.7), the combination of peroxisome proliferator-activated receptor γ G allele and H. pylori infection further increased the risk of gastric cancer (OR 12.8, 95% CI 3.2-50.5). The presence of the Ala12 did not increase the risk of gastric cancer in H. pylori-negative subjects. Conclusion: Our study suggests the potential association between peroxisome proliferator-activated receptor γ polymorphism and H. pylori infection in the development of non-cardia gastric cancer. © 2006 Blackwell Publishing Ltd.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.subject.meshAdenocarcinoma - Genetics - Microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPpar Gamma - Geneticsen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStomach Neoplasms - Genetics - Microbiologyen_US
dc.titlePeroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2036.2006.02739.xen_US
dc.identifier.pmid16393309-
dc.identifier.scopuseid_2-s2.0-33644886282en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644886282&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue2en_US
dc.identifier.spage289en_US
dc.identifier.epage294en_US
dc.identifier.isiWOS:000234161400011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLiao, SY=12778706400en_US
dc.identifier.scopusauthoridZeng, ZR=7402647305en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridZhou, SZ=22939638900en_US
dc.identifier.scopusauthoridChen, B=25122481900en_US
dc.identifier.scopusauthoridSung, JJY=24473715000en_US
dc.identifier.scopusauthoridHu, PJ=7201989582en_US
dc.identifier.citeulike447634-

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