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Article: Helicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients

TitleHelicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients
Authors
Issue Date2006
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.asp
Citation
Scandinavian Journal Of Gastroenterology, 2006, v. 41 n. 3, p. 274-279 How to Cite?
AbstractObjective. Familial aggregation of gastric cancer has been linked to familial clustering of Helicobacter pylori infection. Patterns and risk factors associated with H. pylori infection were investigated in 1st degree relatives of Chinese gastric cancer patients. Material and methods. Gastric cancer relatives were invited for screening endoscopy. H. pylori infection was diagnosed by endoscopic and serological methods. Results. Among the 270 cancer relatives examined, 161 (59.6%) were found to be infected with H. pylori. The prevalence of infection in cancer relatives was significantly higher than age- and gender-matched dyspeptic control (45.5%, p = 0.0006). The mean age of H. pylori-infected relatives was significantly older than that of non-infected relatives (43.9 versus 38.3 years; p < 0.001). The prevalence of H. pylori infection was higher in those with more siblings (p = 0.013, χ 2 test for trend). Moreover, individuals whose siblings had stomach cancer were more likely to have H. pylori infection than those with a parental history of cancer (68.2% versus 51.8%, p = 0.007). In contrast, the youngest sibling had a significantly lower H. pylori infection rate than other siblings (39.2% versus 64.2%, p = 0.001). Using multiple logistic regression, it was found that age >45 years (OR = 1.8; 95% CI, 1.02-3.3) and a history of gastric cancer in siblings (OR = 1.9; 95% CI, 1.06-3.3) were independent risk factors for H. pylori infection, and that the youngest sibling in the family had a reduced risk (OR = 0.45; 95% CI, 0.24-0.84). Conclusions. This study identifies the patterns and risk factors for H. pylori in gastric cancer relatives, which may shed light on the evolving epidemiology of H. pylori infection in Chinese patients. © 2006 Taylor & Francis.
Persistent Identifierhttp://hdl.handle.net/10722/162942
ISSN
2015 Impact Factor: 2.199
2015 SCImago Journal Rankings: 0.891
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WKen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorLam, CCHen_US
dc.contributor.authorChan, KFen_US
dc.contributor.authorChan, WYen_US
dc.contributor.authorAuyeung, ACMen_US
dc.contributor.authorWu, JCYen_US
dc.contributor.authorChing, JYLen_US
dc.contributor.authorLau, JYWen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:25:38Z-
dc.date.available2012-09-05T05:25:38Z-
dc.date.issued2006en_US
dc.identifier.citationScandinavian Journal Of Gastroenterology, 2006, v. 41 n. 3, p. 274-279en_US
dc.identifier.issn0036-5521en_US
dc.identifier.urihttp://hdl.handle.net/10722/162942-
dc.description.abstractObjective. Familial aggregation of gastric cancer has been linked to familial clustering of Helicobacter pylori infection. Patterns and risk factors associated with H. pylori infection were investigated in 1st degree relatives of Chinese gastric cancer patients. Material and methods. Gastric cancer relatives were invited for screening endoscopy. H. pylori infection was diagnosed by endoscopic and serological methods. Results. Among the 270 cancer relatives examined, 161 (59.6%) were found to be infected with H. pylori. The prevalence of infection in cancer relatives was significantly higher than age- and gender-matched dyspeptic control (45.5%, p = 0.0006). The mean age of H. pylori-infected relatives was significantly older than that of non-infected relatives (43.9 versus 38.3 years; p < 0.001). The prevalence of H. pylori infection was higher in those with more siblings (p = 0.013, χ 2 test for trend). Moreover, individuals whose siblings had stomach cancer were more likely to have H. pylori infection than those with a parental history of cancer (68.2% versus 51.8%, p = 0.007). In contrast, the youngest sibling had a significantly lower H. pylori infection rate than other siblings (39.2% versus 64.2%, p = 0.001). Using multiple logistic regression, it was found that age >45 years (OR = 1.8; 95% CI, 1.02-3.3) and a history of gastric cancer in siblings (OR = 1.9; 95% CI, 1.06-3.3) were independent risk factors for H. pylori infection, and that the youngest sibling in the family had a reduced risk (OR = 0.45; 95% CI, 0.24-0.84). Conclusions. This study identifies the patterns and risk factors for H. pylori in gastric cancer relatives, which may shed light on the evolving epidemiology of H. pylori infection in Chinese patients. © 2006 Taylor & Francis.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.aspen_US
dc.relation.ispartofScandinavian Journal of Gastroenterologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntibodies, Bacterial - Analysisen_US
dc.subject.meshBiopsyen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshEndoscopy, Gastrointestinalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Complications - Epidemiology - Transmissionen_US
dc.subject.meshHelicobacter Pylori - Immunology - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshInfectious Disease Transmission, Verticalen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPedigreeen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPrognosisen_US
dc.subject.meshStomach Neoplasms - Complications - Genetics - Pathologyen_US
dc.titleHelicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patientsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/00365520510024269en_US
dc.identifier.pmid16497613en_US
dc.identifier.scopuseid_2-s2.0-33644592804en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644592804&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue3en_US
dc.identifier.spage274en_US
dc.identifier.epage279en_US
dc.identifier.isiWOS:000235500400005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridLam, CCH=14321941100en_US
dc.identifier.scopusauthoridChan, KF=14324453900en_US
dc.identifier.scopusauthoridChan, WY=37041920900en_US
dc.identifier.scopusauthoridAuyeung, ACM=12760347200en_US
dc.identifier.scopusauthoridWu, JCY=7409260329en_US
dc.identifier.scopusauthoridChing, JYL=7005086238en_US
dc.identifier.scopusauthoridLau, JYW=13907867100en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.citeulike519980-

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