File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population

TitleA family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population
Authors
Issue Date2006
PublisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.com
Citation
Clinical Nephrology, 2006, v. 65 n. 3, p. 153-159 How to Cite?
AbstractAims: To investigate the association of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in Chinese population. Methods: 435 IgA nephropathy patients and their family members were recruited for a family-based association study. Genotypes of megsin A23167G were determined by direct sequencing. The results were analyzed by transmission disequilibrium test (TDT) and haplotype relative risk (HRR). Clinical data and histological scores of renal lesions were compared between patients with different genotypes. According to disease stability, IgA nephropathy patients were divided into progressive group and stable group. The distribution of genotype frequencies were compared between the 2 groups. Results: TDT revealed that megsin 23167G alleles were transmitted more frequently from heterozygous parents to patients than expected (classical TDT: χ 2 = 5.435, p = 0.020, extended TDT: χ 2 = 5.017, p = 0.025). HRR analyses showed significant differences between transmitted and nontransmitted allele frequencies (χ 2 = 7.006, p = 0.008, HRR = 1.762). The scores of glomerular index and glomerular sclerosis index were higher in GG genotype patients than those in other genotypes (F = 4.570, p = 0.033, F = 4.324, p = 0.038, respectively). The distribution frequency of GG genotype in the progressive group was higher than that of the stable group (χ 2 = 4.370, p = 0.037). No statistical difference was found in tubulo-interstitial index, vascular index and clinical characteristics between the 2 groups. Conclusion: The polymorphism of megsin A23167G is associated with susceptibility and progression of IgA nephropathy in Chinese population. GG genotype is associated with severe histological lesions and progression of the disease. ©2006 Dustri-Verlag Dr. K. Feistle.
Persistent Identifierhttp://hdl.handle.net/10722/162945
ISSN
2015 Impact Factor: 1.065
2015 SCImago Journal Rankings: 0.498
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, YFen_US
dc.contributor.authorHuang, Sen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorYang, Nen_US
dc.contributor.authorHuang, Jen_US
dc.contributor.authorXue, Cen_US
dc.contributor.authorZhang, Men_US
dc.contributor.authorLeung, JCKen_US
dc.contributor.authorLam, MFen_US
dc.contributor.authorLi, Jen_US
dc.date.accessioned2012-09-05T05:25:44Z-
dc.date.available2012-09-05T05:25:44Z-
dc.date.issued2006en_US
dc.identifier.citationClinical Nephrology, 2006, v. 65 n. 3, p. 153-159en_US
dc.identifier.issn0301-0430en_US
dc.identifier.urihttp://hdl.handle.net/10722/162945-
dc.description.abstractAims: To investigate the association of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in Chinese population. Methods: 435 IgA nephropathy patients and their family members were recruited for a family-based association study. Genotypes of megsin A23167G were determined by direct sequencing. The results were analyzed by transmission disequilibrium test (TDT) and haplotype relative risk (HRR). Clinical data and histological scores of renal lesions were compared between patients with different genotypes. According to disease stability, IgA nephropathy patients were divided into progressive group and stable group. The distribution of genotype frequencies were compared between the 2 groups. Results: TDT revealed that megsin 23167G alleles were transmitted more frequently from heterozygous parents to patients than expected (classical TDT: χ 2 = 5.435, p = 0.020, extended TDT: χ 2 = 5.017, p = 0.025). HRR analyses showed significant differences between transmitted and nontransmitted allele frequencies (χ 2 = 7.006, p = 0.008, HRR = 1.762). The scores of glomerular index and glomerular sclerosis index were higher in GG genotype patients than those in other genotypes (F = 4.570, p = 0.033, F = 4.324, p = 0.038, respectively). The distribution frequency of GG genotype in the progressive group was higher than that of the stable group (χ 2 = 4.370, p = 0.037). No statistical difference was found in tubulo-interstitial index, vascular index and clinical characteristics between the 2 groups. Conclusion: The polymorphism of megsin A23167G is associated with susceptibility and progression of IgA nephropathy in Chinese population. GG genotype is associated with severe histological lesions and progression of the disease. ©2006 Dustri-Verlag Dr. K. Feistle.en_US
dc.languageengen_US
dc.publisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.comen_US
dc.relation.ispartofClinical Nephrologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAllelesen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDna - Geneticsen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGlomerulonephritis, Iga - Epidemiology - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshSerpins - Geneticsen_US
dc.titleA family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailLeung, JCK:jckleung@hku.hken_US
dc.identifier.authorityLeung, JCK=rp00448en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16550745-
dc.identifier.scopuseid_2-s2.0-33644778552en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644778552&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume65en_US
dc.identifier.issue3en_US
dc.identifier.spage153en_US
dc.identifier.epage159en_US
dc.identifier.isiWOS:000236237000001-
dc.publisher.placeMünchen-Deisenhofen, Germanyen_US
dc.identifier.scopusauthoridXia, YF=55248957900en_US
dc.identifier.scopusauthoridHuang, S=12766320900en_US
dc.identifier.scopusauthoridLi, X=27168277100en_US
dc.identifier.scopusauthoridYang, N=7202173206en_US
dc.identifier.scopusauthoridHuang, J=23992355800en_US
dc.identifier.scopusauthoridXue, C=12767328700en_US
dc.identifier.scopusauthoridZhang, M=8531407100en_US
dc.identifier.scopusauthoridLeung, JCK=7202180349en_US
dc.identifier.scopusauthoridLam, MF=35300050600en_US
dc.identifier.scopusauthoridLi, J=27171599000en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats